Recombinant ErbB4/HER4 Antibody - Primary antibody, specific to ERBB4, Rabbit IgG

Cat. No.: Ab102129

GRADE & PURITY Recombinant, Validated, ExactAb™, See COA

Application

WB

Host species

Rabbit

Reactive species

Human, Mouse, Rat

Isotype

Rabbit IgG

Conjugation

Unconjugated

Descripción general

Rabbit anti Human ErbB4/HER4 Antibody, Recombinant, could be used for WB and so on.

Application:

· WB: 1/500-1/2000

Protein Function

Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. The C-terminal fragment (CTF) of isoform JMA-A CYT-2 (containing E4ICD2) can stimulate transcription in the presence of YAP1. ERBB4 intracellular domain is involved in the regulation of cell growth. Conflicting reports are likely due at least in part to the opposing effects of the isoform-specific and nuclear-translocated ERBB4 intracellular domains (E4ICD1 and E4ICD2). Overexpression studies in epithelium show growth inhibition using E4ICD1 and increased proliferation using E4ICD2. E4ICD2 has greater in vitro kinase activity than E4ICD1. The kinase activity is required for the nuclear translocation of E4ICD2.

Specifications

Product Name

Recombinant ErbB4/HER4 Antibody - Primary antibody, specific to ERBB4, Rabbit IgG

Sinónimos

p180erbB4 | ALS19 | HER4 | VERBB2 antibody | Verba erythroblastic leukemia viral oncogene homolog 4 antibody | Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody | V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 ant

Especificaciones y pureza

Recombinant, ExactAb™, Validated, See COA

Especies hospedadoras

Rabbit

Especificidad

ERBB4

Inmunógeno

A synthetic peptide derived from human ErbB4 (AA 1240-1270).

Control positivo

WB: Mouse brain and Rat brain lysates.

Conjugación

Unconjugated

Grado

ExactAb™, Recombinant, Validated

Isotipo

Rabbit IgG

Tipo de cadena ligera

kappa

SDS-PAGE

150 kDa

Método de purificación

Protein A purified

Concentración

See COA

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Western Blot: Recombinant ErbB4/HER4 Antibody (Ab102129)

Recombinant ErbB4/HER4 Antibody (Ab102129) - Western Blot
All lanes: Recombinant ErbB4/HER4 Antibody (Ab102129) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 185 kDa
Observed band size: 176 kDa
Exposure time: 106.0 s

Aplicación

• Aplicación: Dilution info
• WB:

  1/500-1/2000 ;

Objetivos asociados (humanos)

ERBB4 Tclin Receptor tyrosine-protein kinase erbB-4 (0 Activities)

Discover Target: ERBB4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción