Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Suberoylanilide Hydroxamic Acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor that has been shown to inhibit proliferation and cause cell cycle arrest at G1. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin.
A potent HDAC inhibitor; also causes cell cycle arrest at G1
SAHA may be used to study gene regulation, transcription regulation and cell signaling.
| ALogP | 1.9 |
|---|
| Pubchem Sid | 488179890 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179890 |
| Canonical Smiles | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
| IUPAC Name | N'-hydroxy-N-phenyloctanediamide |
| InChIKey | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| INCHI | 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) |
| Isomeric SMILES | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
| WGK Germany | 3 |
| PubChem CID | 5311 |
| Molecular Weight | 264.32 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzene and substituted derivatives |
| Alternative Parents | Propargyl-type 1,3-dipolar organic compounds Carboximidic acids Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Monocyclic benzene moiety - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidic acid derivative - Carboximidic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. |
| External Descriptors | dicarboxylic acid diamide - hydroxamic acid |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 28, 2026 | V125336 | |
| Certificate of Analysis | Jan 05, 2026 | V125336 | |
| Certificate of Analysis | Nov 23, 2024 | V125336 | |
| Certificate of Analysis | Oct 23, 2024 | V125336 | |
| Certificate of Analysis | Oct 23, 2024 | V125336 | |
| Certificate of Analysis | Oct 23, 2024 | V125336 | |
| Certificate of Analysis | Oct 23, 2024 | V125336 | |
| Certificate of Analysis | Oct 23, 2024 | V125336 | |
| Certificate of Analysis | Oct 11, 2024 | V125336 | |
| Certificate of Analysis | Oct 11, 2024 | V125336 | |
| Certificate of Analysis | Oct 11, 2024 | V125336 | |
| Certificate of Analysis | Oct 11, 2024 | V125336 | |
| Certificate of Analysis | Oct 11, 2024 | V125336 | |
| Certificate of Analysis | May 12, 2023 | V125336 | |
| Certificate of Analysis | May 12, 2023 | V125336 | |
| Certificate of Analysis | May 12, 2023 | V125336 | |
| Certificate of Analysis | May 06, 2022 | V125336 | |
| Certificate of Analysis | Jun 07, 2021 | V125336 |
| Solubility | Soluble in ethanol (3 mg/ml at 25 °C), DMSO (53 mg/ml at 25 °C), DMF (~20 mg/ml), water (1.17 mg/ml at 25 °C), and methanol. |
|---|---|
| Sensitivity | Heat sensitive |
| Melt Point(°C) | 155 °C |
| Molecular Weight | 264.320 g/mol |
| XLogP3 | 1.900 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 8 |
| Exact Mass | 264.147 Da |
| Monoisotopic Mass | 264.147 Da |
| Topological Polar Surface Area | 78.400 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 276.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Penghui Du, Wen Liu, Qiang Zhang, Peng Zhang, Chen He, Quan Shi, Ching-Hua Huang, Junjian Wang. (2023) Transformation of dissolved organic matter during UV/peracetic acid treatment. WATER RESEARCH, [PMID:36738558] [10.1016/j.watres.2023.119676] |
| 2. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). [PMID:35743042] [10.3390/ijms23126597] |
| 3. Yue Wei, Si Wu, Zhenqi Liu, Jingsheng Niu, Ya Zhou, Jinsong Ren, Xiaogang Qu. (2022) Tumor associated macrophages reprogrammed by targeted bifunctional bioorthogonal nanozymes for enhanced tumor immunotherapy. Materials Today, [PMID:] [10.1016/j.mattod.2022.01.024] |
| 4. Rui Li, Li Xie, Lei Li, Xiaojiao Chen, Tong Yao, Yuanxin Tian, Qingping Li, Kai Wang, Chenyang Huang, Cui Li, Yifan Li, Hongwei Zhou, Neil Kaplowitz, Yong Jiang, Peng Chen. (2021) The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice. Acta Pharmaceutica Sinica B, [PMID:35127379] [10.1016/j.apsb.2021.05.029] |
