Leronlimab (anti-CCR5) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CCR5/CD195, >95%, Human IgG4SP, Antibody of CCR5, Antibody of CCR5

CAS: 674782-26-4 Cat. No.: Ab169252

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Human, Rhesus monkey

Isotype

Human IgG4SP

Conjugation

Unconjugated

Overview

Leronlimab (anti-CCR5) is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.
In vitro
Leronlimab binds CCR5 in multiple breast cancer cell lines, reducing ligand-induced Ca2+ signaling, invasion of TNBC into Matrigel, and transwell migration, also enhances the breast cancer (BCa) cell killing of the BCa chemotherapy reagent, doxorubicin.
In vivo
In xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg 

Specifications

Product Name

Leronlimab (anti-CCR5) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CCR5/CD195, >95%, Human IgG4SP, Antibody of CCR5

Synonyms

Recombinant Leronlimab Antibody | Leronlimab (anti-CCR5) | PRO 140 | Vyrologi | Leronlimab | AM4 7 antibody | C C chemokine receptor type 5 antibody | C C CKR 5 antibody | C-C chemokine receptor type 5 antibody | C-C CKR-5 antibody | C-C motif chemokine r

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

CCR5/CD195

Application

ELISA, Functional Assay, Flow cytometry, Kinetics (BLI), Kinetics (SPR)

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

ANTAGONIST

Mechanism of action

Antibody of CCR5

Antibody Type

Primary antibody

Clonality

Recombinant

Isotype

Human IgG4SP

Light Chain Type

kappa

SDS-PAGE

27.7 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 169.8 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Source

CHO supernatant

Concentration

See COA

CAS

674782-26-4

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

SEC: Leronlimab (anti-CCR5) (Ab169252)

Leronlimab (anti-CCR5) (Ab169252) - SEC
The purity of Leronlimab (anti-CCR5) (Ab169252) is more than 95% verified by HPLC.

Associated Targets(Human)

CCR5 Tclin C-C chemokine receptor type 5 (0 Activities)

Discover Target: CCR5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCR5 Tclin C-C chemokine receptor type 5 (5640 Activities)

Discover Target: CCR5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action