Sodium Palmitate - ≥97%(GC)(T) , CAS No.408-35-5

CAS: 408-35-5 Cat. No.: S161420 Molecular Weight: 278.41 Beilstein Registry Number: 3575880 EC Number: 206-988-1 PubChem CID: 2735111

GRADE & PURITY ≥97%(GC)(T)

Synonyms

SCHEMBL24894 | sodiumpalmitate | UNII-JQ43KP6296 | SODIUM HEXADECANOATE-D31 | Palmitic acid, sodium salt | E-470(I)PALMITIC ACID, SODIUM SALT | Palmitic acid sodium salt | Sodium hexadecanoate | AS-81680 | C-LUBE 16 | Hexadecanoic acid, sodium salt | EINE

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

SCHEMBL24894 | sodiumpalmitate | UNII-JQ43KP6296 | SODIUM HEXADECANOATE-D31 | Palmitic acid, sodium salt | E-470(I)PALMITIC ACID, SODIUM SALT | Palmitic acid sodium salt | Sodium hexadecanoate | AS-81680 | C-LUBE 16 | Hexadecanoic acid, sodium salt | EINE

Specifications & Purity

≥97%(GC)(T)

Biochemical and Physiological Mechanisms

Sodium palmitate is the sodium salt of palmitic acid, which is a component of hard soap. Palmitic acid is a common fatty acid produced during Fatty acid synthesis. Sodium palmitate can enhance lipogenesis and cellular steatosis in various cells. Palmitic

Storage

Room temperature

Shipped In

Normal

Purity

≥97%(GC)(T)

Names and Identifiers

• Pubchem Sid: 488192703
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488192703
• Canonical Smiles: CCCCCCCCCCCCCCCC(=O)[O-].[Na+]
• IUPAC Name: sodium;hexadecanoate
• InChIKey: GGXKEBACDBNFAF-UHFFFAOYSA-M
• INCHI: 1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1
• Isomeric SMILES: CCCCCCCCCCCCCCCC(=O)[O-].[Na+]
• WGK Germany: 1
• RTECS: RT4945000
• PubChem CID: 2735111
• Molecular Weight: 278.41
• Beilstein: 3575880
• Reaxy-Rn: 3575882

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Long-chain fatty acids
• Alternative Parents: Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Long-chain fatty acid - Carboxylic acid salt - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic sodium salt - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility in hot EtOH(50vol%) very faint turbidity
• Sensitivity: Moisture sensitive
• Melt Point(°C): 283-290 °C (lit.)
• Molecular Weight: 278.410 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 14
• Exact Mass: 278.222 Da
• Monoisotopic Mass: 278.222 Da
• Topological Polar Surface Area: 40.100 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 184.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Han Wenrun, Zhang Dandan, Zhang Peng, Tao Qianqian, Du Xiaoli, Yu Chunquan, Dong Pengzhi, Zhu Yan.  (2023)  Danlou Recipe promotes cholesterol efflux in macrophages RAW264.7 and reverses cholesterol transport in mice with hyperlipidemia induced by P407.  BMC Complementary Medicine and Therapies,  23  (1): (1-14).  [PMID:38066464] [10.1186/s12906-023-04253-9]

2. Tian Xiaorong, Wang Yuxin, Yuan Mengshu, Zheng Weiping, Zuo Huaiwen, Zhang Xinru, Song Hongli.  (2023)  Heme Oxygenase-1-Modified BMMSCs Activate AMPK–Nrf2–FTH1 to Reduce Severe Steatotic Liver Ischemia–Reperfusion Injury.  DIGESTIVE DISEASES AND SCIENCES,      [PMID:37707747] [10.1007/s10620-023-08102-0]

3. Yanzhuo Yang, Qingting Yu, Bin Li, Zuisu Yang, Shuai Zhang, Falei Yuan.  (2023)  Palmitate lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia.  PLoS One,  18  (4): (e0281189).  [PMID:37079515] [10.1371/journal.pone.0281189]

