Mitazalimab (anti-CD40) - Anticorpo primario, specific to CD40, Human IgG1

CAS: 2055640-86-1 Cat. No.: Ab182809

QUALITÀ & PUREZZA Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Umano

Reactive species

Cynomolgus monkey, Umano

Isotype

Human IgG1

Conjugation

Unconjugated

Panoramica

Mitazalimab (anti-CD40) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab (anti-CD40) activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab (anti-CD40) induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab (anti-CD40) remodels the tumor-infiltrating myeloid microenvironment.
Purity>95% (SDS-PAGE&SEC)
Endotoxin Level < 0.01EU/μg

Specifiche

Product Name

Mitazalimab (anti-CD40) - Anticorpo primario, specific to CD40, Human IgG1

Specifiche e purezza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Specie ospite

Umano

Specificità

CD40

Coniugazione

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo di azione

INHIBITOR

Isotipo

Human IgG1

Tipo di catena leggera

lambda

SDS-PAGE

143.44 kDa

Metodo di purificazione

Protein A purified

Concentrazione

See COA

CAS

2055640-86-1

Product Line

Prodotti biologici

Stoccaggio e spedizione

Forma

Liquid

Condizioni di conservazione di stoccaggio

Store at -80°C,Avoid repeated freezing and thawing

Spedito in

Dry ice packs + Cold packs

Stabilità e conservazione

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Immagini

Flow Cytometry: Mitazalimab (anti-CD40) (Ab182809)

Mitazalimab (anti-CD40) (Ab182809) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Mitazalimab (anti-CD40) (Ab182809). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Mitazalimab (anti-CD40) (Ab182809)

Mitazalimab (anti-CD40) (Ab182809) - Flow Cytometry
Flow Cytometry analysis of U2OS cells labelling CD40 (red) with Mitazalimab (anti-CD40) (Ab182809). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Mitazalimab (anti-CD40) (Ab182809)

Mitazalimab (anti-CD40) (Ab182809) - ELISA
Immobilized Recombinant Human CD40 protein (rp183577) at 1.0 μg/mL can bind Mitazalimab (anti-CD40) (Ab182809) with the EC50 of 4.37 ng/mL.

SEC: Mitazalimab (anti-CD40) (Ab182809)

Mitazalimab (anti-CD40) (Ab182809) - SEC
The purity of Mitazalimab (anti-CD40) (Ab182809) is more than 95% verified by HPLC.

Obiettivi associati (umani)

CD40 Tchem Tumor necrosis factor receptor superfamily member 5 (0 Activities)

Discover Target: CD40

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CD40 Tchem Tumor necrosis factor receptor superfamily member 5 (9 Activities)

Discover Target: CD40

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Domande frequenti

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2055640-86-1.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Mitazalimab (anti-CD40)); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.