(9-Fluorenylmethyl) chloroformate - for synthesis , CAS No.28920-43-6

CAS: 28920-43-6 Cat. No.: F432547 Molecular Weight: 258.7 Beilstein Registry Number: 2279177 EC Number: 249-313-6

GRADE & PURITY for Synthesis

Synonyms

9-fluorenylmethylchloroformate | 9-fluorenylmethyl-chloroformate | AC-24425 | BP-21051 | AKOS009157869 | C93459 | Fmoc chloride, BioReagent, >=99.0% (HPLC) | EN300-37269 | Fluoren-9-ylmethyl chloroformate | FmocCl | Fmoc-Cl | FMOC-Cl?Chloroformic acid 9-f

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Specifications

Synonyms

9-fluorenylmethylchloroformate | 9-fluorenylmethyl-chloroformate | AC-24425 | BP-21051 | AKOS009157869 | C93459 | Fmoc chloride, BioReagent, >=99.0% (HPLC) | EN300-37269 | Fluoren-9-ylmethyl chloroformate | FmocCl | Fmoc-Cl | FMOC-Cl?Chloroformic acid 9-f

Specifications & Purity

for synthesis

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

for Synthesis

Names and Identifiers

• Pubchem Sid: 504753528
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504753528
• Canonical Smiles: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl
• IUPAC Name: 9H-fluoren-9-ylmethyl carbonochloridate
• InChIKey: IRXSLJNXXZKURP-UHFFFAOYSA-N
• INCHI: 1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
• Isomeric SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl
• WGK Germany: 3
• RTECS: LQ6250000
• UN Number: 3261
• Molecular Weight: 258.7
• Beilstein: 2279177
• Reaxy-Rn: 2279177
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2279177&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Organic carbonic acids and derivatives Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Fluorene - Carbonic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organochloride - Organohalogen compound - Carbonyl group - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Moisture sensitive；Heat sensitive
• Melt Point(°C): 61.0 - 65.0 °C
• Molecular Weight: 258.700 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 258.045 Da
• Monoisotopic Mass: 258.045 Da
• Topological Polar Surface Area: 26.300 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 296.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Hang Xu, Mengfei Zheng, Chenguang Yang, Kun Wang, Zheng Lv, Zhilin Liu, Zhaohui Tang, Xuesi Chen.  (2023)  Azo-based hypoxic-activated 6-diazo-5-oxo-L-norleucine (DON) prodrug combined with vascular disrupting agent nanoparticles for tumor-selective glutamine metabolism blockade.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.148281]

2. Biao Yan, Yumiao Sun, Kaiyu Fu, Yindan Zhang, Lei Lei, Jun Men, Yongyong Guo, Shengmin Wu, Jian Han, Bingsheng Zhou.  (2023)  Effects of glyphosate exposure on gut–liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus).  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:37544446] [10.1016/j.scitotenv.2023.166062]

3. Qian Hai-Long, Liu Fang, Liu Xue, Yang Cheng, Yan Xiu-Ping.  (2021)  Chiral covalent organic framework-monolith as stationary phase for high-performance liquid chromatographic enantioseparation of selected amino acids.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  414  (18): (5255-5262).  [PMID:34331090] [10.1007/s00216-021-03574-3]

4. Chang Wang, Yike Wu, Sheng Liu, Liang Zhang, Bi-Feng Liu, Xin Liu.  (2020)  Fmoc N-hydroxysuccinimide ester: A facile and multifunctional role in N-glycan analysis.  ANALYTICA CHIMICA ACTA,      [PMID:32928480] [10.1016/j.aca.2020.07.044]

5. Can Wu, Jing Liu, Ziran Zhai, Liqiang Yang, Xuan Tang, Lingzhi Zhao, Keming Xu, Wenying Zhong.  (2020)  Double-crosslinked nanocomposite hydrogels for temporal control of drug dosing in combination therapy.  Acta Biomaterialia,      [PMID:32084599] [10.1016/j.actbio.2020.02.021]

6. Luyao Zhang, Li Chen, Zhiyuan Meng, Ming Jia, Ruisheng Li, Sen Yan, Sinuo Tian, Zhiqiang Zhou, Jinling Diao.  (2019)  Effects of L-Glufosinate-ammonium and temperature on reproduction controlled by neuroendocrine system in lizard (Eremias argus).  ENVIRONMENTAL POLLUTION,      [PMID:31753638] [10.1016/j.envpol.2019.113564]

7. Wu Hao, Guo Ye, Chen Lei, Chen Guiguang, Liang Zhiqun.  (2019)  A Novel Strategy to Regulate 1-Deoxynojirimycin Production Based on Its Biosynthetic Pathway in Streptomyces lavendulae.  Frontiers in Microbiology,      [PMID:31507573] [10.3389/fmicb.2019.01968]