4. Xuebin Gao, Xiaozhuan Lin, Yan Xin, Xuan Zhu, Xiang Li, Ming Chen, Zhigang Huang, Honghui Guo.  (2023)  Dietary cholesterol drives the development of nonalcoholic steatohepatitis by altering gut microbiota mediated bile acid metabolism in high-fat diet fed mice.  JOURNAL OF NUTRITIONAL BIOCHEMISTRY,      [PMID:37031879] [10.1016/j.jnutbio.2023.109347]

5. Jiang Hui, Mao Tangyou, Sun Zhongmei, Shi Lei, Han Xiao, Zhang Yang, Zhang Xiaosi, Wang Jiali, Hu Juncong, Zhang Liming, Li Junxiang, Han Haixiao.  (2022)  Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota.  Frontiers in Microbiology,      [PMID:36578580] [10.3389/fmicb.2022.1001778]

6. Huanhuan Ma, Yunxia Ma, Zeren Dawa, Yufeng Yao, Meiqi Wang, Kaihui Zhang, Chenchen Zhu, Fangle Liu, Chaozhan Lin.  (2022)  Diterpenoid Alkaloids Isolated from Delphinium brunonianum and Their Inhibitory Effects on Hepatocytes Lipid Accumulation.  MOLECULES,  27  (7): (2257).  [PMID:35408656] [10.3390/molecules27072257]

7. Han Jia, Shaoyan Wang, Zhe Wang, Qiang Wang, Haidong Jia, Lin Song, Xuwen Qin, Fangning Fan, Zhe Li, Pan Huang.  (2021)  Investigation of anionic group effects on the shale inhibition performance of fatty acid-based ionic liquids and their inhibition mechanism.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2021.128135]

8. Han Jia, Shaoyan Wang, Yingbiao Xu, Tingyi Wang, Lingyu Zhang, Jinyong Song, Xuehao Zhang, Lin Song, Haidong Jia, Hui Yan.  (2021)  Systematic investigation on the abnormal surface and interfacial activity of fatty acid ionic liquids.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2021.127902]

9. Xian Zheng, Xiao-Gai Zhang, Yao Liu, Li-Ping Zhu, Xiao-Shuang Liang, Hui Jiang, Gao-Feng Shi, Yuan-Yuan Zhao, Zhi-Wei Zhao, Yuan Teng, Ke Pan, Jian Zhang, Zhi-Qi Yin.  (2021)  Arjunolic acid from Cyclocarya paliurus ameliorates nonalcoholic fatty liver disease in mice via activating Sirt1/AMPK, triggering autophagy and improving gut barrier function.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2021.104686]

10. Baogui Wang, Lumin Li, Jing Fu, Ping Yu, Deming Gong, Cheng Zeng, Zheling Zeng.  (2016)  Effects of Long-Chain and Medium-Chain Fatty Acids on Apoptosis and Oxidative Stress in Human Liver Cells with Steatosis.  JOURNAL OF FOOD SCIENCE,  81  (3): (H794).  [PMID:26799523] [10.1111/1750-3841.13210]

11. Yuan Qianhua, Luo Mengliu, Xie Yutong, Song Wanhan, Wang Ya, Deng Dazhang, Chen Shuyan, Guo Honghui.  (2024)  Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet.  BIOGERONTOLOGY,      [PMID:38582786] [10.1007/s10522-024-10101-1]

12. Xiaoping Liang, Jiehua Liang, Shengqi Zhang, Haowei Yan, Tiangang Luan.  (2024)  Di-2-ethylhexyl phthalate disrupts hepatic lipid metabolism in obese mice by activating the LXR/SREBP-1c and PPAR-α signaling pathways.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:38199361] [10.1016/j.scitotenv.2024.169919]

13. Maoshan Wang, Yingxue Liu, Houda Gui, Gaoqiang Ma, Binyang Li, Zhanwei Zhang, Gyeonghwi Yu, Ailin Wu, Xin Xu, Dongjiao Zhang.  (2024)  ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:38211715] [10.1016/j.ejphar.2023.176303]

14. Yun Wang, Jiawei Wu, Yu Hong, Jiaying Zhu, Youcai Zhang, Jun Zhang, Chujie Ding, Yuan Che, Guangji Wang, Aiqin Jiang, Haiping Hao, Lijuan Cao.  (2024)  Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis.  BRITISH JOURNAL OF PHARMACOLOGY,      [PMID:38355288] [10.1111/bph.16320]

