Ficlatuzumab (anti-HGF) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to HGF, >95%, Human IgG1, INHIBITOR of Hepatocyte growth factor inhibitor, INHIBITOR of Hepatocyte growth factor inhibitor

CAS: 1174900-84-5 Cat. No.: Ab170563

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human

Isotype

Human IgG1

Conjugation

Unconjugated

Overview

Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion.

Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Ficlatuzumab (anti-HGF) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to HGF, >95%, Human IgG1, INHIBITOR of Hepatocyte growth factor inhibitor

Synonyms

Hepatopoietin-A | Scatter factor | SF

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

HGF

Application

ELISA, Functional Assay, Flow cytometry, Kinetics (BLI), Kinetics (SPR)

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

INHIBITOR

Mechanism of action

INHIBITOR of Hepatocyte growth factor inhibitor

Antibody Type

Primary antibody

Clonality

Recombinant

Isotype

Human IgG1

Light Chain Type

kappa

SDS-PAGE

27.6 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 178.7 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Source

CHO supernatant

Concentration

See COA

CAS

1174900-84-5

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

ELISA: Ficlatuzumab (anti-HGF) (Ab170563)

Ficlatuzumab (anti-HGF) (Ab170563) - ELISA
Immobilized Recombinant human HGF protein (rp156180) at 1.0 μg/mL can bind Ficlatuzumab (anti-HGF) (Ab170563) with the EC₅₀ of 45.64 ng/mL.

SEC: Ficlatuzumab (anti-HGF) (Ab170563)

Ficlatuzumab (anti-HGF) (Ab170563) - SEC
The purity of Ficlatuzumab (anti-HGF) (Ab170563) is more than 95% verified by HPLC.

Associated Targets(Human)

HGF Tchem Hepatocyte growth factor (0 Activities)

Discover Target: HGF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

References

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2. Shanmeiyu Zhang, Yanyan Zhang, Chongchong Wu, Hui Yang, Qiqi Zhang, Fuyi Wang, Jingyi Wang, Ian Gates, Jinben Wang.  (2021)  A Facile Strategy to Prepare Small Water Clusters via Interacting with Functional Molecules.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  22  (15): (8250).  [PMID:34361016] [10.3390/ijms22158250]

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6. Xiu-Qing Qiao, Zhen-Wei Zhang, Qiu-Hao Li, Dongfang Hou, Qichun Zhang, Jian Zhang, Dong-Sheng Li, Pingyun Feng, Xianhui Bu.  (2018)  In situ synthesis of n–n Bi2MoO6 & Bi2S3 heterojunctions for highly efficient photocatalytic removal of Cr(VI).  Journal of Materials Chemistry A,  6  (45): (22580-22589).  [PMID:] [10.1039/C8TA08294D]

7. Yiwen Zhang, Zixuan Tang, Liyun Chen, Min Yang, Yating Zeng, Xujue Bai, Bingna Zhang, Jianda Zhou, Wancong Zhang, Shijie Tang.  (2025)  Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing.  JOURNAL OF CONTROLLED RELEASE,      [PMID:39724946] [10.1016/j.jconrel.2024.12.055]

8. Junpeng Liu, Wei Liu, Yefan Zhang, Junwen Ouyang, Boxiao Zhao, Changyu Wu, Boda Li, Jiaxuan Jiang, Kai Hu.  (2025)  Injectable High-Adhesion Fibrinogen-Silk Fibroin Hydrogel Loaded with Curcumin Accelerates Pterygium Repair via Dual Anti-Inflammatory/Antiproliferative Mechanisms.  ACS Applied Materials & Interfaces,      [PMID:40910581] [10.1021/acsami.5c12778]

9. Jiahang Yu, Mingyuan Huang, Huixin Tian, Xinglian Xu.  (2023)  Silver Nanoparticle Sensor Array-Based Meat Freshness Inspection System.  Foods,  12  (20): (3814).  [PMID:37893707] [10.3390/foods12203814]