Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 37 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Fluoxetine is a 5-hydroxytryptamine reuptake inhibitor.
| Canonical Smiles | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F |
|---|---|
| IUPAC Name | N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine |
| InChIKey | RTHCYVBBDHJXIQ-UHFFFAOYSA-N |
| INCHI | 1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 |
| Isomeric SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F |
| Alternate CAS | 56296-78-7 |
| UN Number | 3265 |
| Packing Group | I |
| Molecular Weight | 309.33 |
| Reaxy-Rn | 3991406 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3991406&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Trifluoromethylbenzenes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Trifluoromethylbenzenes |
| Alternative Parents | Phenoxy compounds Phenol ethers Aralkylamines Alkyl aryl ethers Dialkylamines Organopnictogen compounds Organofluorides Hydrocarbon derivatives Alkyl fluorides |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Trifluoromethylbenzene - Phenoxy compound - Phenol ether - Alkyl aryl ether - Aralkylamine - Secondary aliphatic amine - Ether - Secondary amine - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Organic nitrogen compound - Amine - Alkyl halide - Organopnictogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as trifluoromethylbenzenes. These are organofluorine compounds that contain a benzene ring substituted with one or more trifluoromethyl groups. |
| External Descriptors | aromatic ether - secondary amino compound - (trifluoromethyl)benzenes |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jan 09, 2026 | F189157 | |
| Certificate of Analysis | Jan 09, 2026 | F189157 | |
| Certificate of Analysis | Jul 29, 2025 | F189157 | |
| Certificate of Analysis | Jul 29, 2025 | F189157 | |
| Certificate of Analysis | May 14, 2025 | F189157 | |
| Certificate of Analysis | May 14, 2025 | F189157 | |
| Certificate of Analysis | May 14, 2025 | F189157 | |
| Certificate of Analysis | May 14, 2025 | F189157 | |
| Certificate of Analysis | May 14, 2025 | F189157 | |
| Certificate of Analysis | Jul 13, 2024 | F189157 | |
| Certificate of Analysis | Jul 13, 2024 | F189157 | |
| Certificate of Analysis | Mar 12, 2024 | F189157 | |
| Certificate of Analysis | Mar 12, 2024 | F189157 | |
| Certificate of Analysis | Feb 27, 2023 | F189157 | |
| Certificate of Analysis | Feb 06, 2023 | F189157 | |
| Certificate of Analysis | Feb 03, 2023 | F189157 | |
| Certificate of Analysis | Mar 15, 2022 | F189157 | |
| Certificate of Analysis | Jun 18, 2021 | F189157 | |
| Certificate of Analysis | Jun 18, 2021 | F189157 |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
|---|---|
| Molecular Weight | 309.330 g/mol |
| XLogP3 | 4.000 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 6 |
| Exact Mass | 309.134 Da |
| Monoisotopic Mass | 309.134 Da |
| Topological Polar Surface Area | 21.300 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 308.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Jiao-Zhao Yan, Guang-Xiang Li, Si-Rui Sun, Lin-Yu Cui, Yong-Yu Yin, Yun-Feng Li. (2023) A rate-limiting step in antidepressants onset: Excitation of glutamatergic pyramidal neurons in medial prefrontal cortex of rodents. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, [PMID:38065287] [10.1016/j.pnpbp.2023.110911] |
| 2. Yiyang Du, Tingxu Yan, Bo Wu, Bosai He, Ying Jia. (2023) Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37739105] [10.1016/j.jep.2023.117190] |
| 3. Yu Hui, Shao Shumin, Xu Junnan, Guo Haibiao, Zhong Zhangfeng, Xu Jiangping. (2022) Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice. Chinese Medicine, 17 (1): (1-20). [PMID:35668445] [10.1186/s13020-022-00609-4] |
| 4. Qianqian Shang, Huajing Liu, Hang Mei, Chuixiu Huang, Xiantao Shen. (2022) Multi-extraction system with identical supported semi-liquid membrane: Enhanced stability for coextraction of acidic and basic drugs. TALANTA, [PMID:35462249] [10.1016/j.talanta.2022.123485] |
| 5. Tiantian Wang, Ruihe Zheng, Song Sun. (2022) Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:35158201] [10.1016/j.bbrc.2022.02.015] |
| 6. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang. (2021) Successive liquid-phase microextraction of acidic and basic analytes. ANALYTICA CHIMICA ACTA, [PMID:35057942] [10.1016/j.aca.2021.339335] |
