E-3810 - Moligand™, ≥98% , Fibroblast growth factor receptor 2 inhibitor, CAS No.1058137-23-7, Fibroblast growth factor receptor 2 inhibitor

CAS: 1058137-23-7 Cat. No.: E127640 Molecular Weight: 443.49
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
1,13-dimethyl-10-(3-methyl-2-butenyl)-(1R,9R,13R)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol(Pentazocine) | LUCITANIB [WHO-DD] | Pentobarbitone (VAN) | 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-N-methyl-1-naphthamide | AMY
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
E127640-1mg
3

$69.90

$104.90
Save $35.00 (33.37%)
5mg
E127640-5mg
3

$89.90

$134.90
Save $45.00 (33.36%)
10mg
E127640-10mg
2

$116.90

$175.90
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25mg
E127640-25mg
2

$151.90

$227.90
Save $76.00 (33.35%)
50mg
E127640-50mg
2

$256.90

$385.90
Save $129.00 (33.43%)
100mg
E127640-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

$436.90

$655.90
Save $219.00 (33.39%)
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
1, 13-dimethyl-10-(3-methyl-2-butenyl)-(1R, 9R, 13R)-10-azatricyclo[7.3.1.02, 7]trideca-2(7), 3, 5-trien-4-ol(Pentazocine) | LUCITANIB [WHO-DD] | Pentobarbitone (VAN) | 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-N-methyl-1-naphthamide | AMY
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms

E-3810, a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2

Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Fibroblast growth factor receptor 2 inhibitor
Purity
≥98%
Product Properties
ALogP3.6
Names and Identifiers
Pubchem Sid504769941
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504769941
Canonical SmilesCNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
IUPAC Name6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide
InChIKeyCUDVHEFYRIWYQD-UHFFFAOYSA-N
INCHI1S/C26H25N3O4/c1-28-25(30)19-5-3-4-16-12-17(6-7-18(16)19)33-22-8-11-29-21-14-24(23(31-2)13-20(21)22)32-15-26(27)9-10-26/h3-8,11-14H,9-10,15,27H2,1-2H3,(H,28,30)
Isomeric SMILES CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
Molecular Weight 443.49
Reaxy-Rn 18478470
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18478470&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassNaphthalenes
SubclassNaphthalenecarboxylic acids and derivatives
Intermediate Tree Nodes Not available
Direct ParentNaphthalenecarboxamides
Alternative Parents Diarylethers  Quinolines and derivatives  Anisoles  Alkyl aryl ethers  Pyridines and derivatives  Heteroaromatic compounds  Secondary carboxylic acid amides  Amino acids and derivatives  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 1-naphthalenecarboxamide - Diaryl ether - Quinoline - Anisole - Alkyl aryl ether - Pyridine - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Ether - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Primary aliphatic amine - Amine - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Organonitrogen compound - Organooxygen compound - Primary amine - Organopnictogen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as naphthalenecarboxamides. These are compounds containing a naphthalene moiety, which bears a carboxylic acid amide group at one or more positions. Naphthalene is a bicyclic compound that is made up of two fused benzene rings.
External Descriptors aromatic ether - quinolines - primary amino compound - cyclopropanes - naphthalenecarboxamide
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
DDR1 Tchem Epithelial discoidin domain-containing receptor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RET Tclin Proto-oncogene tyrosine-protein kinase receptor Ret (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT4 Tclin Vascular endothelial growth factor receptor 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGFR1 Tclin Fibroblast growth factor receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDGFRA Tclin Platelet-derived growth factor receptor alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDGFRB Tclin Platelet-derived growth factor receptor beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT1 Tclin Vascular endothelial growth factor receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDR Tclin Vascular endothelial growth factor receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KIT Tclin Mast/stem cell growth factor receptor Kit (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
B2603038Certificate of AnalysisFeb 25, 2026 E127640
L2117112Certificate of AnalysisJul 15, 2025 E127640
L2117113Certificate of AnalysisJul 15, 2025 E127640
L2117128Certificate of AnalysisJul 15, 2025 E127640
L2117319Certificate of AnalysisJul 15, 2025 E127640
L2117320Certificate of AnalysisJul 15, 2025 E127640
L2117321Certificate of AnalysisJul 15, 2025 E127640
L2420505Certificate of AnalysisJan 03, 2025 E127640
Chemical and Physical Properties
SolubilityDMSO
Molecular Weight443.500 g/mol
XLogP33.600
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass443.185 Da
Monoisotopic Mass443.185 Da
Topological Polar Surface Area95.700 Ų
Heavy Atom Count33
Formal Charge0
Complexity686.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

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