CSNK2A2 Antibody - Primary antibody, specific to CSNK2A2, Rabbit IgG

Cat. No.: Ab097973

GRADE & PURITY Validated, 1.0 mg/mL

Application

WB

Host species

Rabbit

Reactive species

Human, Mouse, Rat

Isotype

Rabbit IgG

Conjugation

Unconjugated

Descripción general

Rabbit anti Human CSNK2A2 Antibody, Polyclonal, could be used for WB and so on.
Application
WB: 1/500-1/2000
Protein Function
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Specifications

Product Name

CSNK2A2 Antibody - Primary antibody, specific to CSNK2A2, Rabbit IgG

Sinónimos

Casein kinase 2 alpha prime polypeptide | Casein kinase II alpha' chain | Casein kinase II subunit alpha' | CK II alpha' | CK II | CK2A2 | CKII | CSK22_HUMAN | CSNK2A1 | CSNK2A2 | FLJ43934 | Casein kinase 2 alpha prime polypeptide antibody | Casein kinase

Especificaciones y pureza

Validated, 1.0 mg/mL

Especies hospedadoras

Rabbit

Especificidad

CSNK2A2

Inmunógeno

Synthesized peptide derived from part region of human protein

Control positivo

WB: K562, HeLa, HUVEC, Jurkat, NIH/3T3 and C6 cell lysates.

Conjugación

Unconjugated

Grado

Validated

Isotipo

Rabbit IgG

SDS-PAGE

150 kDa

Método de purificación

Immunogen affinity purified

Concentración

1.0 mg/mL

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

Store at 4°C short term (1-2 weeks). Store at -20℃ long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Western Blot: CSNK2A2 Antibody (Ab097973)

CSNK2A2 Antibody (Ab097973) - Western Blot
All lanes: CSNK2A2 Antibody (Ab097973) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) at 1/20000 dilution

Predicted band size: 41 kDa
Observed band size: 35 kDa
Exposure time: 50.0 s

Aplicación

• Aplicación: Dilution info
• WB:

  1/500-1/2000;

Objetivos asociados (humanos)

CSNK2A2 Tchem Casein kinase II subunit alpha' (0 Activities)

Discover Target: CSNK2A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción