Fmoc chloride - for HPLC derivatization, ≥99%(HPLC) , CAS No.28920-43-6

CAS: 28920-43-6 Cat. No.: F106534 Molecular Weight: 258.7 Beilstein Registry Number: 2279177 EC Number: 249-313-6

GRADE & PURITY for HPLC derivatization, ≥99%(HPLC)

Synonyms

Fmoc-Cl | (9H-Fluoren-9-ylmethoxy)carbonyl Chloride | 9-Fluorenylmethoxycarbonyl chloride | 9-Fluorenylmethyl chloroformate | Chloroformic Acid 9-Fluorenylmethyl Ester

Storage

Store at 2-8°C,Argon charged,Desiccated

Shipped In

Wet ice

Overview

Amino acid derivatizing agent for HLPC analysis. N-protecting reagent for peptide and oligonucleotide syntheses. Reagent for amino group protection recently used in the synthesis of a bicyclic proline analog. Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis.

Specifications

Synonyms

Fmoc-Cl | (9H-Fluoren-9-ylmethoxy)carbonyl Chloride | 9-Fluorenylmethoxycarbonyl chloride | 9-Fluorenylmethyl chloroformate | Chloroformic Acid 9-Fluorenylmethyl Ester

Specifications & Purity

for HPLC derivatization, ≥99%(HPLC)

Storage

Store at 2-8°C, Argon charged, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

for HPLC derivatization

Purity

≥99%(HPLC)

Names and Identifiers

• Canonical Smiles: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl
• IUPAC Name: 9H-fluoren-9-ylmethyl carbonochloridate
• InChIKey: IRXSLJNXXZKURP-UHFFFAOYSA-N
• INCHI: 1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
• Isomeric SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl
• WGK Germany: 3
• RTECS: LQ6250000
• UN Number: 3261
• Molecular Weight: 258.7
• Beilstein: 2279177
• Reaxy-Rn: 2279177
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2279177&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Organic carbonic acids and derivatives Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Fluorene - Carbonic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organochloride - Organohalogen compound - Carbonyl group - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Moisture sensitive;Heat sensitive
• Melt Point(°C): 61.0 - 65.0 °C
• Molecular Weight: 258.700 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 258.045 Da
• Monoisotopic Mass: 258.045 Da
• Topological Polar Surface Area: 26.300 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 296.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

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