15. Qingting Yu, Yanzhuo Yang, Ting Xu, Yinsheng Cai, Zuisu Yang, Falei Yuan.  (2024)  Palmitoleic acid protects microglia from palmitate-induced neurotoxicity in vitro.  PLoS One,  19  (1): (e0297031).  [PMID:38241239] [10.1371/journal.pone.0297031]

16. Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan.  (2025)  Berberine–cinnamic acid co-crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP-1 signaling pathway.  FEBS Open Bio,      [PMID:40928061] [10.1002/2211-5463.70115]

17. Baogui Wang, Jing Fu, Lumin Li, Deming Gong, Xuefang Wen, Ping Yu, Zheling Zeng.  (2016)  Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.  INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION,      [PMID:26932533] [10.3109/09637486.2016.1153611]

18. Qianhua Yuan, Wanhan Song, Ya Wang, Yutong Xie, Dazhang Deng, Nageena Qayyum, Huawen Li, Honghui Guo.  (2025)  Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis.  Journal of Agriculture and Food Research,      [PMID:] [10.1016/j.jafr.2025.102138]

19. Shuang Pan, Mengshu Yu, Bowei Fan, Bin Wang, Xinrui Yang, Jiawen Zhang, Xiaoqi Liu, Xiaojian Hong, Wei Yang.  (2025)  Hydrogen protects against autoimmune myocarditis by inhibiting necroptosis via the TNF/TNFR1 signalling pathway.  CLINICAL IMMUNOLOGY,      [PMID:40812663] [10.1016/j.clim.2025.110577]

20. Bing Li, Pengjun Zhong, Xueling Zhang, Chengguo Li, Min Luan, Yanlin Chen, Lei Chen, Wu Li, Rihui Wu.  (2025)  CYP4A14-PPARα axis serves as a therapeutic target for ursodeoxycholic acid in ameliorating high-fat diet-induced MASLD.  JOURNAL OF NUTRITIONAL BIOCHEMISTRY,      [PMID:41061809] [10.1016/j.jnutbio.2025.110138]

21. Yingwei Liu, Yunpeng Sun, Ting Zhou, Xiao Huang, Guokai Wang, Lijuan Sun.  (2025)  Lipid-lowering mechanism of Swietenia macrophylla King leaves through SREBP-1c/FASN axis and RNA sequencing validation.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107860]

22. Jinlu Han, Jiong Chen, Hong Hu, Yun Song, Mengyan Chen, De Zhao, Wen Shan, Qinghui Zhang, Ling Xu.  (2025)  Moronic acid alleviates non-alcoholic fatty liver disease and fibrosis through PPARs-mediated lipidomic reprogramming.  PHYTOMEDICINE,      [PMID:41242309] [10.1016/j.phymed.2025.157519]

23. Guowei Zhu, Junqing Yang, Dongzhi Ran, Ying Luo, Yanyi Wang, Wenjia Guo, Xiaodan Tan, Xiaobing Zhao, Yuanhong Gan, Huafeng Yin, Hong Wang.  (2026)  METTL3-m6A-MALAT1 axis exacerbates the autophagy impairment and lipid accumulation in NAFLD by regulating miR-690.  BIOCHEMICAL PHARMACOLOGY,      [PMID:41690413] [10.1016/j.bcp.2026.117806]

24. Zhi Yang, Usman Nazir, Xinfang Wang, Xucheng Zheng, Haiming Yang, Zhiyue Wang.  (2026)  Effects of Betaine on DNA Methylation Level, Expression Level, and Fat Synthesis of VNN1 in Goose Hepatocytes.  Animals,  16  (4):   [PMID:41751030] [10.3390/ani16040570]

25. Wen Jiang, Chen Ye, Ting Hu, Jichao Liang, Yong Chen.  (2026)  Costunolide Ameliorates Hepatic Steatosis and Insulin Resistance in a Diet-Induced Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK/ACC1 Signalling Pathway.  PHYTOTHERAPY RESEARCH,      [PMID:] [10.1002/ptr.70302]