GRADE & PURITYCarrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Validated?Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated.ExactAb™?ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications.Azide Free?Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory.PBS Only?PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers.≥95%(SDS-PAGE)See COA
Carrier Free,ExactAb™,Azide Free,Validated,PBS Only,≥95%(SDS-PAGE),See COA Azide Free,Carrier Free,ExactAb™,PBS Only,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at 2-8°C,Do not freeze Ships Wet ice,Do not freeze Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Rat anti Mouse Transferrin Receptor/CD71 Antibody, Monoclonal (R17 217.1.3), could be used for Flow, in vivo depletion of CD71+ cells and so on. Application: in vivo depletion of CD71+ cells: Use at an assay dependent concentration. Flow: Use at an assay dependent concentration. Protein Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Specifications
Product Name
Transferrin Receptor/CD71 Rat mAb - Primary antibody, specific to Transferrin Receptor/CD71, Rat IgG2a
30.1kDa (Light Chain) & 50.9 kDa (Heavy Chain), under reducing conditions; 219.2 kDa, under non-reducing conditions.
Purification Method
Protein G purified
Concentration
See COA
Storage and Shipping
Shape
Liquid
Storage
Store at 2-8°C,Do not freeze
Shipped In
Wet ice,Do not freeze
Stability And Storage
Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.
Images
Transferrin Receptor/CD71 Rat mAb (Ab132257) - Flow Cytometry Two-color flow cytometric analysis of Transferrin Receptor/CD71 expression on mouse bone marrow cells. C57BL/6 mouse bone marrow cells were stained with CD45R Rat mAb (AF647) (Ab191663) and either Rat IgG Isotype Control Antibody (Biotin) (Ab180310; Left panel) or Transferrin Receptor/CD71 Rat mAb (Ab132257; Right panel) at 0.5 μg/mL. Two-color flow cytometric dot plots showing the correlated expression of CD45R versus Transferrin Receptor/CD71 (or Isotype control staining) were derived from gated events with the forward and side light-scatter characteristics of viable mononuclear cells.
Application
Application
Dilution info
Flow Cytometry
Use at an assay dependent concentration.
in vivo depletion of CD71+ cells
Use at an assay dependent concentration.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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