Recombinant Aprotinin, Inhibitor of plasminogen, CAS No.9087-70-1, Inhibitor of plasminogen

CAS: 9087-70-1 Cat. No.: R426862 Molecular Weight: 6511.44 EC Number: 232-994-9 PubChem CID: 22833874

GRADE & PURITY EnzymoPure™, 10mM in Water

Overview

Aprotinin is a competitive serine protease inhibitor that inhibits trypsin,chymotrypsin,kallikrein and plasmin.Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin,protease complexes and dissociating at pH >10 or <3. Effective concentration is equimolar with protease.Recombinant aprotinin is expressed in E. Coli, and purified with HPLC. It contains no animal-derived components. This is a recombinant form of bovine lung aprotinin, which is traditionally isolated from bovine lung by methods involving fractional precipitation, gel filtration, and ion exchange chromatography. UNIT DEFINITION:A conversion factor for Aprotinin is: 1 EPU = 1 USP Aprotinin Unit = 1800 KIU.

Specifications

Product Name

Recombinant Aprotinin, Inhibitor of plasminogen, CAS No.9087-70-1

Synonyms

Antilysin | APROTININ | 9087-70-1 | Aprotinin from bovine lung | Traskolan | Bovine Pancreatic Trypsin Inhibitor | AKOS024457997 | CCG-270718 | J-200086

Grade

EnzymoPure™

Specifications & Purity

EnzymoPure™, 10mM in Water

Biochemical and Physiological Mechanisms

Expressed in E. Coli

Action Type

INHIBITOR

Mechanism of action

Inhibitor of plasminogen

CAS

9087-70-1

Molecule Type

Enzyme

Storage and Shipping

Concentration

10mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic Polymers
    • Class Polypeptides

• Kingdom: Organic compounds
• Superclass: Organic Polymers
• Class: Polypeptides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Polypeptides
• Alternative Parents: Cyclic peptides Phenylalanine and derivatives Pentacarboxylic acids and derivatives Aspartic acid and derivatives N-acyl-alpha amino acids Proline and derivatives Alpha amino acid amides Alanine and derivatives Amphetamines and derivatives Pyrrolidinecarboxamides N-acylpyrrolidines 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Tertiary carboxylic acid amides Secondary alcohols Guanidines Amino acids Organic disulfides Secondary carboxylic acid amides Lactams Primary carboxylic acid amides Sulfenyl compounds Azacyclic compounds Carboximidamides Carboxylic acids Dialkylthioethers Primary alcohols Imines Carbonyl compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Monoalkylamines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Polypeptide - Cyclic alpha peptide - Phenylalanine or derivatives - Pentacarboxylic acid or derivatives - Aspartic acid or derivatives - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Proline or derivatives - Alpha-amino acid amide - Alanine or derivatives - Amphetamine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Fatty acyl - Benzenoid - N-acyl-amine - Fatty amide - Pyrrolidine - Tertiary carboxylic acid amide - Organic disulfide - Amino acid or derivatives - Primary carboxylic acid amide - Carboxamide group - Amino acid - Secondary alcohol - Secondary carboxylic acid amide - Lactam - Guanidine - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Dialkylthioether - Sulfenyl compound - Carboximidamide - Thioether - Hydrocarbon derivative - Organic oxide - Amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Alcohol - Imine - Primary aliphatic amine - Primary amine - Primary alcohol - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PLG Tclin Plasminogen (0 Activities)

Discover Target: PLG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Genetic information

• Alternate Names: Antilysin|APROTININ|9087-70-1|Aprotinin from bovine lung|Traskolan|Bovine Pancreatic Trypsin Inhibitor|AKOS024457997|CCG-270718|J-200086
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