≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
Product description
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.
Potent, small molecule Bcl-2 family protein inhibitor (Ki’s of <1 nM for Bcl-2, Bcl-XL and Bcl-w). Orally bioavailable. Displays anticancer properties. Selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and disrupts Bcl-2/Bcl-XL i
Storage
Store at -20°C, Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Yun Zhou, Ke Li, Fan Li, Shuang Han, Yang Wang, Xueping Li, Yonghua Zhan. (2019) Doxorubicin and ABT-199 Coencapsulated Nanocarriers for Targeted Delivery and Synergistic Treatment against Hepatocellular Carcinoma. Journal of Nanomaterials, [PMID:][10.1155/2019/5274598]
2.Ming Zhang, Yamei Wang, Yao Dai, Yan Hu, Wanting Fu, Yuhao Zhao, Hanyu Ma, Di Zhang, Ying Chen, Yixuan Zhou, Lei Du, Jing Chang, Fang Liu, Shuyan Chen, Fei Wang, Dongdong Xiao, Zhen Li. (2025) Senolytic-Loaded Asymmetric Wound Dressing for Targeted Senescent Cell Clearance in Diabetic Wound Healing. Materials Today Bio, [PMID:41560809][10.1016/j.mtbio.2025.102741]
3.Jing Zhang, Xinghua Li, Ping Wang, Xin Liu, Wuqi Guo, Jia Si, Qiang Huo, Ming Xu, Yang Liu, Yimin Niu. (2026) Disrupting the Senescence-Associated Secretory Phenotype–M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis. ACS Nano, [PMID:41636104][10.1021/acsnano.5c15543]
Solution Calculators
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Dilution Calculator
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C2325096