What is the relationship between the specific activity expressed as an ED50 and as units/mg?
What is the relationship between the specific activity expressed as an ED50 and as units/mg?
posted this at Jun 9, 2025 Updated at Oct 9, 2023
What is the relationship between the specific activity expressed as an ED50 and as units/mg?
While ED50 is defined as the cytokine concentration at which activity is 50% of the maximum response, specific activity is defined as a measurement of reaction rate (i.e. activity) in relation to the amount or mass of a substance. Specific Activity Units should only be used as a method of expressing potency and should only be calculated for sigmoidal dose-dependent curves. The formula for converting activity expressed as an ED50 in ng/ml to specific activity in units/mg is:
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