Daclizumab (anti-IL2RA) - Primary antibody, specific to IL2RA, >95%, Human IgG1, INHIBITOR of Interleukin-2 receptor inhibitor, INHIBITOR of Interleukin-2 receptor inhibitor

CAS: 152923-56-3 Cat. No.: Ab170892

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Human, Mouse, Rat, Rhesus monkey

Isotype

Human IgG1

Conjugation

Unconjugated

Overview

Daclizumab (anti-IL2RA) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab (anti-IL2RA) reversibly binds to CD25and prevents the interaction of IL-2 with the IL-2R-HA. Daclizumab (anti-IL2RA) can be used for multiple sclerosis research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Daclizumab (anti-IL2RA) - Primary antibody, specific to IL2RA, >95%, Human IgG1, INHIBITOR of Interleukin-2 receptor inhibitor

Synonyms

Interleukin 2 receptor alpha chain antibody | CD25 antibody | CD25 antigen antibody | IDDM10 antibody | IL 2 receptor alpha subunit antibody | IL-2 receptor subunit alpha antibody | IL-2-RA antibody | IL-2R subunit alpha antibody | IL2 RA antibody | IL2 R

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

IL2RA

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

INHIBITOR

Mechanism of action

INHIBITOR of Interleukin-2 receptor inhibitor

Isotype

Human IgG1

Light Chain Type

kappa

SDS-PAGE

27.1 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 178.6 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Concentration

See COA

CAS

152923-56-3

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Flow Cytometry: Daclizumab (anti-IL2RA) (Ab170892)

Daclizumab (anti-IL2RA) (Ab170892) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood mononuclear lymphocytes labelling IL2RA (red) with Daclizumab (anti-IL2RA) (Ab170892). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Daclizumab (anti-IL2RA) (Ab170892)

Daclizumab (anti-IL2RA) (Ab170892) - SEC
The purity of Daclizumab (anti-IL2RA) (Ab170892) is more than 95% verified by HPLC.

ELISA: Daclizumab (anti-IL2RA) (Ab170892)

Daclizumab (anti-IL2RA) (Ab170892) - ELISA
Immobilized TARGET at 2 μg/mL can bind Daclizumab (anti-IL2RA) (Ab170892) with the EC₅₀ of 31.47 ng/mL.

Associated Targets(Human)

IL2RA Tclin Interleukin-2 receptor subunit alpha (0 Activities)

Discover Target: IL2RA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL2RA Tclin Interleukin-2 receptor alpha chain (2 Activities)

Discover Target: IL2RA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action