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· · COA & SDS available for every product · Same-day shipping on in-stock items FRAX 597 - Moligand™, ≥98%(HPLC) , Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of p21 (RAC1) activated kinase 2;Inhibitor of p21 (RAC1) activated kinase 3;Inhibitor of p21 (RAC1) activated kinase 4, CAS No.1286739-19-2, Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of p21 (RAC1) activated kinase 2;Inhibitor of p21 (RAC1) activated kinase 3;Inhibitor of p21 (RAC1) activated kinase 4
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC) Synonyms
p21-Activated Kinase Inhibitor III | 6-(2-Chloro-4-(thiazol-5-yl)phenyl)-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one | PAK Inhibitor III | FRAX-597 | 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiper
Storage
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
p21-Activated Kinase Inhibitor III | 6-(2-Chloro-4-(thiazol-5-yl)phenyl)-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2, 3-d]pyrimidin-7(8H)-one | PAK Inhibitor III | FRAX-597 | 6-[2-chloro-4-(1, 3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiper
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
Cell permeable: yes
Primary Target
p21 activated kinase
Target IC50: 7.7, 12.8, and 19.3 nM for PAK1, 2, and 3, respectively
Storage
Protected from light, Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of p21 (RAC1) activated kinase 2;Inhibitor of p21 (RAC1) activated kinase 3;Inhibitor of p21 (RAC1) activated kinase 4
Names and Identifiers Canonical Smiles CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C IUPAC Name 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one InChIKey DHUJCQOUWQMVCG-UHFFFAOYSA-N INCHI 1S/C29H28ClN7OS/c1-3-37-27-20(14-24(28(37)38)23-9-4-19(15-25(23)30)26-17-31-18-39-26)16-32-29(34-27)33-21-5-7-22(8-6-21)36-12-10-35(2)11-13-36/h4-9,14-18H,3,10-13H2,1-2H3,(H,32,33,34) Isomeric SMILES CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C Molecular Weight 558.1 Reaxy-Rn 23567473 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23567473&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Diazinanes Subclass Piperazines Intermediate Tree Nodes Not available Direct Parent Phenylpiperazines Alternative Parents N-arylpiperazines Phenylpyridines Pyrido[2,3-d]pyrimidines Aniline and substituted anilines Dialkylarylamines Aminopyrimidines and derivatives Chlorobenzenes Pyridinones N-methylpiperazines Aryl chlorides Heteroaromatic compounds Thiazoles Lactams Trialkylamines Azacyclic compounds Hydrocarbon derivatives Organic oxides Organochlorides Organooxygen compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents Phenylpiperazine - 3-phenylpyridine - N-arylpiperazine - Pyrido[2,3-d]pyrimidine - Pyridopyrimidine - Aniline or substituted anilines - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Aminopyrimidine - Chlorobenzene - Halobenzene - Pyridinone - N-alkylpiperazine - N-methylpiperazine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyridine - Benzenoid - Pyrimidine - Thiazole - Heteroaromatic compound - Azole - Tertiary amine - Tertiary aliphatic amine - Lactam - Azacycle - Amine - Organohalogen compound - Organic oxide - Organic oxygen compound - Organochloride - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 11.16, Max Conc. mM: 20 Sensitivity light & Moisture sensitive Molecular Weight 558.100 g/mol XLogP3 5.300 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 6 Exact Mass 557.176 Da Monoisotopic Mass 557.176 Da Topological Polar Surface Area 106.000 Ų Heavy Atom Count 39 Formal Charge 0 Complexity 878.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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