CD28

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  1. MDK 24720 (CTLA-4 inhibitor)
    CAS: 635324-72-0 Summenformel: C21H13F4N5O Molekulargewicht: 427.35
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: M412249
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    Technische Identifikatoren
    IUPAC-Bezeichnung
    4-(4-fluorophenyl)-10-methyl-7-[3-(trifluoromethyl)phenyl]-3,4,8,10,11-pentazatricyclo[7.3.0.02,6]dodeca-1,6,8,11-tetraen-5-one
    SMILES
    CN1C2=NC(=C3C(=C2C=N1)NN(C3=O)C4=CC=C(C=C4)F)C5=CC(=CC=C5)C(F)(F)F
    InChIKey
    WQKVVTLTCHDAST-UHFFFAOYSA-N
    InChI
    1S/C21H13F4N5O/c1-29-19-15(10-26-29)18-16(20(31)30(28-18)14-7-5-13(22)6-8-14)17(27-19)11-3-2-4-12(9-11)21(23,24)25/h2-10,28H,1H3
    Synonyme
    2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one | B7/...
  2. Tiragolumab (anti-TIGIT), INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor
    CAS: 1918185-84-8
    Flüssigkeit Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: Ab169250
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    Associated targets
    TIGIT
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Reaktive Spezies
    Cynomolgus-Affe, Kaninchen, Mensch
    Isotyp
    Human IgG1
    Wirtsspezies
    Mensch
    Konjugation
    Unconjugated
    Synonyme
    RG6058 | MTIG7192A | T cell immunoreceptor with Ig and ITIM domains | TIGIT | VSIG9 | VSTM3 | WUCAM | DKFZp667A205 an...
  3. Prezalumab (anti-B7-H2)
    CAS: 1523164-68-2
    Flüssigkeit Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: Ab170952
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    Technische Identifikatoren
    Associated targets
    ICOSLG
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Reaktive Spezies
    Cynomolgus-Affe, Maus, Mensch
    Isotyp
    Human IgG2SA
    Wirtsspezies
    Mensch
    Konjugation
    Unconjugated
    Synonyme
    B7 H2 antibody | B7 homolog 2 antibody | B7 homologue 2 antibody | B7 like protein Gl50 antibody | B7 related protein...
  4. Galiximab (anti-CD80), INHIBITOR of T-lymphocyte activation antigen CD80 inhibitor
    CAS: 357613-77-5
    Flüssigkeit Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: Ab177850
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    Preise & Packungsgrößen
    Technische Identifikatoren
    Associated targets
    CD80
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Reaktive Spezies
    Cynomolgus-Affe, Mensch
    Isotyp
    Human IgG1
    Wirtsspezies
    Mensch
    Konjugation
    Unconjugated
    Synonyme
    Activation B7-1 antigen | B7 | BB1 | CTLA-4 counter-receptor B7.1
  5. CD80-IN-3
    CAS: 486449-65-4 PubChem CID: 644103 Summenformel: C17H10FN3O3 Molekulargewicht: 323.28
    Feststoff Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Auf Bestellung · 8–12 Wochen Artikel #: C651374
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    IUPAC-Bezeichnung
    4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]quinolin-2-yl)benzoic acid
    SMILES
    C1=CC2=C3C(=CN=C2C(=C1)F)C(=O)N(N3)C4=CC=C(C=C4)C(=O)O
    InChIKey
    NLGJRBLPUVEYKC-UHFFFAOYSA-N
    InChI
    1S/C17H10FN3O3/c18-13-3-1-2-11-14-12(8-19-15(11)13)16(22)21(20-14)10-6-4-9(5-7-10)17(23)24/h1-8,20H,(H,23,24)
    Synonyme
    LBEWFVRAHKOLOU-UHFFFAOYSA-N | CD80-IN-3 | benzoic acid, 4-(6-fluoro-3,5-dihydro-3-oxo-2H-pyrazolo[4,3-c]quinolin-2-yl...
  6. Theralizumab (anti-CD28)
    CAS: 906068-56-2
    Flüssigkeit Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: Ab190136
    Produkt anzeigen
    Preise & Packungsgrößen
    Technische Identifikatoren
    Associated targets
    CD28
    Short Overview
    Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Reaktive Spezies
    Mensch
    Isotyp
    Human IgG4
    Wirtsspezies
    Mensch
    Konjugation
    Unconjugated
    SMILES
    [Theralizumab]
    Synonyme
    CD 28 antibody | CD28 antibody | CD28 antigen antibody | CD28 molecule antibody | CD28_HUMAN antibody | MGC138290 ant...
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Häufig gestellte Fragen

How is the CD28 listing put together?
It draws on reported CD28 annotations within Immunology/Inflammation and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a CD28 modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the CD28 entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for CD28 compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For CD28 work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the CD28 compound I need is not listed?
Search by CAS number or SMILES first, since analogs of CD28 compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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