Bleomycin Sulfate(mixture) - 1.5-2.0 units/mg , CAS No.9041-93-4

CAS: 9041-93-4 Cat. No.: B107423 EC Number: 232-925-2

GRADE & PURITY 1.5-2.0 units/mg

Synonyms

SR-01000941586-2 | Bleomycin, sulfate (salt) | Bleomycin sulfate | AKOS022190415 | Bleomycin, sulfate | AKOS015896273 | Bleomycin sulfate (salt) | Bleomycin sulfate [Bleomycins] | Blexane | 7DP3NTV15T | Bleomycin sulfate [USAN:USP:JAN] | Blenoxane | EINEC

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Product Application:

Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent.

Specifications

Synonyms

SR-01000941586-2 | Bleomycin, sulfate (salt) | Bleomycin sulfate | AKOS022190415 | Bleomycin, sulfate | AKOS015896273 | Bleomycin sulfate (salt) | Bleomycin sulfate [Bleomycins] | Blexane | 7DP3NTV15T | Bleomycin sulfate [USAN:USP:JAN] | Blenoxane | EINEC

Specifications & Purity

1.5-2.0 units/mg

Biochemical and Physiological Mechanisms

An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective clea

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

• Canonical Smiles: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
• IUPAC Name: 3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate
• InChIKey: WUIABRMSWOKTOF-OCBSMOPSSA-N
• INCHI: 1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1
• Isomeric SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
• WGK Germany: 3
• RTECS: EC5991990
• Reaxy-Rn: 24931218
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24931218&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Peptidomimetics
      • Subclass Hybrid peptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Peptidomimetics
• Subclass: Hybrid peptides
• Intermediate Tree Nodes: Not available
• Direct Parent: Hybrid glycopeptides
• Alternative Parents: Histidine and derivatives Fatty acyl glycosides of mono- and disaccharides N-acyl-alpha amino acids and derivatives Alpha amino acid amides Gamma amino acids and derivatives Beta amino acids and derivatives O-glycosyl compounds Disaccharides Pyrimidinecarboxylic acids and derivatives 2-heteroaryl carboxamides Thiazolecarboxamides Aminopyrimidines and derivatives Aralkylamines 2,4-disubstituted thiazoles Imidolactams N-acyl amines Oxanes Heteroaromatic compounds Imidazoles Organic sulfuric acids and derivatives Carbamate esters Secondary carboxylic acid amides Secondary alcohols Primary carboxylic acid amides Organic carbonic acids and derivatives Oxacyclic compounds Acetals Dialkylamines Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Organic salts Organic zwitterions Organopnictogen compounds Organosulfur compounds Primary alcohols
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Hybrid glycopeptide - Histidine or derivatives - Fatty acyl glycoside - Fatty acyl glycoside of mono- or disaccharide - N-acyl-alpha amino acid or derivatives - Gamma amino acid or derivatives - Alpha-amino acid amide - Disaccharide - Glycosyl compound - Beta amino acid or derivatives - O-glycosyl compound - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Pyrimidine-6-carboxylic acid or derivatives - Thiazolecarboxylic acid or derivatives - 2-heteroaryl carboxamide - Thiazolecarboxamide - Aralkylamine - 2,4-disubstituted 1,3-thiazole - Aminopyrimidine - Fatty amide - Oxane - Fatty acyl - N-acyl-amine - Imidolactam - Pyrimidine - Heteroaromatic compound - Organic sulfuric acid or derivatives - Azole - Carbamic acid ester - Imidazole - Thiazole - Amino acid or derivatives - Secondary carboxylic acid amide - Secondary alcohol - Primary carboxylic acid amide - Carboxamide group - Carbonic acid derivative - Secondary amine - Azacycle - Organoheterocyclic compound - Acetal - Carboxylic acid derivative - Oxacycle - Secondary aliphatic amine - Organic nitrogen compound - Primary aliphatic amine - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Carbonyl group - Primary alcohol - Primary amine - Organic zwitterion - Organic salt - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Alcohol - Organic oxygen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as hybrid glycopeptides. These are compounds containing a carbohydrate component linked to a hybrid peptide component.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water or DMSO
• Sensitivity: Heat & moisture sensitive
• Molecular Weight: 1512.600 g/mol
• Hydrogen Bond Donor Count: 21
• Hydrogen Bond Acceptor Count: 35
• Rotatable Bond Count: 36
• Exact Mass: 1511.48 Da
• Monoisotopic Mass: 1511.48 Da
• Topological Polar Surface Area: 770.000 Ų
• Heavy Atom Count: 101
• Formal Charge: 0
• Complexity: 2660.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 10
• Undefined Atom Stereocenter Count: 9
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

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