Mosunetuzumab (anti-CD20&CD3e) - Primary antibody, specific to MS4A1 & CD3E, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e

CAS: 1905409-39-3 Cat. No.: Ab175605

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Human

Isotype

Human IgG1

Conjugation

Unconjugated

Overview

Mosunetuzumab (anti-CD20 & CD3e) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab (anti-CD20 & CD3e) redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs).
Purity
≥90% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg

Specifications

Product Name

Mosunetuzumab (anti-CD20&CD3e) - Primary antibody, specific to MS4A1 & CD3E, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e

Synonyms

APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | B-lymphocyte cell-surface antigen B1 antibody | B-lymphocyte surface antigen B1 antibody | B1 antibod

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

MS4A1 & CD3E

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

BINDING AGENT

Mechanism of action

Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e

Isotype

Human IgG1

Light Chain Type

kappa

SDS-PAGE

146.72 kDa

Purification Method

Protein A purified

Concentration

See COA

CAS

1905409-39-3

Storage and Shipping

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Flow Cytometry: Mosunetuzumab (anti-CD20&CD3e) (Ab175605)

Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD20&CD3e (red) with Mosunetuzumab (anti-CD20&CD3e) (Ab175605) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Mosunetuzumab (anti-CD20&CD3e) (Ab175605)

Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD20&CD3e (red) with Mosunetuzumab (anti-CD20&CD3e) (Ab175605) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Mosunetuzumab (anti-CD20&CD3e) (Ab175605)

Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - SEC
The purity of Mosunetuzumab (anti-CD20&CD3e) (Ab175605) is more than 95% verified by HPLC.

Associated Targets(Human)

MS4A1 Tclin B-lymphocyte antigen CD20 (0 Activities)

Discover Target: MS4A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 Activities)

Discover Target: CD3E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MS4A1 Tclin B-lymphocyte antigen CD20 (0 Activities)

Discover Target: MS4A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 Activities)

Discover Target: CD3E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action