Rat anti Human CD44 Antibody, Monoclonal (Hermes-1), could be used for Flow, in vivo CD44 blockade in xenografts, in vitro CD44 blockade, WB, ICC, IF and so on.
Application:
Flow: Use at an assay dependent concentration.
in vivo CD44 blockade in xenografts: Use at an assay dependent concentration.
in vitro CD44 blockade: Use at an assay dependent concentration.
WB: Use at an assay dependent concentration.
ICC/IF: Use at an assay dependent concentration.
Protein Function
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.