Recombinant RAGE Antibody - Primary antibody, specific to RAGE, Rabbit IgG

Cat. No.: Ab124452

GRADE & PURITY Recombinant, Validated, ExactAb™, See COA

Application

WB

Host species

Rabbit

Reactive species

Human, Mouse, Rat

Isotype

Rabbit IgG

Conjugation

Unconjugated

Descripción general

Rabbit anti Human RAGE Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500-1/2000
Protein Function：
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.

Specifications

Product Name

Recombinant RAGE Antibody - Primary antibody, specific to RAGE, Rabbit IgG

Sinónimos

Ager antibody | DAMA 358M23.4 antibody | MGC2235 antibody | MGC22357 antibody | RAGE_HUMAN antibody | Receptor for advanced glycation end products antibody | Receptor for advanced glycosylation end products antibody | advanced glycosylation end product-sp

Especificaciones y pureza

Recombinant, ExactAb™, Validated, See COA

Especies hospedadoras

Rabbit

Especificidad

RAGE

Inmunógeno

A synthetic peptide derived from human RAGE (AA 344-404).

Control positivo

WB: Mouse lung and Rat lung lysates.

Conjugación

Unconjugated

Grado

ExactAb™, Recombinant, Validated

Isotipo

Rabbit IgG

Tipo de cadena ligera

kappa

SDS-PAGE

150 kDa

Método de purificación

Protein A purifie

Concentración

See COA

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

WB: Mouse lung lysates.

Imágenes

Western Blot: Recombinant RAGE Antibody (Ab124452)

Recombinant RAGE Antibody (Ab124452) - Western Blot
All lanes: Recombinant RAGE Antibody (Ab124452) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 43 kDa
Observed band size: 48 kDa
Exposure time: 25.9 s

Aplicación

• Aplicación: Dilution info
• WB:

  1/500-1/2000;

Objetivos asociados (humanos)

AGER Tchem Advanced glycosylation end product-specific receptor (0 Activities)

Discover Target: AGER

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción