D-Lin-MC3-DMA - ≥98% , CAS No.1224606-06-7

CAS: 1224606-06-7 Cat. No.: D302656 Molecular Weight: 642.09

GRADE & PURITY ≥98%

Synonyms

1224606-06-7 | s6683 | AKOS037648583 | SCHEMBL881351 | AB-337/25021010 | dilinoleylmethyl-4-dimethylaminobutyrate | [(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate | HY-112251 | [6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Application

Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Overview

Activity:

Replacement of DSPC by unsaturated PCs and DLin-MC3-DMA by the related lipid DLin-KC2-DMA resulted in highly potent transfection reagents for HeLa cells in vitro.

Specifications

Synonyms

1224606-06-7 | s6683 | AKOS037648583 | SCHEMBL881351 | AB-337/25021010 | dilinoleylmethyl-4-dimethylaminobutyrate | [(6Z, 9Z, 28Z, 31Z)-heptatriaconta-6, 9, 28, 31-tetraen-19-yl] 4-(dimethylamino)butanoate | HY-112251 | [6Z, 9Z, 28Z, 31Z)-heptatriaconta-6, 9, 28, 31-

Specifications & Purity

≥98%

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504770926
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504770926
• Canonical Smiles: CCCCCC=CCC=CCCCCCCCCC(CCCCCCCCC=CCC=CCCCCC)OC(=O)CCCN(C)C
• IUPAC Name: [(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate
• InChIKey: NRLNQCOGCKAESA-KWXKLSQISA-N
• INCHI: 1S/C43H79NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-42(46-43(45)40-37-41-44(3)4)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,42H,5-12,17-18,23-41H2,1-4H3/b15-13-,16-14-,21-19-,22-20-
• Isomeric SMILES: CCCCC/C=C\C/C=C\CCCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC/C=C\C/C=C\CCCCC
• Molecular Weight: 642.09
• Reaxy-Rn: 21997040
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21997040&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Fatty acid esters

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Fatty acid esters
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty acid esters
• Alternative Parents: Trialkylamines Carboxylic acid esters Amino acids and derivatives Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid ester - Amino acid or derivatives - Carboxylic acid ester - Tertiary aliphatic amine - Tertiary amine - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Amine - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Ethanol: 16.67 mg/mL (25.96 mM)；DMSO: 43.33 mg/mL (67.48 mM)
• Sensitivity: Air sensitive；Light sensitive；Heat sensitive
• Boil Point(°C): 670.2±43.0 °C(Predicted)
• Molecular Weight: 642.100 g/mol
• XLogP3: 16.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 36
• Exact Mass: 641.611 Da
• Monoisotopic Mass: 641.611 Da
• Topological Polar Surface Area: 29.500 Ų
• Heavy Atom Count: 46
• Formal Charge: 0
• Complexity: 687.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

References

1. Panpan Xue, Tingjie Bai, Huilan Zhuang, Angelo H. All, Shuangqian Yan, Xuemei Zeng.  (2025)  Cholesterol Metabolism Regulated Nanoliposome Ameliorates Chemo/Photothermal Therapy Reversing CD8+ T Cell Exhaustion.  Exploration,      [PMID:] [10.1002/EXP.20240123]

2. Qiuqun Xiao, Manzhen Zhou, Weihao Qiu, Kailan Liu, Yunrui Hu, Wuye Chen, Fang Liao.  (2025)  Cascade-mediated hepato-escape and targeted co-delivery of LNPs reverse TAM-mediated immunosuppression for immunotherapy and metastasis suppression in cancer.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171849]