Recombinant Elav-type RNA-binding protein ETR3 Antibody - Primary antibody, specific to CELF2, Rabbit IgG

Cat. No.: Ab101483

GRADE & PURITY Recombinant, Validated, ExactAb™, 1.5 mg/mL

Application

WB

Host species

Rabbit

Reactive species

Human, Mouse, Rat

Isotype

Rabbit IgG

Conjugation

Unconjugated

Descripción general

Rabbit anti Human Elav-type RNA-binding protein ETR3 Antibody, Recombinant, could be used for WB and so on.

Application:

WB: 1/2000

Protein Function：

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats.

Specifications

Product Name

Recombinant Elav-type RNA-binding protein ETR3 Antibody - Primary antibody, specific to CELF2, Rabbit IgG

Sinónimos

CELF2 | ETR3 | DEE97 | ETR-3 | NAPOR | CELF-2 | CUGBP2 | BRUNOL3 | CUG-BP2 | Bruno-like protein 3 antibody | BRUNOL3 antibody | Cardiac elav type RNA binding protein antibody | CELF-2 antibody | celf2 antibody | CELF2_HUMAN antibody | CUG BP2 antibody | C

Especificaciones y pureza

ExactAb™, Validated, Recombinant, 1.5 mg/mL

Especies hospedadoras

Rabbit

Especificidad

CELF2

Inmunógeno

Recombinant protein of human CELF-2 (AA 408-508)

Control positivo

WB: HEK293, HeLa, K562, Hep G2, NIH/3T3 and C6 cell lysates.

Conjugación

Unconjugated

Grado

ExactAb™, Recombinant, Validated

Isotipo

Rabbit IgG

Tipo de cadena ligera

kappa

SDS-PAGE

150 kDa

Método de purificación

Protein A purified

Concentración

1.5 mg/mL

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Western Blot: Recombinant Elav-type RNA-binding protein ETR3 Antibody (Ab101483)

Recombinant Elav-type RNA-binding protein ETR3 Antibody (Ab101483) - Western Blot
All lanes: Recombinant Elav-type RNA-binding protein ETR3 Antibody (Ab101483) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 54 kDa
Observed band size: 52, 54 kDa
Exposure time: 6.2 s

Aplicación

• Aplicación: Dilution info
• WB:

  1/2000;

Objetivos asociados (humanos)

CELF2 Tbio CUGBP Elav-like family member 2 (0 Activities)

Discover Target: CELF2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)