Guanidine thiocyanate - UltraBio™, Suitable for molecular biology, ≥99%(AT) , CAS No.593-84-0

CAS: 593-84-0 Cat. No.: G755627 Molecular Weight: 118.16 Beilstein Registry Number: 3563461 EC Number: 209-812-1
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GRADE & PURITY Suitable for molecular biology ? Molecular-biology grade — free of nucleases and contaminants that degrade DNA/RNA. Use in cloning, PCR, and nucleic-acid work needing clean reagents. UltraBio™ ? UltraBio™ — Aladdin's line for molecular-biology applications. Use for nuclease-free, high-consistency reagents across molecular workflows. ≥99%(AT)
Storage
Room temperature
Shipped In
Normal
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Size
Status
Price
Qty
25g
G755627-25g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$373.90
100g
G755627-100g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$1,017.90
250g
G755627-250g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$2,445.90
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Why this grade

UltraBio™, Suitable for molecular biology, ≥99%(AT) Suitable for molecular biology,UltraBio™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 39 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Chaotropic agent and strong denaturant; solubilizes cells.

Specifications

Specifications & Purity
UltraBio™, Suitable for molecular biology, ≥99%(AT)
Storage
Room temperature
Shipped In
Normal
Grade
Suitable for molecular biology, UltraBio™
Purity
≥99%(AT)
Names and Identifiers
PH4.5-7.0 (25 °C, 6 M in H 2 O)
Canonical SmilesC(#N)S.C(=N)(N)N
IUPAC Nameguanidine;thiocyanic acid
InChIKeyZJYYHGLJYGJLLN-UHFFFAOYSA-N
INCHI1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H
Isomeric SMILES C(#N)S.C(=N)(N)N
WGK Germany 2
RTECS XL1225000
UN Number 1759
Packing Group III
Molecular Weight 118.16
Beilstein 3563461
Reaxy-Rn 3563461
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3563461&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganosulfur compounds
ClassThiocyanates
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentThiocyanates
Alternative Parents Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkNot available
Substituents Thiocyanate - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as thiocyanates. These are salts or esters of thiocyanic acid, with the general formula RSC#N (R=alkyl, aryl).
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilityH 2 O: 6 M at 20 °C, clear, colorless
Melt Point(°C)118-122°C
Molecular Weight118.160 g/mol
XLogP3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass118.031 Da
Monoisotopic Mass118.031 Da
Topological Polar Surface Area101.000 Ų
Heavy Atom Count7
Formal Charge0
Complexity57.600
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Documents & Articles
UltraBio™: Defining Excellence in Molecular Biology Applications
Molecular Biology Grade
How Biotinylated Molecules are Purified with Streptavidin Beads
A Review of Ten Commonly Used Techniques for Detection, Quantification, and Interaction Analysis in Nucleic Acid Research
Plant Omics Panorama: Workflow Frameworks and Multi-Omics Integration from Genomics to Transcriptomics, Proteomics, and Metabolomics
RNA Extraction Technologies: Method Systems, Operational Workflows, and Key Quality-Control Considerations
