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· · COA & SDS available for every product · Same-day shipping on in-stock items NPS 2143 hydrochloride - ≥99% , CAS No.324523-20-8
Synonyms
HY-10171 | 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride | NPS-2143 HCL | J-018742 | NPS 2143 hydrochloride | NPS-2143hydrochloride | A846766 | 2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHAL
Storage
Room temperature,Desiccated
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Why this grade ≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Room temperature,Desiccated Ships Normal Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Specifications Synonyms
HY-10171 | 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride | NPS-2143 HCL | J-018742 | NPS 2143 hydrochloride | NPS-2143hydrochloride | A846766 | 2-CHLORO-6-[(2R)-3-[[1, 1-DIMETHYL-2-(2-NAPHTHAL
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
Potent, selective Ca 2+ -sensing receptor antagonist (IC 50 = 43 nM). Stimulates parathyroid hormone secretion (EC 50 = 41 nM). Shows antihypertensive effects in vivo. Orally active.
Storage
Room temperature, Desiccated
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Names and Identifiers Canonical Smiles CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O.Cl IUPAC Name 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride InChIKey ZEBNDUQLNGYBNL-VEIFNGETSA-N INCHI 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1 Isomeric SMILES CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl Molecular Weight 445.39 Reaxy-Rn 23817517 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23817517&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Naphthalenes Subclass Not available Intermediate Tree Nodes Not available Direct Parent Naphthalenes Alternative Parents Phenoxy compounds Phenol ethers Benzonitriles Chlorobenzenes Aralkylamines Alkyl aryl ethers Aryl chlorides Secondary alcohols 1,2-aminoalcohols Nitriles Dialkylamines Organopnictogen compounds Organochlorides Hydrochlorides Hydrocarbon derivatives Molecular Framework Aromatic homopolycyclic compounds Substituents Naphthalene - Phenoxy compound - Benzonitrile - Phenol ether - Alkyl aryl ether - Aralkylamine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - 1,2-aminoalcohol - Secondary alcohol - Secondary amine - Secondary aliphatic amine - Ether - Carbonitrile - Nitrile - Organic oxygen compound - Alcohol - Organooxygen compound - Organic nitrogen compound - Hydrochloride - Hydrocarbon derivative - Organopnictogen compound - Organonitrogen compound - Organochloride - Amine - Organohalogen compound - Aromatic homopolycyclic compound Description This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Soluble in ethanol to 10 mM and in DMSO to 100 mM Molecular Weight 445.400 g/mol XLogP3 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4 Rotatable Bond Count 8 Exact Mass 444.137 Da Monoisotopic Mass 444.137 Da Topological Polar Surface Area 65.300 Ų Heavy Atom Count 30 Formal Charge 0 Complexity 560.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 2
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