Frexalimab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1

CAS: 2515463-86-0 Cat. No.: Ab182964

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Human

Isotype

Human IgG1

Conjugation

Unconjugated

Descripción general

Frexalimab (anti-CD40L) is a monoclonal antibody targeting the CD40 ligand (CD40L). Frexalimab (anti-CD40L) has the potential for multiple sclerosis research.

Specifications

Product Name

Frexalimab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1

Sinónimos

HIGM1 | T-B cell-activating molecule | T-BAM | T-cell antigen Gp39 | TNF-related activation protein | TNFSF5 | TNFSF5IMD3 | TRAP | TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) | tumor necrosis factor (ligand) superfamily m

Especificaciones y pureza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Mecanismos bioquímicos y fisiológicos

Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization,

Especies hospedadoras

Human

Especificidad

CD40LG

Conjugación

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo de acción

INHIBITOR

Isotipo

Human IgG1

Tipo de cadena ligera

kappa

SDS-PAGE

145.66 kDa

Método de purificación

Protein A purified

Concentración

See COA

CAS

2515463-86-0

Almacenamiento y envío

Condiciones de almacenamiento de almacenamiento

Store at -80°C,Avoid repeated freezing and thawing

Enviado en

Dry ice packs + Cold packs

Estabilidad y almacenamiento

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Flow Cytometry: Frexalimab (anti-CD40L) (Ab182964)

Frexalimab (anti-CD40L) (Ab182964) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling CD40L (red) with Frexalimab (anti-CD40L) (Ab182964) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Frexalimab (anti-CD40L) (Ab182964)

Frexalimab (anti-CD40L) (Ab182964) - SEC
The purity of Frexalimab (anti-CD40L) (Ab182964) is more than 95% verified by HPLC.

ELISA: Frexalimab (anti-CD40L) (Ab182964)

Frexalimab (anti-CD40L) (Ab182964) - ELISA
Immobilized Recombinant Human CD40 Ligand/TNFSF5 protein (rp189423) at 1.0 μg/mL can bind Frexalimab (anti-CD40L) (Ab182964) with the EC ₅₀  of 16.93 ng/mL.

Objetivos asociados (humanos)

CD40LG Tbio CD40 ligand (0 Activities)

Discover Target: CD40LG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción