Pepstatin A TFA, CAS No.26305-03-3(free)

CAS: 26305-03-3(free) Cat. No.: P359425 Molecular Weight: 799.9 EC Number: 247-600-0
AVAILABLE TO ORDER
GRADE & PURITY ≥97%
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
10mg
P359425-10mg
2
$99.90
50mg
P359425-50mg
2
$329.90
100mg
P359425-100mg
2
$569.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Product Description

Pepstatin A is a specific inhibitor of L-aspartic Acid produced by actinomycetes. It can inhibit the activities of hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease. The IC50 values are 4.5 nM, 6.2 nM, 150 nM, 290 nM, respectively, 520nm and 260nm, and inhibit the activity of HIV protease.

Product Application

Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.

Specifications

Product Name
Pepstatin A TFA, CAS No.26305-03-3(free)
Synonyms
3-hydroxy-4-[2-[[3-hydroxy-6-methyl-4-[[3-methyl-2-[[3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoylamino]-6-methylheptanoic acid TFA
Specifications & Purity
≥97%
Biochemical and Physiological Mechanisms
Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thio
Sequence
IsoValeryl-Val-Val-Sta-Ala-Sta-OH
CAS
26305-03-3(free)
Molecule Type
Small molecule
Storage and Shipping
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassPeptidomimetics
SubclassHybrid peptides
Intermediate Tree Nodes Not available
Direct ParentHybrid peptides
Alternative Parents Dipeptides  Valine and derivatives  N-acyl-alpha amino acids and derivatives  Alpha amino acid amides  Gamma amino acids and derivatives  Alanine and derivatives  Medium-chain hydroxy acids and derivatives  Medium-chain fatty acids  Amino fatty acids  Beta hydroxy acids and derivatives  Methyl-branched fatty acids  Hydroxy fatty acids  N-acyl amines  Secondary carboxylic acid amides  Secondary alcohols  Monocarboxylic acids and derivatives  Carboxylic acids  Carbonyl compounds  Organopnictogen compounds  Organic oxides  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic acyclic compounds
Substituents Hybrid peptide - Alpha-dipeptide - N-acyl-alpha amino acid or derivatives - Valine or derivatives - Alpha-amino acid amide - Gamma amino acid or derivatives - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Medium-chain hydroxy acid - Medium-chain fatty acid - Amino fatty acid - Beta-hydroxy acid - Hydroxy fatty acid - Branched fatty acid - Methyl-branched fatty acid - Fatty acyl - Fatty acid - Fatty amide - N-acyl-amine - Hydroxy acid - Secondary carboxylic acid amide - Carboxamide group - Secondary alcohol - Carboxylic acid - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Organic nitrogen compound - Carbonyl group - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CTSL Tclin Cathepsin L1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CTSE Tchem Cathepsin E (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PGA5 Tclin Pepsin A-5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
REN Tclin Renin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CTSD Tchem Cathepsin D (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADAM9 Tchem Disintegrin and metalloproteinase domain-containing protein 9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
B23271068Certificate of AnalysisAug 23, 2022 P359425
B23271072Certificate of AnalysisAug 23, 2022 P359425
B23271113Certificate of AnalysisAug 23, 2022 P359425
B23271114Certificate of AnalysisAug 23, 2022 P359425
B2327972Certificate of AnalysisAug 23, 2022 P359425
B2327974Certificate of AnalysisAug 23, 2022 P359425
B2628200Certificate of AnalysisAug 23, 2022 P359425
Documents & Articles
BN-PAGE Protocol
Dual Cross-linking ChIP Protocol
Protease Inhibitors
How to Optimize Buffer Components for Ni-Agarose Beads
Pepsin——Structural Features, Enzymatic Properties, and Experimental Application Guide
Review of Chymotrypsin: Enzymological Properties, Catalytic Mechanism, and Research Applications
Review of Collagenase: Enzymological Features, Type Systems, and Research Applications
Roles of the Carboxypeptidase Family in Protein C-Terminal Processing and Experimental Analysis
Solution Calculators
Reviews

Customer Reviews

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