Tricine - Anhydrous Grade, ≥99% , CAS No.5704-04-1

CAS: 5704-04-1 Cat. No.: T485457 Molecular Weight: 179.17 Beilstein Registry Number: 1937804 EC Number: 227-193-6 PubChem CID: 79784
AVAILABLE TO ORDER
GRADE & PURITY Anhydrous Grade ? Anhydrous grade — water removed and packaged dry for moisture-sensitive chemistry. Use in reactions where even trace water would interfere or quench. ≥99%
Synonyms
N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine | N-(Tri(hydroxymethyl)methyl)glycine | Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]- | N-Tris(hydroxymethyl)methylglycine | N-[Tris(hydroxymethyl)methyl]glycine
Storage
Room temperature
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
100g
T485457-100g
2

$181.90

$213.90
Save $32.00 (14.96%)
500g
T485457-500g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

$868.90

$1,014.90
Save $146.00 (14.39%)
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Anhydrous Grade, ≥99% Anhydrous Grade for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 15 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Description

Buffer component for separation of low molecular weight peptides.

Specifications

Synonyms
N-[2-hydroxy-1, 1-bis(hydroxymethyl)ethyl]glycine | N-(Tri(hydroxymethyl)methyl)glycine | Glycine, N-[2-hydroxy-1, 1-bis(hydroxymethyl)ethyl]- | N-Tris(hydroxymethyl)methylglycine | N-[Tris(hydroxymethyl)methyl]glycine
Specifications & Purity
Anhydrous Grade, ≥99%
Storage
Room temperature
Grade
Anhydrous Grade
Purity
≥99%
Names and Identifiers
Canonical SmilesC(C(=O)O)NC(CO)(CO)CO
IUPAC Name2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
InChIKeySEQKRHFRPICQDD-UHFFFAOYSA-N
INCHI1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)
Isomeric SMILES C(C(=O)O)NC(CO)(CO)CO
WGK Germany 3
PubChem CID 79784
Molecular Weight 179.17
Beilstein 1937804
Reaxy-Rn 1937804

