Morpholine - AR, ≥99% , CAS No.110-91-8

CAS: 110-91-8 Cat. No.: M109062 Molecular Weight: 87.12 Beilstein Registry Number: 102549 EC Number: 203-815-1
AVAILABLE TO ORDER
GRADE & PURITY AR ? Analytical Reagent grade — high-purity chemicals meeting strict assay limits for lab analysis. Use when accuracy matters and trace impurities could skew results. ≥99%
Synonyms
Drewamine | NCGC00256942-01 | J-522715 | 4-27-00-00015 (Beilstein Handbook Reference) | Diethyleneimide oxide | Tetrahydro-1,4-isoxazine | UNII-8B2ZCK305O | Tetrahydro-1, 4-isoxazine | TETRAHYDRO-2H-1, 4-OXAZINE | Tetrahydro-4H-1-4-oxazine | Drewamine
Storage
Room temperature,Argon charged
Shipped In
FedEx DG Service
Size
Status
Price
Qty
100ml
M109062-100ml
10

$13.90

$23.90
Save $10.00 (41.84%)
500ml
M109062-500ml
3

$22.90

$30.90
Save $8.00 (25.89%)
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Why this grade

AR, ≥99% AR for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature,Argon charged Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 42 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
Drewamine | NCGC00256942-01 | J-522715 | 4-27-00-00015 (Beilstein Handbook Reference) | Diethyleneimide oxide | Tetrahydro-1, 4-isoxazine | UNII-8B2ZCK305O | Tetrahydro-1, 4-isoxazine | TETRAHYDRO-2H-1, 4-OXAZINE | Tetrahydro-4H-1-4-oxazine | Drewamine
Specifications & Purity
AR, ≥99%
Storage
Room temperature, Argon charged
Shipped In
FedEx DG Service
Grade
AR
Purity
≥99%
Names and Identifiers
Pubchem Sid504751569
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504751569
Canonical SmilesC1COCCN1
IUPAC Namemorpholine
InChIKeyYNAVUWVOSKDBBP-UHFFFAOYSA-N
INCHI1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2
Isomeric SMILES C1COCCN1
WGK Germany 1
RTECS QD6475000
UN Number 2054
Packing Group I
Molecular Weight 87.12
Beilstein 102549
Reaxy-Rn 102549
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=102549&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassOxazinanes
SubclassMorpholines
Intermediate Tree Nodes Not available
Direct ParentMorpholines
Alternative Parents Oxacyclic compounds  Dialkylamines  Dialkyl ethers  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents Morpholine - Oxacycle - Azacycle - Secondary amine - Ether - Secondary aliphatic amine - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as morpholines. These are organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively.
External Descriptors morpholines - saturated organic heteromonocyclic parent
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

