Pacmilimab (anti-PD-L1) - Primary antibody, specific to CD274, Human IgG4SP, BINDING AGENT of Programmed cell death 1 ligand 1 binding agent, BINDING AGENT of Programmed cell death 1 ligand 1 binding agent

CAS: 2145091-51-4 Cat. No.: Ab182789

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human, Mouse

Isotype

Human IgG4SP

Conjugation

Unconjugated

Overview

Pacmilimab (anti-PD-L1) is a potent PD-L1 inhibitor. Pacmilimab (anti-PD-L1) shows antitumor activity.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/m

Specifications

Product Name

Pacmilimab (anti-PD-L1) - Primary antibody, specific to CD274, Human IgG4SP, BINDING AGENT of Programmed cell death 1 ligand 1 binding agent

Synonyms

B7 H antibody | B7 H1 antibody | B7 homolog 1 antibody | B7-H1 antibody | B7H antibody | B7H1 antibody | CD 274 antibody | CD-274 antibody | CD274 antibody | CD274 antigen antibody | CD274 molecule antibody | MGC142294 antibody | MGC142296 antibody | OTTH

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

CD274

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

BINDING AGENT

Mechanism of action

BINDING AGENT of Programmed cell death 1 ligand 1 binding agent

Isotype

Human IgG4SP

Light Chain Type

kappa

SDS-PAGE

145 kDa

Purification Method

Protein A purified

Concentration

See COA

CAS

2145091-51-4

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Flow Cytometry: Pacmilimab (anti-PD-L1) (Ab182789)

Pacmilimab (anti-PD-L1) (Ab182789) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling PD-L1 (red) with Pacmilimab (anti-PD-L1) (Ab182789) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Pacmilimab (anti-PD-L1) (Ab182789)

Pacmilimab (anti-PD-L1) (Ab182789) - ELISA
Immobilized Recombinant Human PD-L1 protein (rp169666) at 1.0 μg/mL can bind Pacmilimab (anti-PD-L1) (Ab182789) with the EC ₅₀  of 1.2 μg/mL.

SEC: Pacmilimab (anti-PD-L1) (Ab182789)

Pacmilimab (anti-PD-L1) (Ab182789) - SEC
The purity of Pacmilimab (anti-PD-L1) (Ab182789) is more than 95% verified by HPLC.

Associated Targets(Human)

CD274 Tclin Programmed cell death 1 ligand 1 (0 Activities)

Discover Target: CD274

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action