Noradrenaline bitartrate monohydrate - PharmPure™, USP, ≥98%(HPLC) , CAS No.108341-18-0

CAS: 108341-18-0 Cat. No.: N107258 Molecular Weight: 337.28 Beilstein Registry Number: 4078502 EC Number: 627-941-5

GRADE & PURITY PharmPure™, USP, ≥98%(HPLC)

Synonyms

Noradrenaline (as tartrate) | (-)-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate | Norepinephrine (Bitartrate) | 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-,(2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt), monohydr

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.
A demethylated precursor of epinephrine.

Specifications

Synonyms

Noradrenaline (as tartrate) | (-)-alpha-(Aminomethyl)-3, 4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate | Norepinephrine (Bitartrate) | 1, 2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-, (2R, 3R)-2, 3-dihydroxybutanedioate (1:1) (salt), monohydr

Specifications & Purity

PharmPure™, USP, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

L-Noradrenaline Bitartrate Monohydrate is a demethylated precursor of epinephrine (adrenaline). It is a sympathomimetic hormone produced by the adrenal gland.Autonomic nervous system neurotransmitter released by sympathetic nerve terminals.

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

PharmPure™, USP

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504762378
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504762378
• Canonical Smiles: C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O
• IUPAC Name: 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;(2R,3R)-2,3-dihydroxybutanedioic acid;hydrate
• InChIKey: LNBCGLZYLJMGKP-LUDZCAPTSA-N
• INCHI: 1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1
• Isomeric SMILES: C1=CC(=C(C=C1[C@H](CN)O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O.O
• WGK Germany: 3
• RTECS: DN6750000
• Alternate CAS: 51-40-1
• Molecular Weight: 337.28
• Beilstein: 4078502
• Reaxy-Rn: 24708504
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24708504&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Phenols
      • Subclass Benzenediols

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Phenols
• Subclass: Benzenediols
• Intermediate Tree Nodes: Not available
• Direct Parent: Catechols
• Alternative Parents: Sugar acids and derivatives Short-chain hydroxy acids and derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Aralkylamines Beta hydroxy acids and derivatives Monosaccharides Fatty acids and conjugates Dicarboxylic acids and derivatives Alpha hydroxy acids and derivatives Benzene and substituted derivatives Secondary alcohols 1,2-aminoalcohols Carboxylic acids Carbonyl compounds Organic oxides Hydrocarbon derivatives Monoalkylamines Aromatic alcohols
• Molecular Framework: Not available
• Substituents: Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Beta-hydroxy acid - Aralkylamine - Sugar acid - Short-chain hydroxy acid - Alpha-hydroxy acid - Monocyclic benzene moiety - Fatty acid - Hydroxy acid - Monosaccharide - Dicarboxylic acid or derivatives - 1,2-aminoalcohol - Secondary alcohol - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Primary aliphatic amine - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic alcohol - Carbonyl group - Hydrocarbon derivative - Organic oxide - Amine - Organic oxygen compound - Alcohol - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as catechols. These are compounds containing a 1,2-benzenediol moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1D Tchem Casein kinase I delta (4546 Activities)

Discover Target: CSNK1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)

Discover Target: S1PR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)

Discover Target: CDK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)

Discover Target: C5AR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)

Discover Target: AURKA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)

Discover Target: CX3CR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FPR2 Tchem Lipoxin A4 receptor (3472 Activities)

Discover Target: FPR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)

Discover Target: FFAR4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

Discover Target: BRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)

Discover Target: GPR35

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)

Discover Target: TRIM24

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BRPF1 Tchem Peregrin (2217 Activities)

Discover Target: BRPF1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Aplnr Apelin receptor (201 Activities)

Discover Target: Aplnr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

Discover Target: Fgfr3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)

Discover Target: Gpr119

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO 64 mg/mL;Water 64 mg/mL;Ethanol <1 mg/mL
• Sensitivity: Light sensitive.
• Specific Rotation[α]: -10.0 to -12.0 deg(C=5, H2O)
• Melt Point(°C): 129 °C
• Molecular Weight: 337.280 g/mol
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 5
• Exact Mass: 337.101 Da
• Monoisotopic Mass: 337.101 Da
• Topological Polar Surface Area: 203.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 276.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Yingying Lei, Khaista Rahman, Xiaojian Cao, Bing Yang, Wei Zhou, Aikebaier Reheman, Luxia Cai, Yifan Wang, Rohit Tyagi, Zhe Wang, Xi Chen, Gang Cao.  (2023)  Epinephrine Stimulates Mycobacterium tuberculosis Growth and Biofilm Formation.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (24): (17370).  [PMID:38139199] [10.3390/ijms242417370]

2. Haiying Shen, Lianhua Dong, Yunhua Gao, Xia Wang, Xinhua Dai.  (2023)  Integrated Microwell Array-Based Microfluidic Chip with a Hand-Held Smartphone-Controlled Device for Nucleic Acid Detection.  ANALYTICAL CHEMISTRY,      [PMID:37787984] [10.1021/acs.analchem.3c03525]

3. Yong Liu, Mingzhu Yang, Juanjuan Li, Wei Zhang, Xingyu Jiang.  (2019)  Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging.  ANALYTICAL CHEMISTRY,      [PMID:31006238] [10.1021/acs.analchem.9b00837]

4. Xia Zhou, Miao Qin, Jun Zhu, Cong Wang, Guang Zhu, Hongyan Wang, Liangbao Yang.  (2018)  Rapid and sensitive surface-enhanced resonance Raman spectroscopy detection for norepinephrine in biofluids.  JOURNAL OF RAMAN SPECTROSCOPY,  50  (3): (314-321).  [PMID:] [10.1002/jrs.5519]

5. Xiaomin Cao, Miao Qin, Pan Li, Binbin Zhou, Xianghu Tang, Meihong Ge, Liangbao Yang, Jinhuai Liu.  (2018)  Probing catecholamine neurotransmitters based on iron-coordination surface-enhanced resonance Raman spectroscopy label.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2018.04.117]

6. Haiying Shen, Feng Qu, Yong Xia, Xingyu Jiang.  (2018)  Straightforward and Ultrastable Surface Modification of Microfluidic Chips with Norepinephrine Bitartrate Improves Performance in Immunoassays.  ANALYTICAL CHEMISTRY,      [PMID:29478312] [10.1021/acs.analchem.7b05186]

7. Shanying Han, Tianyu Du, Hui Jiang, Xuemei Wang.  (2016)  Synergistic effect of pyrroloquinoline quinone and graphene nano-interface for facile fabrication of sensitive NADH biosensor.  BIOSENSORS & BIOELECTRONICS,      [PMID:27156055] [10.1016/j.bios.2016.04.092]

8. Meizhu Wu, Yuting Zhou, Zhi Guo, Dawei Lian, Hong Chen, Renfeng Li, Jing Lin, Farman Ali, Aling Shen, Jun Peng.  (2025)  Isoliensinine promotes vasorelaxation and inhibits constriction by regulating the calcium channel in hypertension: In vitro and in vivo approaches.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:40414594] [10.1016/j.ejphar.2025.177765]