| 7. Yanqiu Chen, Mei Wan, Yi Zhong, Tingfang Gao, Yuehan Zhang, Fen Yan, Da Huang, Yuanzi Wu, Zuquan Weng. (2021) Partially Hydrolyzed Guar Gum Modulates Gut Microbiota, Regulates the Levels of Neurotransmitters, and Prevents CUMS-Induced Depressive-Like Behavior in Mice. MOLECULAR NUTRITION & FOOD RESEARCH, 65 (16): (2100146). [PMID:34125489] [10.1002/mnfr.202100146] |
| 8. Yun Wang, Ce Gao, Tianyu Gao, Lu Zhao, Shiguang Zhu, Lin Guo. (2021) Plasma exosomes from depression ameliorate inflammation-induced depressive-like behaviors via sigma-1 receptor delivery. BRAIN BEHAVIOR AND IMMUNITY, [PMID:33607235] [10.1016/j.bbi.2021.02.004] |
| 9. Li Fan, Ying Peng, Jingwen Wang, Ping Ma, Lijuan Zhao, Xiaobo Li. (2021) Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota. PHYTOMEDICINE, [PMID:33636477] [10.1016/j.phymed.2021.153471] |
| 10. Xin Shan, Jing Chen, Shilin Dai, Jie Wang, Zhiheng Huang, Zhiyang Lv, Qian Wang, Qinan Wu. (2020) Cyanidin-related antidepressant-like efficacy requires PI3K/AKT/FoxG1/FGF-2 pathway modulated enhancement of neuronal differentiation and dendritic maturation. PHYTOMEDICINE, [PMID:32593103] [10.1016/j.phymed.2020.153269] |
| 11. Lan Zhang, Yue Yang, Lei Di, Jun-long Li, Ning Li. (2020) Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice. PHARMACEUTICAL BIOLOGY, [PMID:32476554] [10.1080/13880209.2020.1765812] |
| 12. Yiqun Chen, Yang Tong, Yingwen Xue, Zizheng Liu, Min Tang, Li-Zhi Huang, Senlin Shao, Zheng Fang. (2019) Degradation of the β-blocker propranolol by sulfite activation using FeS. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2019.123884] |
| 13. Hui Wang, Ling Xiao, Huiling Wang, Gaohua Wang. (2019) Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model. PHYSIOLOGY & BEHAVIOR, [PMID:31770536] [10.1016/j.physbeh.2019.112749] |
| 14. Li Yang, Peng Ying, Ma Ping, Yang Hanlin, Xiong Haiyan, Wang Mengyue, Peng Chongsheng, Tu Pengfei, Li Xiaobo. (2018) Antidepressant-Like Effects of Cistanche tubulosa Extract on Chronic Unpredictable Stress Rats Through Restoration of Gut Microbiota Homeostasis. Frontiers in Pharmacology, [PMID:30186183] [10.3389/fphar.2018.00967] |
| 15. Hongxia Zhao, Lingge Huang, Jian Liu, Min Feng, Yeqian Liu, Hong Li, Shan Gong, Chunming Chen, Shuiqing Zeng, Weiqiong Ren. (2025) A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression. Frontiers in Cellular Neuroscience, [PMID:40230380] [10.3389/fncel.2025.1553309] |
| 16. Ning Jiang, Caihong Yao, Yiwen Zhang, Yuzhen Chen, Fang Chen, Yanqin Luo, Muhammad Iqbal Choudhary, Ruile Pan, Xinmin Liu. (2024) Antidepressant effects of Parishin C in chronic social defeat stress-induced depressive mice. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:38331122] [10.1016/j.jep.2024.117891] |
| 17. Ya Zhu, Lan Li, Shaokui Yi, Rui Hu, Jianjun Wu, Jinqian Xu, Junguang Xu, Qinnan Zhu, Shijia Cen, Yuxuan Yuan, Da Sun, Waqas Ahmad, Huilan Zhang, Xuan Cao, Jingjuan Ju. (2024) Deep learning-assisted detection of psychoactive water pollutants using behavioral profiling of zebrafish embryos. JOURNAL OF HAZARDOUS MATERIALS, [PMID:39486333] [10.1016/j.jhazmat.2024.136358] |
| 18. Fengjiao Liu, Yaxin Jia, Liwei Zhao, Li-na Xiao, Xizhen Cheng, Yingying Xiao, Ying Zhang, Yuling Zhang, Huimin Yu, Qiao-en Deng, Yuanyuan Zhang, Yimeng Feng, junfang Wang, Yonggang Gao, Xuan Zhang, Yunyun Geng. (2024) Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:39426465] [10.1016/j.ejphar.2024.177063] |
| 19. Wenyu Sun, Huiyun Qiu, Susu Lin, Shengqiang Tong. (2024) Impact of the degree of substitution on the enantioseparation of anionic β-cyclodextrin in liquid‒liquid extraction and countercurrent chromatography: Insights from molecular docking simulations. JOURNAL OF CHROMATOGRAPHY A, [PMID:39146865] [10.1016/j.chroma.2024.465255] |
| 20. Lu Yang, Zijin Lin, Ruijing Mu, Wenhan Wu, Hao Zhi, Xiaodong Liu, Hanyu Yang, Li Liu. (2024) Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion. eLife, [PMID:39475379] [10.7554/eLife.96161] |
| 21. Peng Wang, Hui Ouyang, Guofang Bi, Fengting Liang, Shuang Hu, Chenhua Wu, Xiaowen Jiang, Wenhong Zhou, Dan Li, Shuaishuai Zhang, Xiao Yang, Mingliang Zhao, Jian-Hong Fang, Haitao Wang, Wei Jia, Zheng-jiang Zhu, Huichang Bi. (2024) Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor. PHYTOMEDICINE, [PMID:39809031] [10.1016/j.phymed.2024.156340] |
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