Interleukin-29 (IL-29/IFN-λ1): Molecular Features, Signaling Networks, and a Systematic Framework for Research Applications
dsDNase-Mediated Hydrolysis of Double-Stranded DNA: Enzymatic Characteristics, Methodological Strategies, and Bioanalytical Applications
Comparative Principles and Selection of CTAB, SDS, TRIzol, and Column-Based Purification Systems in Nucleic Acid Extraction from Plant Samples
Selection Strategies for Release, Precipitation, Co-Precipitation, and Contaminant Removal Systems in Nucleic Acid Sample Pretreatment
Citations of This Product
References
1. Jie Lian, Wenyu Gong, Jianing Guo, Mingxing Wu.  (2024)  Design highly effective B or N doped mesoporous carbon fibers catalysts for I3-/I- redox couple regeneration in carbon-based dye-sensitized solar cells.  Arabian Journal of Chemistry,      [PMID:] [10.1016/j.arabjc.2024.105817]
2. Chunmei Lv, Jing Liu, Borong Lu, Ke Ye, Guiling Wang, Kai Zhu, Dianxue Cao, Ying Xie.  (2024)  Iron-doping and facet engineering of NiSe octahedron for synergistically enhanced triiodide reduction activity in photovoltaics.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:38430837] [10.1016/j.jcis.2024.02.193]
3. Baorui Liu, Hongqing Cheng, Fangchao Cheng, Dongying Hu.  (2025)  Lignosulfonate-Induced orientation of Poly(3,4-ethlylenedioxythiophene) for enhanced efficiency in bifacial Dye-Sensitized solar cells.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.159499]
4. Yanjun Xing, Zhiqiang Deng, Qiuxiang Wang, Jiaxing Xiong, Xiaohui Liu, Like Huang, Yuejin Zhu, Jing Zhang.  (2024)  Polymer Lewis Base for Improving the Charge Transfer in Tin–Lead Mixed Perovskite Solar Cells.  Nanomaterials,  14  (5): (437).  [PMID:38470768] [10.3390/nano14050437]
5. Wei Ding, Chen Bai, Yuxuan Ren, Dong Fang, Jing Bai, Jiali Wen, Baoxiu Mi, Dapeng Cao, Zhiqiang Gao.  (2024)  Synergetic effects of recombination-blocking, band-bending and gap-state manipulation by interfacial engineering in solid-state DSSCs comprising Cs2SnI6 electrolyte.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2024.104246]
6. Wenpeng Wu, Xinqun Zhang, Yukun Xiao, Zhihua Cheng, Tian Yang, Jinsheng Lv, Man Yuan, Jiajia Liu, Yang Zhao.  (2023)  Highly Salt-tolerant hydrogen evolution reaction based on dendritic urchin-like MoC/MoS2 heterojunction in seawater.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.148085]
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10. Shoudeng Zhong, Zhuoxi Li, Chunqiu Zheng, Xinyi Luo, Jinwei Gao, Xubing Lu, Xingsen Gao, Lingling Shui, Sujuan Wu, Jun-Ming Liu.  (2022)  Guanidine Thiocyanate-Induced High-Quality Perovskite Film for Efficient Tin-Based Perovskite Solar Cells.  Solar RRL,  (7): (2200088).  [PMID:] [10.1002/solr.202200088]
11. Siwenjie Qian, Yanju Chen, Cheng Peng, Xiaofu Wang, Hui Wu, Yang Che, Huanying Wang, Junfeng Xu, Jian Wu.  (2022)  Dipstick-based rapid nucleic acids purification and CRISPR/Cas12a-mediated isothermal amplification for visual detection of African swine fever virus.  TALANTA,      [PMID:35149424] [10.1016/j.talanta.2022.123294]
12. Li Sun, Tao Zhang, Ying Liu, Jianxin Wang, Wei Zong, Yuying Cao, Xiuwen Wang.  (2021)  Hierarchical NiSe microspheres as high-efficiency counter electrode catalysts for triiodide reduction reaction.  SOLAR ENERGY,      [PMID:] [10.1016/j.solener.2021.07.058]
