PROTAC CDK2/9 Degrader-1 - ≥99% , CAS No.2408641-24-5

CAS: 2408641-24-5 Cat. No.: P646785 Fórmula: C₄₀H₄₁N₁₃O₇ Peso molecular: 815.84

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Descripción general

PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 ( DC 50 =62 nM) and CDK9 ( DC 50 =33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC 50 =0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand

In Vitro

PROTAC CDK2/9 Degrader-1 (0.25-3 μM; 48 hours) induces cell cycle blockage at the G2/M phase. ?\nPROTAC CDK2/9 Degrader-1 (500 nM; 2-24 hours) down-regulates the Mcl-1 protein level in PC-3 cells. ?\nPROTAC CDK2/9 Degrader-1 effectively degrades CDK2/9 in cell lines MCF-7, HCT-116 and 22Rv1, which all have high CDK2/9 expression. ?\nPROTAC CDK2/9 Degrader-1 inhibits both CDK2 and CDK9, with IC 50 as 7.42 nM and 14.50 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle AnalysisCell Line: PC-3 cells Concentration: 500 nM Incubation Time: 2, 4, 8, 16, 24 hours Result: Down-regulated the Mcl-1 protein level in PC-3 cells. Western Blot AnalysisCell Line: PC-3 cells Concentration: 0.25, 1, 3 μM Incubation Time: 48 hours Result: Induced cell cycle blockage at the G2/M phase.

Form:Solid

IC50& Target:CDK2 62 nM (DC 50 ) CDK9 33 nM (DC 50 ) Cereblon

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 ( DC 50 =62 nM) and CDK9 ( DC 50 =33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC 50 =0.12 µM) by effectively blocking the cell cycle in S an

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

Peso molecular

815.84

Propiedades químicas y físicas

• Solubilidad: DMSO : 55 mg/mL (67.42 mM; Need ultrasonic)

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2408641-24-5, the molecular formula is C40H41N13O7, and the molecular weight is 815.84 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.