Bleselumab (anti-CD40) - Anticorpo primario, specific to CD40, Human IgG4SP, INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor, INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor

CAS: 1453067-91-8 Cat. No.: Ab182780
Disponibile su ordine
QUALITÀ & PUREZZA Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Umano
Reactive species
Cynomolgus monkey, Umano
Isotype
Human IgG4SP
Conjugation
Unconjugated
★
Dimensione
Germania (EU)
USA*
Prezzo
Qtà
100μg
Ab182780-100μg
—
Disponibile ≥10
100,57€
1mg
Ab182780-1mg
—
4 Disponibile
496,26€
5mg
Ab182780-5mg
—
1 Disponibile
1.301,52€
10mg
Ab182780-10mg
Su ordinazione · 8–12 settimane
2.082,49€
Enter a quantity for the sizes you want to add.
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Perché questa qualità

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated per flussi di lavoro cromatografici e analitici sensibili che richiedono un'interferenza minima della linea di base.

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Stoccaggio e spedizione

Store at -80°C,Avoid repeated freezing and thawing Spedizione Dry ice packs + Cold packs. Consultare il COA specifico del lotto per le specifiche esatte.

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Documenti di qualità

SDS, COA, scheda tecnica e scheda delle specifiche disponibili per il download. COA specifico del lotto accessibile tramite ricerca per numero di lotto.

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Prova documentale

Citato in 0 pubblicazioni peer-reviewed su cromatografia, sintesi organica e reazioni di accoppiamento incrociato.

Panoramica

Bleselumab (anti-CD40) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab (anti-CD40) binds to human CD40 with high affinity (Kd:  0.24 nM). Bleselumab (anti-CD40) inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab (anti-CD40) prevents organ transplant rejection.

Purity

>95% (SDS-PAGE&SEC)

Endotoxin Level

< 1.0EU/mg

Specifiche

Product Name
Bleselumab (anti-CD40) - Anticorpo primario, specific to CD40, Human IgG4SP, INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor
Sinonimi
AI326936 antibody | B cell associated molecule CD40 antibody | B cell surface antigen CD40 antibody | B cell-associated molecule antibody | B-cell surface antigen CD40 antibody | Bp50 antibody | CD 40 antibody | CD40 antibody | CD40 antigen (TNF receptor
Specifiche e purezza
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Specie ospite
Umano
Specificità
CD40
Coniugazione
Unconjugated
Grado
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Tipo di azione
INHIBITOR
Meccanismo d'azione
INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor
Isotipo
Human IgG4SP
Tipo di catena leggera
kappa
SDS-PAGE
25.8 kDa (Light Chain) & 53.0 kDa (Heavy Chain), under reducing conditions; 186.9 kDa, under non-reducing conditions.
Metodo di purificazione
Protein A purified
Concentrazione
See COA
CAS
1453067-91-8
Product Line
Prodotti biologici
Stoccaggio e spedizione
Forma
Liquid
Condizioni di conservazione di stoccaggio
Store at -80°C,Avoid repeated freezing and thawing
Spedito in
Dry ice packs + Cold packs
Stabilità e conservazione
Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
Immagini

Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 with Bleselumab (anti-CD40) (Ab182780) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Bleselumab (anti-CD40) (Ab182780) - SEC
The purity of Bleselumab (anti-CD40) (Ab182780) is more than 95% verified by HPLC.

Bleselumab (anti-CD40) (Ab182780) - ELISA
Immobilized Recombinant Human CD40 protein (rp144000) at 1.0 μg/mL can bind Bleselumab (anti-CD40) (Ab182780) with the EC50 of 27.51 ng/mL.

Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Bleselumab (anti-CD40) (Ab182780). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 (red) with Bleselumab (anti-CD40) (Ab182780) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of U-2 OS cells labelling CD40 (red) with Bleselumab (anti-CD40) (Ab182780). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Documentazione

📋 Scheda di dati di sicurezza (SDS)

Documento completo su pericoli, manipolazione, stoccaggio e conformità normativa.

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✅ Certificato di analisi (COA)

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Dati avanzati

Obiettivi associati (umani)
CD40 Tchem Tumor necrosis factor receptor superfamily member 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CD40 Tchem Tumor necrosis factor receptor superfamily member 5 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meccanismi d'azione
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDataOggetto
ZJ24F0505997ZJ24F0505997Certificate of AnalysisMar 19, 2026 Ab182780
ZJ24F0505998ZJ24F0505998Certificate of AnalysisMar 19, 2026 Ab182780
ZJ24F0505999ZJ24F0505999Certificate of AnalysisMar 19, 2026 Ab182780
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