Relatlimab (anti-LAG-3/CD223) - Primary antibody, for Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR) various applications, specific to LAG3/CD223, >95%, Human IgG4SP, Antibody of LAG3 (CD223), Antibody of LAG3 (CD223)

CAS: 1673516-98-7 Cat. No.: Ab169321

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human

Isotype

Human IgG4SP

Conjugation

Unconjugated

Overview

Relatlimab (anti-LAG-3/CD223) is a human LAG-3 specific monoclonal antibody that binds to LAG-3 on T cells, restoring effector function of exhausted T cells.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Relatlimab (anti-LAG-3/CD223) - Primary antibody, for Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR) various applications, specific to LAG3/CD223, >95%, Human IgG4SP, Antibody of LAG3 (CD223)

Synonyms

BMS-986016 | RELA | CD223 antibody | CD223 antigen antibody | FDC protein antibody | LAG-3 antibody | Lag3 antibody | LAG3_HUMAN antibody | Lymphocyte activating 3 antibody | Lymphocyte activation gene 3 antibody | Lymphocyte activation gene 3 protein ant

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

LAG3/CD223

Application

Flow, ELISA, Functional Assay, Kinetics (BLI), Kinetics (SPR)

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

INHIBITOR

Mechanism of action

Antibody of LAG3 (CD223)

Antibody Type

Primary antibody

Clonality

Recombinant

Isotype

Human IgG4SP

Light Chain Type

kappa

SDS-PAGE

27.1 kDa (Light Chain) & 53.4 kDa (Heavy Chain), under reducing conditions; 176.6 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Source

CHO supernatant

Concentration

See COA

CAS

1673516-98-7

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Flow Cytometry: Relatlimab (anti-LAG-3/CD223) (Ab169321)

Relatlimab (anti-LAG-3/CD223) (Ab169321) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood mononuclear lymphocytes labelling LAG-3/CD223 (red) with Relatlimab (anti- LAG-3/CD223) (Ab169321). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Relatlimab (anti-LAG-3/CD223) (Ab169321)

Relatlimab (anti-LAG-3/CD223) (Ab169321) - SEC
The purity of Relatlimab (anti-LAG-3/CD223) (Ab169321) is more than 95% verified by HPLC.

ELISA: Relatlimab (anti-LAG-3/CD223) (Ab169321)

Relatlimab (anti-LAG-3/CD223) (Ab169321) - ELISA
Immobilized Recombinant Human LAG-3 protein (rp176292) at 1.0 μg/mL can bind Relatlimab (anti-LAG-3/CD223) (Ab169321) with the EC₅₀ of 41.53 ng/mL.​

Associated Targets(Human)

LAG3 Tclin Lymphocyte activation gene 3 protein (0 Activities)

Discover Target: LAG3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action