SB-431542 - Moligand™,≥99% , CAS No.301836-41-9

CAS: 301836-41-9 Cat. No.: S1371574-GMP Molecular Weight: 384.39 EC Number: 188-365-3

GRADE & PURITY Moligand™, ≥99%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

SB-431542 (GMP) is a GMP grade SB-431542. GMP grade small molecules can be used as auxiliary reagents in cell therapy. SB-431542 is a TGF - β receptor kinase inhibitor in SMAD signaling.

Specifications

Specifications & Purity

Moligand™, ≥99%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
• IUPAC Name: 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
• InChIKey: FHYUGAJXYORMHI-UHFFFAOYSA-N
• INCHI: 1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
• Isomeric SMILES: C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
• Molecular Weight: 384.39

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azoles
      • Subclass Imidazoles
        • Level5 Substituted imidazoles
          • Level6 Phenylimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Substituted imidazoles
• Direct Parent: Phenylimidazoles
• Alternative Parents: Benzodioxoles Benzamides Benzoyl derivatives 2,4,5-trisubstituted imidazoles Pyridines and derivatives Heteroaromatic compounds Primary carboxylic acid amides Oxacyclic compounds Azacyclic compounds Acetals Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 2-phenylimidazole - Benzamide - Benzodioxole - Benzoic acid or derivatives - 2,4,5-trisubstituted-imidazole - Benzoyl - Trisubstituted imidazole - Monocyclic benzene moiety - Benzenoid - Pyridine - Heteroaromatic compound - Primary carboxylic acid amide - Carboxamide group - Oxacycle - Acetal - Azacycle - Carboxylic acid derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: light sensitive；Moisture sensitive
• Melt Point(°C): 214 °C(dec.)

References

1. Jinyue Zhu, Weiqing Wang, Xia Wu.  (2019)  Isorhynchophylline exerts anti-asthma effects in mice by inhibiting the proliferation of airway smooth muscle cells: The involvement of miR-200a-mediated FOXC1/NF-κB pathway.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:31733831] [10.1016/j.bbrc.2019.10.178]

2. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou.  (2018)  Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro.  Experimental and Therapeutic Medicine,  17  (1): (251-259).  [PMID:30651790] [10.3892/etm.2018.6909]

3. Huan Chen, Jin Liu, Jia Zhang, Yuqian Chen, Yan Wang, Yuanjie Qiu, Huizhong Hu, Limin Chai, Qianqian Zhang, Qingting Wang, Manxiang Li.  (2025)  USP22/BRD4 mediated hedgehog pathway activation contributes to airway remodeling in asthma.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:40132456] [10.1016/j.intimp.2025.114538]