ADC Linkers: Key Units That Regulate the In Vivo Stability, Payload Release, and Efficacy and Safety of Antibody–Drug Conjugates

Antibody–drug conjugates (ADCs) consist of three components: a monoclonal antibody, a linker, and a cytotoxic payload. The antibody is responsible for recognizing tumor-associated antigens, the payload is responsible for killing cells, and the linker determines whether the payload can be ...