306Oi10 - ≥98% , CAS No.2322290-93-5

CAS: 2322290-93-5 Cat. No.: O647772 Formula: C₅₉H₁₁₅N₃O₈ Molecular Weight: 994.56

GRADE & PURITY ≥98%

Synonyms

Tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Application

Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Overview

306Oi10 is a biodegradable, branched chain lipidoid developed for RNA delivery in lipid nanoparticles (LNPs). Interestingly, the unbranched analog was 10-fold less effective in delivering luciferase mRNA in mice. The increased potency is thought to be due to increased cone-shaped structure and protonation at endosomal pH resulting in enhanced endosomal escape. 306Oi10 has been used to co-deliver three mRNAs (firefly luciferase, mCherry, and erythropoietin). The LNPs derived from 306Oi10 were not immunogenic or toxic to the liver. Incorporation of DOTAP into 306Oi10 LNPs resulted in increased targeting of mRNA to pancreatic β cells via intraperitoneal injection in mice.

Specifications

Synonyms

Tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

306Oi10 is a branched-chain ionizable lipidoid that can be used for constructing lipid nanoparticles (LNPs) for the delivery of messenger RNA.

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Product Line

O647772-10mg

Names and Identifiers

Molecular Weight

994.56

Chemical and Physical Properties

• Sensitivity: Moisture sensitive