Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C,Avoid repeated freezing and thawing Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Talacotuzumab (anti-IL-3Ra) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab (anti-IL-3Ra) has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab (anti-IL-3Ra) inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab (anti-IL-3Ra) has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab (anti-IL-3Ra) is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.
Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra (red) with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Talacotuzumab (anti-IL-3Ra) (Ab177880) - SEC
The purity of Talacotuzumab (anti-IL-3Ra) (Ab177880) is more than 95% verified by HPLC.
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0404125 | Certificate of Analysis | Feb 10, 2026 | Ab177880 |
| ZJ24F0404126 | Certificate of Analysis | Feb 10, 2026 | Ab177880 |
| ZJ24F0404127 | Certificate of Analysis | Feb 10, 2026 | Ab177880 |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Animal Free grade guide → View Carrier Free grade guide → View Recombinant grade guide → View Validated grade guide → View ExactAb™ grade guide → View Low Endotoxin grade guide → View Azide Free grade guide →