8. Luyao Zhang, Li Chen, Zhiyuan Meng, Wenjun Zhang, Xin Xu, Zikang Wang, Yinan Qin, Yue Deng, Rui Liu, Zhiqiang Zhou, Jinling Diao.  (2019)  Bioaccumulation, behavior changes and physiological disruptions with gender-dependent in lizards (Eremias argus) after exposure to glufosinate-ammonium and l-glufosinate-ammonium.  CHEMOSPHERE,      [PMID:30965253] [10.1016/j.chemosphere.2019.04.007]

9. Luyao Zhang, Jinling Diao, Li Chen, Zikang Wang, Wenjun Zhang, Yao Li, Zhongnan Tian, Zhiqiang Zhou.  (2018)  Hepatotoxicity and reproductive disruption in male lizards (Eremias argus) exposed to glufosinate-ammonium contaminated soil.  ENVIRONMENTAL POLLUTION,      [PMID:30543945] [10.1016/j.envpol.2018.12.004]

10. Tang Lirong, Lin Fengcai, Li Tao, Cai Zhenghan, Hong Biyun, Huang Biao.  (2018)  Design and synthesis of functionalized cellulose nanocrystals-based drug conjugates for colon-targeted drug delivery.  CELLULOSE,  25  (8): (4525-4536).  [PMID:] [10.1007/s10570-018-1904-2]

11. Shengfeng Huang, Ning Gan, Tianhua Li, You Zhou, Yuting Cao, Youren Dong.  (2017)  Electrochemical aptasensor for multi-antibiotics detection based on endonuclease and exonuclease assisted dual recycling amplification strategy.  TALANTA,      [PMID:29310232] [10.1016/j.talanta.2017.10.016]

12. Bo Xing, Honglin Chen, Xiaoming Zhang.  (2017)  Efficient degradation of organic phosphorus in glyphosate wastewater by catalytic wet oxidation using modified activated carbon as a catalyst.  ENVIRONMENTAL TECHNOLOGY,      [PMID:28332926] [10.1080/09593330.2017.1310935]

13. Lirong Tang, Tao Li, Senyang Zhuang, Qilin Lu, Pengfei Li, Biao Huang.  (2016)  Synthesis of pH-Sensitive Fluorescein Grafted Cellulose Nanocrystals with an Amino Acid Spacer.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.6b01124]

14. Zhang Hui, Zhang Ge, Xu Jing-kun, Wen Yang-ping, Ding Wan-chuan, Zhang Jie, Ming Shou-li, Zhen Shi-jie.  (2015)  Electrosynthesis, characterization and optical sensing application of amino acid functionalized polyfluorene.  CHINESE JOURNAL OF POLYMER SCIENCE,  34  (2): (229-241).  [PMID:] [10.1007/s10118-016-1742-3]

15. Kaili Liang, Li Yang, Jiawei Kang, Bo Liu, Ding Zhang, Liyan Wang, Wei Wang, Qing Wang.  (2024)  Improving Treatment for Parkinson's Disease: Harnessing Photothermal and Phagocytosis-Driven Delivery of Levodopa Nanocarriers Across the Blood-Brain Barrier.  Asian Journal of Pharmaceutical Sciences,      [PMID:39640059] [10.1016/j.ajps.2024.100963]

16. Ruili Ma, Weiguo Wu, Yikang Shu, Ran Gao, Ziyu Wang, Daoquan Tang, Yan Du, Shuai Ji.  (2025)  Simultaneous extraction and in situ separation of flavonoids and alkaloids from mulberry leaves using a pH-responsive deep eutectic solvent/water system.  FOOD CHEMISTRY,      [PMID:39884234] [10.1016/j.foodchem.2025.143008]

17. Danyi Chen, Rongrong Zhao, Honglin Liu, Hailin Tian, Yiqun Tian, Di Huang, David Johnson, Yingping Huang.  (2025)  Selective photo-Fenton degradation of glyphosate using Schiff base metal complexes: Insights into metal-mediated pathways.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2025.144837]

18. Na Guo, Yi-Wei Jiang, Ping Kou, Zhi-Ming Liu, Thomas Efferth, Yan-Yan Li, Yu-Jie Fu.  (2019)  Application of integrative cloud point extraction and concentration for the analysis of polyphenols and alkaloids in mulberry leaves.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:30771646] [10.1016/j.jpba.2019.02.002]

19. Shuai Yang, Lin Zhang, Yibing Sun, Zhichao Yang, Hongchao Li.  (2025)  Nonradical degradation of phosphonates to orthophosphate via surface-activated peroxides on carbon nanotubes.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.133242]

20. Chaonan Huang, Li Wang, Huiqing Zhang, Weiqiang Tan, Lingxia Wu, ShaSha Wang, Jiping Ma.  (2026)  Cold-Induced Phase Separation Coupled With High-Performance Liquid Chromatography-Fluorescence Detection for Determination of Glyphosate, Aminomethylphosphonic Acid, and Glufosinate in Environmental Water.  JOURNAL OF SEPARATION SCIENCE,  49  (3): (e70399).  [PMID:] [10.1002/jssc.70399]