| 5. Pisano S., Wang X., Garcia-Parra J., Gazze A., Edwards K., Feltracco V., Hu Y., He L., Gonzalez D., Francis L. W., Conlan R. S., Li C.. (2020) Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro. Cancer Nanotechnology, 11 (1): (1-17). [PMID:] [10.1186/s12645-020-00070-8] |
| 6. Xie Qiu-shi, Zhang Jia-xin, Liu Ming, Liu Pei-hua, Wang Zhong-jian, Zhu Liang, Jiang Ling, Jin Meng-meng, Liu Xiao-nan, Liu Li, Liu Xiao-dong. (2020) Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine. ACTA PHARMACOLOGICA SINICA, 42 (3): (470-481). [PMID:32555444] [10.1038/s41401-020-0402-x] |
| 7. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] [10.1039/C7RA10376J] |
| 8. Dong Shanshan, Li Mu, Chen Yinguang. (2017) Inherent humic substance promotes microbial denitrification of landfill leachate via shifting bacterial community, improving enzyme activity and up-regulating gene. Scientific Reports, 7 (1): (1-10). [PMID:28939832] [10.1038/s41598-017-12565-3] |
| 9. Xiao-Li Zheng, Zhi-Di Li, Kai-Zhi Luo, Yang-Ling Li, Ye-Han Liu, Shu-Ying Shen, Fei-Yan Shen, Wan-Yan Li, Guo-Qing Chen, Chong Zhang, Ling-Hui Zeng. (2024) POLR2J expression promotes glioblastoma malignancy by regulating oxidative stress and the STAT3 signaling pathway. American Journal of Cancer Research, [PMID:38859843] [10.62347/JEWM7691] |
| 10. Lu Hui, Fu Wenying, Xia Yiqun, Yan Ying, Shu Chongchong, Chen Yinghua, Xu Chenxin, Zheng Peisen, Shen Xin, Cui Ri, Zou Peng, Ni Daoyong. (2025) Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer. Cell Death Discovery, 11 (1): (1-16). [PMID:40750601] [10.1038/s41420-025-02657-9] |
| 11. Lei Hou, Yunchang Zhang, Ying Huang, Zhen Fang, Guangze Sang, Tianheng Chen, Zhiqiang Ma, Feng Yang. (2022) Coupling Chlorin-Based Photosensitizers and Histone Deacetylase Inhibitors for Photodynamic Chemotherapy. MOLECULAR PHARMACEUTICS, [PMID:35758904] [10.1021/acs.molpharmaceut.2c00170] |
| 12. Jia Man, Xiaojie Wang, Jianyong Li, Xiaoyang Cui, Zesheng Hua, Jianfeng Li, Zebing Mao, Shanguo Zhang. (2022) Intravenous Calcium Alginate Microspheres as Drug Delivery Vehicles in Acute Kidney Injury Treatment. Micromachines, 13 (4): (538). [PMID:35457843] [10.3390/mi13040538] |
| 13. Yingjie Yu, Bingkai Wang, Miao Sun, Yunchang Zhang, Lei Hou, Sizhen Wang, Tianheng Chen, Feng Yang, Zhiqiang Ma. (2022) Lysosomal activable Vorinostat carrier-prodrug self-assembling with BPQDs enables photothermal oncotherapy to reverse tumor thermotolerance and metastasis. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:35202725] [10.1016/j.ijpharm.2022.121580] |
| 14. Miao Jiefei, Meng Chi, Wu Hongmei, Shan Wenpei, Wang Haoran, Ling Changchun, Zhang Jinlin, Yang Tao. (2021) Novel Hybrid CHC from β-carboline and N-Hydroxyacrylamide Overcomes Drug-Resistant Hepatocellular Carcinoma by Promoting Apoptosis, DNA Damage, and Cell Cycle Arrest. Frontiers in Pharmacology, [PMID:33536926] [10.3389/fphar.2020.626065] |
| 15. Shanguo Zhang, Xiaojie Wang, Jia Man, Jianyong Li, Xiaoyang Cui, Chuanwei Zhang, Weichen Shi, Donghai Li, Song Zhang, Jianfeng Li. (2020) Histone Deacetylase Inhibitor-loaded Calcium Alginate Microspheres for Acute Kidney Injury Treatment. ACS Applied Bio Materials, [PMID:35021777] [10.1021/acsabm.0c00874] |
| 16. Qian Zhu, Lixin Jia, Zhongfei Gao, Chunming Wang, Haoyang Jiang, Junfeng Zhang, Lei Dong. (2014) A Tumor Environment Responsive Doxorubicin-Loaded Nanoparticle for Targeted Cancer Therapy. MOLECULAR PHARMACEUTICS, [PMID:24735448] [10.1021/mp4007776] |
| 17. Weiwei Jiang, Yuwei Cheng, Lei Hou, Ying Huang, Sizhen Wang, Yunchang Zhang, Tao Jiang, Feng Yang, Zhiqiang Ma. (2024) A dual-prodrug nanogel combining Vorinostat and Pyropheophorbide a for a high efficient photochemotherapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:38977163] [10.1016/j.ijpharm.2024.124422] |
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