13. Hui Wu, Yanju Chen, Qunqing Yang, Cheng Peng, Xiaofu Wang, Mengyao Zhang, Siwenjie Qian, Junfeng Xu, Jian Wu.  (2021)  A reversible valve-assisted chip coupling with integrated sample treatment and CRISPR/Cas12a for visual detection of Vibrio parahaemolyticus.  BIOSENSORS & BIOELECTRONICS,      [PMID:34038837] [10.1016/j.bios.2021.113352]
14. Xu Chen, Yang Zhang, Yashuai Pang, Qiwei Jiang.  (2020)  Facile Synthesis of Nanoporous NiS Film with Inverse Opal Structure as Efficient Counter Electrode for DSSCs.  Materials,  13  (20): (4647).  [PMID:33080967] [10.3390/ma13204647]
15. Dongjing Liu, Lingtao Yang, Bin Li, Jiang Wu.  (2020)  Gaseous mercury removal by graphene-like carbon nitride impregnated with ammonium bromide.  FUEL,      [PMID:] [10.1016/j.fuel.2020.118635]
16. Zhenxing Qin, Wenhai Wang, Xiaozhi Zhan, Xiujuan Du, Qingmei Zhang, Rui Zhang, Kun Li, Jinhong Li, Weiping Xu.  (2018)  One-pot synthesis of dual carbon dots using only an N and S co-existed dopant for fluorescence detection of Ag+.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:30312843] [10.1016/j.saa.2018.10.004]
17. Xiaoyan Wang, Ying Xie, Zhicheng Cai, Ni Xiong, Zhikun Xu, Mingxia Li, Qingmao Feng, Wei Zhou, Kai Pan.  (2018)  The sesame ball-like CoS/MoS2 nanospheres as efficient counter electrode catalysts for dye-sensitized solar cells.  JOURNAL OF ALLOYS AND COMPOUNDS,      [PMID:] [10.1016/j.jallcom.2017.12.345]
18. Panpan Sun, Taian Huang, Ziyu Chen, Liangyu Tian, Huihui Huang, Niu Huang, Sha Zhou, Min Long, Yihua Sun, Xiaohua Sun.  (2017)  Solution Processed NixSy Films: Composition, Morphology and Crystallinity Tuning via Ni/S-Ratio-Control and Application in Dye-Sensitized Solar Cells.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2017.06.023]
19. Niu Huang, Lin Chen, Hua Huang, Weiwei Sun, Shouzheng Zhang, Panpan Sun, Xiaohua Sun, Peng Xiang, Yihua Sun, Xingzhong Zhao.  (2015)  Bilayer TiO2 Photoanode Consisting of Microspheres and Pyramids with Reinforced Interface Connection and Light Utilization for Dye-Sensitized Solar Cells.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2015.08.113]
20. Hong Tao, Wanping Chen, Jing Wang, Weijun Ke, Jiawei Wan, Jionghua Wu, Guo-jia Fang.  (2014)  Low-temperature synthesis of size-controllable anatase TiO2 microspheres and interface optimization of bi-layer anodes for high efficiency dye sensitized solar cells.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2014.05.133]
21. Weijun Ke, Guojia Fang, Hong Tao, Pingli Qin, Jing Wang, Hongwei Lei, Qin Liu, Xingzhong Zhao.  (2014)  In Situ Synthesis of NiS Nanowall Networks on Ni Foam as a TCO-Free Counter Electrode for Dye-Sensitized Solar Cells.  ACS Applied Materials & Interfaces,      [PMID:24660877] [10.1021/am4059155]
22. Wei Zeng, Mingjun Wang, Yuan Li, Jiawei Wan, Huihui Huang, Hong Tao, David L. Carroll, Xingzhong Zhao, Dechun Zou, Guojia Fang.  (2014)  Semi-closed tubular light-trapping geometry dye sensitized solar cells with stable efficiency in wide light intensity range.  JOURNAL OF POWER SOURCES,      [PMID:] [10.1016/j.jpowsour.2014.03.050]
23. Pengfei Qiang, Peihua Yang, Zhiwen Liang, Yunhan Luo, Jianhui Yu, Yu Lan, Xiang Cai, Shaozao Tan, Pengyi Liu, Wenjie Mai.  (2013)  General strategy for improving dye-sensitized solar cells by using sub-micrometer cavities.  JOURNAL OF ALLOYS AND COMPOUNDS,      [PMID:] [10.1016/j.jallcom.2013.08.158]