38 results found

Lot NumberCertificate TypeDateItem
G2607148Certificate of AnalysisJun 29, 2026 M109062
G2607195Certificate of AnalysisJun 29, 2026 M109062
J2513021Certificate of AnalysisApr 03, 2025 M109062
E2523104Certificate of AnalysisApr 03, 2025 M109062
C2627186Certificate of AnalysisApr 03, 2025 M109062
E2523103Certificate of AnalysisApr 03, 2025 M109062
E2523102Certificate of AnalysisApr 03, 2025 M109062
C2504465Certificate of AnalysisFeb 26, 2025 M109062
C2504466Certificate of AnalysisFeb 26, 2025 M109062
C2504467Certificate of AnalysisFeb 26, 2025 M109062
K2426743Certificate of AnalysisNov 14, 2024 M109062
K2426740Certificate of AnalysisNov 14, 2024 M109062
I2404043Certificate of AnalysisAug 28, 2024 M109062
I2404042Certificate of AnalysisAug 28, 2024 M109062
I2404020Certificate of AnalysisAug 28, 2024 M109062
H2402355Certificate of AnalysisMay 06, 2024 M109062
G2425729Certificate of AnalysisMay 06, 2024 M109062
G2425766Certificate of AnalysisMay 06, 2024 M109062
B2519127Certificate of AnalysisApr 28, 2024 M109062
D2410398Certificate of AnalysisApr 02, 2024 M109062
D2410397Certificate of AnalysisApr 02, 2024 M109062
D2410395Certificate of AnalysisApr 02, 2024 M109062
C2411032Certificate of AnalysisMar 19, 2024 M109062
G23151054Certificate of AnalysisJul 04, 2023 M109062
G23151057Certificate of AnalysisJul 04, 2023 M109062
G23151056Certificate of AnalysisJul 04, 2023 M109062
G23151045Certificate of AnalysisJul 04, 2023 M109062
B2322798Certificate of AnalysisFeb 15, 2023 M109062
B2322847Certificate of AnalysisFeb 15, 2023 M109062
B2322828Certificate of AnalysisFeb 15, 2023 M109062
K2210346Certificate of AnalysisNov 01, 2022 M109062
K2210347Certificate of AnalysisNov 01, 2022 M109062
K2210348Certificate of AnalysisNov 01, 2022 M109062
H2203029Certificate of AnalysisJun 13, 2022 M109062
I2208382Certificate of AnalysisJun 13, 2022 M109062
F2227003Certificate of AnalysisJun 13, 2022 M109062
F2225387Certificate of AnalysisJun 13, 2022 M109062
F2225386Certificate of AnalysisJun 13, 2022 M109062

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Chemical and Physical Properties
SolubilityIt is miscible with water and can be miscible with most organic solvents.
SensitivityHygroscopic;Air sensitive
Refractive Index1.4548
Flash Point(°F)87.8 °F
Flash Point(°C)35℃
Boil Point(°C)128.3°C
Melt Point(°C)-4.76°C
Molecular Weight87.120 g/mol
XLogP3-0.900
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass87.0684 Da
Monoisotopic Mass87.0684 Da
Topological Polar Surface Area21.300 Ų
Heavy Atom Count6
Formal Charge0
Complexity34.500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
OSF/ASF Dual-Channel Toolbox: Divergent Reactions of Four-Membered Ring Sulfonyl Fluorides, Condition “Knobs,” and Selection Navigation
Make “Aryl Chlorides + Low Pd Loading + Scale-Up Reproducibility” Reliable: The Initiation and Durability Logic of Pd–NHC (Palladium–N-Heterocyclic Carbene) Cross-Coupling (with Selection Navigation and Product Tables)
Why Do So Many Molecules Incorporate an “Oxadiazole Ring”? A Stability-Oriented Design Guide from Structural Effects to Application Storylines (with Product Navigation Tables 1–3)
Haloheterocycles and Cross-Coupling: A Research-Oriented Selection Framework from Substrate Identification to Bond-Forming Routes (Including Product Navigation and Tables 1–5)
β-Acyloxy Alkenyl Amides (AAAs): A New Approach to Amide Bond and Peptide Bond Construction Worth Attention
DAST-Mediated Amidation at Room Temperature: Method Features, Practical Value, and Scope of Applicability
Triphenylphosphine-Involved Carboxylic Acid Activation and Amide Bond Formation: Activation Pathways, Anhydride Competition, and Applicability Scenarios
Experimental Decision-Making for Cross-Coupling Reactions: Target Bond Type, Substrate Combination, and Catalytic System Selection
Application of Shellac, a Natural Film-Forming Resin, in Coatings: Alcohol-Soluble Fast-Drying Film Formation, Sealing and Repair, and Performance Boundaries
Rationale for Applying Spirocyclic Building Blocks in Drug Molecule Optimization: Three-Dimensionalization, Conformational Control, and Property Trade-offs
Medicinal Chemistry Value of Heteroatom-Containing Small-Ring Spirocycles: Classical Heterocycle Replacement and Three-Dimensional Exit Vector Remodeling
Citations of This Product
References
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