Lipopolysaccharides from Pseudomonas aeruginosa 10 - Moligand™, purified by trichloroacetic acid extraction, used for Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate, Agonist of TLR4

CAS: L611586 Cat. No.: L611586

GRADE & PURITY Moligand™, purified by trichloroacetic acid extraction

Synonyms

Lipopolysaccharides

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

This product is TCA extracted from Pseudomonas aeruginosa serotype 10. The source strain is ATCC 27316. 

Preparation Note

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Specifications

Synonyms

Lipopolysaccharides

Specifications & Purity

Moligand™, purified by trichloroacetic acid extraction

Biochemical and Physiological Mechanisms

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and li

Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein fami

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of TLR4

Associated Targets(Human)

TLR4 Tchem Toll-like receptor 4 (0 Activities)

Discover Target: TLR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: water: 4.90-5.10 mg/mL, hazy to turbid, colorless to light yellow