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct ParentAlpha amino acids
Alternative Parents Amino acids  1,2-aminoalcohols  Monocarboxylic acids and derivatives  Dialkylamines  Carboxylic acids  Primary alcohols  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic acyclic compounds
Substituents Alpha-amino acid - 1,2-aminoalcohol - Amino acid - Carboxylic acid - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Secondary amine - Organic nitrogen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Carbonyl group - Amine - Organic oxygen compound - Alcohol - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
External Descriptors tricine
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
D2416028Certificate of AnalysisApr 28, 2024 T485457
D2416029Certificate of AnalysisApr 23, 2024 T485457
Chemical and Physical Properties
Solubility water: 20% (w/w), clear, colorless
Melt Point(°C)172 °C
Molecular Weight179.170 g/mol
XLogP3-5.100
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass179.079 Da
Monoisotopic Mass179.079 Da
Topological Polar Surface Area110.000 Ų
Heavy Atom Count12
Formal Charge0
Complexity137.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Ziwei Su, Xiangxiang Zhang, Weichen Wang, Mingdong Dong, Xiaojun Han.  (2022)  Light-Harvesting Artificial Cells for the Generation of ATP and NADPH†.  CHINESE JOURNAL OF CHEMISTRY,  41  (1): (57-63).  [PMID:] [10.1002/cjoc.202200482]
2. Ping Sun, Jing Wu, Shenghong Yang, Hongli Li, Lei Zhao, Yuanhang Wang, Xiayan Wang, Qiaosheng Pu.  (2021)  Robust and easy-to-use microchip electrophoresis within sub-millimeter channels for fast and highly efficient separation.  TALANTA,      [PMID:34517615] [10.1016/j.talanta.2021.122747]
3. Yongjia Tang, Haoran Xu, Yaxue Dai, Fang Wang, Wenjing Huang, Peifei Liu, Yueqing Gu.  (2021)  A novel peptide targeting c-Met for hepatocellular carcinoma diagnosis.  Journal of Materials Chemistry B,  (22): (4577-4586).  [PMID:34047746] [10.1039/D1TB00408E]
4. Yuanbiao Tu, Ji Tao, Fang Wang, Peifei Liu, Zhihao Han, Zhaolun Li, Yi Ma, Yueqing Gu.  (2020)  A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection.  Biomaterials Science,  (9): (2682-2693).  [PMID:32266897] [10.1039/D0BM00162G]
5. Wei Zong, Xunan Zhang, Chao Li, Xiaojun Han.  (2018)  Thylakoid Containing Artificial Cells for the Inhibition Investigation of Light-Driven Electron Transfer during Photosynthesis.  ACS Synthetic Biology,      [PMID:29439569] [10.1021/acssynbio.8b00045]
6. Le Pan, Yanjie Li, Lin Zhu, Buchang Zhang, Yuhua Shen, Anjian Xie.  (2017)  A novel composite hydrogel initiated by Spinacia oleracea L. extract on Hela cells for localized photodynamic therapy.  Materials Science & Engineering C-Materials for Biological Applications,      [PMID:28415436] [10.1016/j.msec.2017.03.021]
7. Hui Ai, Yang Wang, Bao Li, Lixin Wu.  (2014)  Synthesis and Characterization of Single-Side Organically Grafted Anderson-Type Polyoxometalates.  EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,  2014  (17): (2766-2772).  [PMID:] [10.1002/ejic.201301596]
8. Ming Liu, Zhicun Liu, Xiangkai Qiao, Cheng Chen, Hongtu Guo, Hao Gu, Junbo Li, Tiedong Sun.  (2025)  An Endogenous Proton-Powered Adaptive Nanomotor for Treating Muscle Atrophy.  Materials,  18  (6): (1351).  [PMID:40141635] [10.3390/ma18061351]
9. Cong Rao, Chao Yuan, Wangjin He, Hailiang Guo, Kuitun Liu, Jianfeng Fan, Jianya Su.  (2025)  Flavin-Containing Monooxygenases Mediate Resistance to Nereistoxin Insecticides in Lepidopteran Pests: Insights into Conserved Tertiary Amine Oxidation Mechanisms.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:40123365] [10.1021/acs.jafc.5c01818]
10. Yuxuan He, Zhiguang Guo.  (2024)  Natural polymers-based separation membrane for high-efficient separation of oil water mixture.  Nano Today,      [PMID:] [10.1016/j.nantod.2024.102367]
11. Yiren Cao, Youli Tian, Ke-Er Chen, Yixin Ma, Qiang Zhang, Weiwen Liu, Zhishen Mu, Shengpeng Su, Chengxi Cao.  (2025)  Specific glycomacropeptide detection via polyacrylamide gel electrophoresis with dual imaging and signal-fusion deep learning.  FOOD CHEMISTRY,      [PMID:39986063] [10.1016/j.foodchem.2025.143293]
12. Bang Lou, Hongzhou Liu, Weiyong Hong, Qingliang Yang, Hanbing Li, Gensheng Yang.  (2025)  Adsorption and Separation of the Biomolecular Motors of FOF1-ATPase-Embedded Chromatophores Using Titanium Dioxide Microsphere.  Biotechnology Journal,  20  (8): (e70093).  [PMID:40776535] [10.1002/biot.70093]
13. Sun Yu-Long, Ge Bing-Qiang, Li Mi-Zhuan, Wang Lei, Chen Zhong-Xiu.  (2023)  The effect of macromolecular crowding degree on the self-assembly of fatty acid and lipid hydrolysis.  npj Science of Food,  (1): (1-8).  [PMID:37495579] [10.1038/s41538-023-00213-2]
14. Guanru Chang, Yunlong Wang, Baoyou Gong, Yazhong Xiao, Yan Chen, Shaohua Wang, Shikuo Li, Fangzhi Huang, Yuhua Shen, Anjian Xie.  (2015)  Reduced Graphene Oxide/Amaranth Extract/AuNPs Composite Hydrogel on Tumor Cells as Integrated Platform for Localized and Multiple Synergistic Therapy.  ACS Applied Materials & Interfaces,      [PMID:25978657] [10.1021/acsami.5b03907]
15. Chao Gao, Ye Feng, Suyi Liu, Bin Chen, Miaomiao Ding, Dailing Du, Wenjing Zhang, Daniela A. Wilson, Yingfeng Tu, Fei Peng.  (2025)  Light-Driven Artificial Cell Micromotors for Degenerative Knee Osteoarthritis.  ADVANCED MATERIALS,      [PMID:40025988] [10.1002/adma.202416349]
Solution Calculators
Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.