Experiments on the preparation of dispersions
Experiments on the preparation of dispersions
Dispersions are dry powdery preparations of drugs or with suitable excipients made by crushing and uniform mixing for internal or topical use. Internal dispersions are usually dissolved or dispersed in water or other liquids, and can also be taken directly with water. Topical dispersions can be applied to the skin, mouth, throat, cavity, etc.; specifically for the purpose of treatment, prevention and lubrication of the skin for the purpose of the dispersions can also be referred to as spreading agent or spreading powder.
Operation method
illustrative method
Materials and Instruments
Sodium bicarbonate Magnesium oxide Move I. Preparation Caveat 1. This product can be used alternately with Xipisan II to correct the shortcomings of diarrhea caused by magnesium oxide, and can also be taken alone according to the condition. 2. Magnesium oxide can absorb carbon dioxide and water in the air, forming magnesium carbonate and reducing the power of acid production, so it should be stored against moisture. For more product details, please visit Aladdin Scientific website.
Sodium bisulfate
mortar, sieve, balance
1. Weighing: the correct choice of balance and the method of weighing medicines in various states of agglomeration.
2. Crush: is the preparation of bulk and related dosage forms of the basic operation. Require students according to the physical and chemical properties of drugs, the use of requirements, reasonable choice of crushing tools and methods.
3. Sieving: master the basic method, clear sieving operation should pay attention to the problem.
4. Mixing: the homogeneity of mixing is an important indicator of the quality of the dispersions, especially the dispersions containing a small amount of toxic drugs for medical use and valuable drugs, in order to ensure the homogeneity of mixing, the method of equalizing and adding should be adopted (the method of matching and research). For the dispersions containing a small amount of volatile oil and eutectic ingredients, other ingredients in the prescription can be absorbed and then mixed with other ingredients.
5. Packaging: Learn how to package the bulk packets in divided doses in five-cornered packets, four-cornered packets, rectangular packets, and so on.
6. Quality checks: conducted in accordance with the provisions of the Pharmacopoeia.
II. Specific operations
Sodium bicarbonate and magnesium oxide were studied fine sieve, sodium bisulfate added to magnesium oxide, research and integration of uniform, divided into 100 packages, each package of 1.2 g that is obtained.