MEK Inhibitor I - Moligand™, ≥95% , Inhibitor of mitogen-activated protein kinase kinase 1;Inhibitor of mitogen-activated protein kinase kinase 3;Inhibitor of mitogen-activated protein kinase kinase 4, CAS No.297744-42-4, Inhibitor of mitogen-activated protein kinase kinase 1;Inhibitor of mitogen-activated protein kinase kinase 3;Inhibitor of mitogen-activated protein kinase kinase 4

CAS: 297744-42-4 Cat. No.: M338480 Molecular Weight: 374.46

GRADE & PURITY Moligand™, ≥95%

Synonyms

MEK-IN-4

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

MEK Inhibitor I is a cell-permeable, pyridine-containing, vinylogous cyanamide that has the ability to act as a selective and potent inhibitor of MEK with little activity towards MKK3 and MKK4. The compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP) and the demonstrated inhibition is noncompetitive with respect to ERK. Compared to U0126 in aqueous solutionsMEK Inhibitor I demonstrates superior potency, solubility, and stability. Additionally shown to protect against phorbol ester-mediated ear edema in mice.

Specifications

Synonyms

MEK-IN-4

Specifications & Purity

Moligand™, ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of mitogen-activated protein kinase kinase 1;Inhibitor of mitogen-activated protein kinase kinase 3;Inhibitor of mitogen-activated protein kinase kinase 4

Purity

≥95%

Names and Identifiers

• Canonical Smiles: C1=CC=C(C(=C1)N)SC(=C(C#N)C2=CC=CC(=C2)C(C3=CC=NC=C3)O)N
• IUPAC Name: (E)-3-amino-3-(2-aminophenyl)sulfanyl-2-[3-[hydroxy(pyridin-4-yl)methyl]phenyl]prop-2-enenitrile
• InChIKey: NHBMKTBZZSJUGA-FXBPSFAMSA-N
• INCHI: 1S/C21H18N4OS/c22-13-17(21(24)27-19-7-2-1-6-18(19)23)15-4-3-5-16(12-15)20(26)14-8-10-25-11-9-14/h1-12,20,26H,23-24H2/b21-17-
• Isomeric SMILES: C1=CC=C(C(=C1)N)S/C(=C(/C#N)\C2=CC=CC(=C2)C(C3=CC=NC=C3)O)/N
• Molecular Weight: 374.46
• Reaxy-Rn: 36266949
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36266949&ln=

Associated Targets(Human)

MAP2K3 Tchem Dual specificity mitogen-activated protein kinase kinase 3 (1 Activities)

Discover Target: MAP2K3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K4 Tchem Dual specificity mitogen-activated protein kinase kinase 4 (1 Activities)

Discover Target: MAP2K4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 (1 Activities)

Discover Target: MAP2K1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: DMSO and methanol