L-Leucine - Animal Free, USP, JP, Moligand™, Ph.Eur., for cell culture, ≥98.5% , CAS No.61-90-5

CAS: 61-90-5 Cat. No.: L774643 Formula: C₆H₁₃NO₂ Molecular Weight: 131.17 Beilstein Registry Number: 4437 EC Number: 200-522-0

GRADE & PURITY Animal Free, USP, JP, Moligand™, Ph.Eur., for Cell culture, ≥98.5%

Storage

Protected from light,Room temperature,Desiccated

Shipped In

Normal

Overview

L-leucine has been used as a hypertrophic agent to monitor its effects on myotubes. It has also been used as a component of PMG media for culturing yeast.

Specifications

Specifications & Purity

Animal Free, USP, JP, Moligand™, Ph.Eur., for cell culture, ≥98.5%

Biochemical and Physiological Mechanisms

Leucine is a non sugar producing essential amino acid. It is a branched chain amino acid and a structural component of proteins. Leucine can have a positive effect on the release of insulin, thereby eliminating toxic sugars in the blood. The degradation o

Storage

Protected from light,Room temperature,Desiccated

Shipped In

Normal

Grade

Animal Free, for Cell culture, JP, Moligand™, Ph.Eur., USP

Purity

≥98.5%

Names and Identifiers

Canonical Smiles

CC(C)CC(C(=O)O)N

IUPAC Name

(2S)-2-amino-4-methylpentanoic acid

InChIKey

ROHFNLRQFUQHCH-YFKPBYRVSA-N

INCHI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

Isomeric SMILES

CC(C)C[C@@H](C(=O)O)N

WGK Germany

1

Molecular Weight

131.17

Beilstein

4437

Reaxy-Rn

636005

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=636005&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Leucine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Leucine and derivatives
• Alternative Parents: L-alpha-amino acids Methyl-branched fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Leucine or derivatives - Alpha-amino acid - L-alpha-amino acid - Branched fatty acid - Methyl-branched fatty acid - Fatty acid - Fatty acyl - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxide - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Common amino acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: 18.9 g/L
• Sensitivity: Sensitive to light; Sensitivity to humidity
• Specific Rotation[α]: [α]20/D +15.5±0.5°, c = 5% in 5 M HCl
• Boil Point(°C): 122-134 °C
• Melt Point(°C): 270-340 °C (decomposition)
• Molecular Weight: 131.170 g/mol
• XLogP3: -1.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.095 Da
• Monoisotopic Mass: 131.095 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 101.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1