Tilvestamab (anti-AXL) - Primary antibody, specific to AXL, Human IgG1

CAS: 2226775-26-2 Cat. No.: Ab182880
AVAILABLE TO ORDER
GRADE & PURITY Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Human
Reactive species
Cynomolgus monkey, Human
Isotype
Human IgG1
Conjugation
Unconjugated
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
100μg
Ab182880-100μg
10
$107.90
1mg
Ab182880-1mg
4
$531.90
5mg
Ab182880-5mg
1
$1,399.90
10mg
Ab182880-10mg
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$2,239.90
Enter a quantity for the sizes you want to add.
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Why this grade

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C,Avoid repeated freezing and thawing Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Tilvestamab (anti-AXL) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab (anti-AXL) significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab (anti-AXL) can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas.

Purity

>95% (SDS-PAGE&SEC)

Endotoxin Level

< 1.0EU/mg


Specifications

Product Name
Tilvestamab (anti-AXL) - Primary antibody, specific to AXL, Human IgG1
Synonyms
Adhesion related kinase antibody | AI323647 antibody | Ark antibody | Axl antibody | AXL oncogene antibody | AXL receptor tyrosine kinase antibody | AXL transforming gene antibody | AXL transforming sequence/gene antibody | EC 2.7.10.1 antibody | JTK11 an
Specifications & Purity
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species
Human
Specificity
AXL
Conjugation
Unconjugated
Grade
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
27.1 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 198.5 kDa, under non-reducing conditions.
Purification Method
Protein A purified
Concentration
See COA
CAS
2226775-26-2
Storage and Shipping
Shape
Liquid
Storage
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Dry ice packs + Cold packs
Stability And Storage
Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
Images

Tilvestamab (anti-AXL) (Ab182880) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling AXL (red) with Tilvestamab (anti-AXL) (Ab182880). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Tilvestamab (anti-AXL) (Ab182880) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling AXL (red) with Tilvestamab (anti-AXL) (Ab182880). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Tilvestamab (anti-AXL) (Ab182880) - Flow Cytometry
Human AXL HEK293 cells were stained with Tilvestamab (anti-AXL) (Ab182880) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC₅₀=73.18 ng/mL.

Tilvestamab (anti-AXL) (Ab182880) - ELISA
Immobilized Human AXL Fc tag at 2.0 μg/mL can bind Tilvestamab (anti-AXL) (Ab182880) with the EC₅₀ of 3.40 ng/mL.

Tilvestamab (anti-AXL) (Ab182880) - Internalization
The endocytosis ratio Tilvestamab (anti-AXL) (Ab182880) by U251 cell increased with the increase of antibody concentration, and the Internalization Rate (%) reached 40% at antibody concentration of 1.0 nM.

Tilvestamab (anti-AXL) (Ab182880) - Phosphorylation
Tilvestamab (anti-AXL) (Ab182880) P-AKT Test was evaluated using U251 cell. The max induction fold was approximately 1.43.

Tilvestamab (anti-AXL) (Ab182880) - SEC
The purity of Tilvestamab (anti-AXL) (Ab182880) is more than 95% verified by HPLC.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
EGFR Tclin Epidermal growth factor receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AXL Tchem Tyrosine-protein kinase receptor UFO (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AXL Tchem Tyrosine-protein kinase receptor UFO (3469 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin MER intracellular domain/EGFR extracellular domain chimera (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AXL Tchem TEL/AXL (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Protein cereblon/Epidermal growth factor receptor (191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin EGFR/PPP1CA (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin VHL/EGFR (323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Baculoviral IAP repeat-containing protein 2/Epidermal growth factor receptor (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0404934Certificate of AnalysisFeb 24, 2026 Ab182880
ZJ24F0404935Certificate of AnalysisFeb 24, 2026 Ab182880
ZJ24F0404936Certificate of AnalysisFeb 24, 2026 Ab182880
Solution Calculators
Reviews

Customer Reviews

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View Animal Free grade guide → View Carrier Free grade guide → View Recombinant grade guide → View Validated grade guide → View ExactAb™ grade guide → View Low Endotoxin grade guide → View Azide Free grade guide →

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