PROTAC

Comprehensive guideline on Bis-PEG7-acid: structure, solubility, storage, bioconjugation protocols, and PROTAC linker applications for research scientists.

Step-by-step guidelines for storing, handling, and using Acid-PEG5-t-butyl ester (A596986) as a PEG linker in bioconjugation and PROTAC research.

Explore Amino-PEG36-CONH-PEG36-acid (A596370), a long-chain bifunctional PEG linker for bioconjugation, PROTAC, and drug delivery research.

Handling, storage, and research-use guidelines for 3-(4-Piperazin-1-ylanilino)piperidine-2,6-dione dihydrochloride (SKU P1529534) from Aladdin Scientific.

KRAS G12D is an important driver mutation in solid tumors such as pancreatic, colorectal, and lung cancers. The emergence of molecules such as MRTX1133 has demonstrated that KRAS G12D can be directly targeted pharmacologically, whereas targeted protein degradation technologies such as PROTACs ...

Classical PROTACs rely on E3 ubiquitin ligases and the proteasome to eliminate intracellular target proteins, but they are difficult to apply to extracellular proteins, large-scale cellular components, and bacterial proteins. LYTAC, ATTEC, AUTAC, and BacPROTAC respectively utilize ...

RAS mutations drive many tumors, including pancreatic cancer, colorectal cancer, and lung cancer. However, RAS was long considered difficult to drug because of its shallow structural pockets and tight GTP binding. The emergence of RAS(ON) inhibitors, molecular glues, and PROTACs has shifted RAS ...

PROTACs (PROteolysis-TArgeting Chimeras) are heterobifunctional small molecules that induce targeted protein degradation. Each PROTAC molecule contains two distinct ligands: one is a target protein ligand that binds specifically to the intracellular protein of interest (POI), and the other is a ...

The anticancer drug Lenalidomide was once one of the world's top-selling small molecule drugs and orphan drugs, with sales of up to 9.978 billion US dollars in 2022, and its development company Celgene made huge profits.