24. Wei Zeng, Guojia Fang, Tianyang Han, Borui Li, Nishuang Liu, Dongshan Zhao, Zhiqiang Liu, Dianyuan Wang, Xingzhong Zhao, Dechun Zou.  (2013)  In situ synthesis of binded, thick and porous carbon nanoparticle dye sensitized solar cell counter electrode with nickel gel as catalyst source.  JOURNAL OF POWER SOURCES,      [PMID:] [10.1016/j.jpowsour.2013.06.157]
25. Hong Tao, Guo-jia Fang, Wei-jun Ke, Wei Zeng, Jing Wang.  (2013)  In-situ synthesis of TiO2 network nanoporous structure on Ti wire substrate and its application in fiber dye sensitized solar cells.  JOURNAL OF POWER SOURCES,      [PMID:] [10.1016/j.jpowsour.2013.06.103]
26. Chaolei Wang, Liang Wang, Yantao Shi, Hong Zhang, Tingli Ma.  (2012)  Printable electrolytes for highly efficient quasi-solid-state dye-sensitized solar cells.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2012.12.096]
27. Wei Zeng, Guojia Fang, Xueqi Wang, Qiao Zheng, Borui Li, Huihui Huang, Hong Tao, Nishuang Liu, Weijun Xie, Xingzhong Zhao, Dechun Zou.  (2012)  Hierarchical porous nano-carbon composite: Effective fabrication and application in dye sensitized solar cells.  JOURNAL OF POWER SOURCES,      [PMID:] [10.1016/j.jpowsour.2012.12.021]
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34. Xuan Wang, Hmbat Batelbek, Xin Guo, Yanan Li, Yuzhu Wang, Fan Yang, Yinglin Wang, Xintong Zhang.  (2025)  Thermal-Assisted Fracture Healing Realizing High-Accuracy Polymer Crack Lithography.  ACS Applied Materials & Interfaces,      [PMID:41203566] [10.1021/acsami.5c10316]
35. Jiaqi Wang, Zhirui Chen, Ye Song, Chang Li, Caixuan Wang, Jingjing Hui, Junyu Nie, Yi Wang, Zhihai Cheng, Qi Li, Cheng Mu.  (2025)  Internal Bridging Engineering of NiOx/Me-4PACz via Selective Guanidine-based Hydrochlorides for Efficient and Stable Inverted Perovskite Solar Cells.  PHYSICAL CHEMISTRY CHEMICAL PHYSICS,      [PMID:41400480] [10.1039/D5CP02853A]
36. Zhen-Yu Zhao, Ya-Ning Che, Qian Huang, Han-Wen Yang, Xian-Hua Wang, Lin-Yi Dong.  (2025)  Rapid and sensitive detection of Candida albicans using nystatin-functionalized magnetic spheres.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:41447893] [10.1016/j.jchromb.2025.124896]
37. Shuli Yu, Shihong Zhu, Shuai Dong, Kun Zhao, Ting Tao, Jia Yang, Daohang Du, Yunhua Jiang, Yifeng Xing, Yue Gao, Hongbing Xing, Zhifei Wang.  (2026)  Solvothermal one-pot synthesis of carboxylated poly (vinyl alcohol)-coated magnetite nanoparticles for high-efficiency nucleic acid extraction.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2026.139568]
38. Jiaqi Wang, Zhirui Chen, Haojie You, Linshan Li, Junyu Nie, Ziyue Jiao, Caixuan Wang, Zhihai Cheng, Yi Wang, Qi Li, Cheng Mu.  (2026)  Stress-Regulated Crystallization on Mesoporous Nickel Oxide Enables High-Efficiency and Stable Inverted Perovskite Solar Cells.  Journal of Physical Chemistry Letters,      [PMID:41591345] [10.1021/acs.jpclett.5c03815]
39. Ruoyu Dong, Weijie Ren, Jialong Dong, Yufei Zhang, Shuai Meng, Zhaoyi Jiang, Kai Song, Rui Zhang, Kun Li, Zhenxing Qin.  (2026)  Engineering multi-peak emitting carbon dots-based crystalloids towards flexible luminescent solar concentrator-integrated photovoltaics.  OPTICAL MATERIALS,      [PMID:] [10.1016/j.optmat.2026.118020]
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