Tiragolumab (anti-TIGIT) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to TIGIT, >95%, Human IgG1, INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor, INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor

CAS: 1918185-84-8 Cat. No.: Ab169250

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human, Rabbit

Isotype

Human IgG1

Conjugation

Unconjugated

Overview

Tiragolumab is a humanized IgG1/kappa monoclonal antibody that binds TIGIT to prevent its interaction with its ligand PVR (CD155).

Purity

>95% (SDS-PAGE&SEC)

Endotoxin Level

< 1.0EU/mg 

Specifications

Product Name

Tiragolumab (anti-TIGIT) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to TIGIT, >95%, Human IgG1, INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor

Synonyms

RG6058 | MTIG7192A | T cell immunoreceptor with Ig and ITIM domains | TIGIT | VSIG9 | VSTM3 | WUCAM | DKFZp667A205 antibody | ENSMUSG00000071552 antibody | FLJ39873 antibody | RGD1563191 antibody | T cell immunoreceptor with Ig and ITIM domains antibody |

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

TIGIT

Application

ELISA, Functional Assay, Kinetics (BLI), Kinetics (SPR), Flow Cyt

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

INHIBITOR

Mechanism of action

INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor

Antibody Type

Primary antibody

Clonality

Recombinant

Isotype

Human IgG1

Light Chain Type

kappa

SDS-PAGE

26.9 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 176.5 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Source

CHO supernatant

Concentration

See COA

CAS

1918185-84-8

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

ELISA: Tiragolumab (anti-TIGIT) (Ab169250)

Tiragolumab (anti-TIGIT) (Ab169250) - ELISA
Immobilized Recombinant Human TIGIT Protein at 2 μg/mL can bind Tiragolumab (anti-TIGIT) (Ab169250) with the EC50 of 16.43 ng/mL.

SEC: Tiragolumab (anti-TIGIT) (Ab169250)

Tiragolumab (anti-TIGIT) (Ab169250) - SEC
The purity of Tiragolumab (anti-TIGIT) (Ab169250) is more than 95% verified by HPLC.

Associated Targets(Human)

TIGIT Tbio T-cell immunoreceptor with Ig and ITIM domains (0 Activities)

Discover Target: TIGIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

References

1. Yazhen Liu, Jiaqi Huang, Ji Yu, Luxin Fu, Ronglong Huang, Jing Liu, Bailin Deng, You-Bao Zhong, Duanyong Liu, Haimei Zhao.  (2025)  Curcumin Modulates TIGIT/Neuropilin-1 to Regulate T-Cell Immune Homeostasis in Ulcerative Colitis.  Foods,  14  (24): (4323).  [PMID:41465029] [10.3390/foods14244323]