Triisopropylsilane (TIPS) is an organosilicon compound that is low in toxicity, easy to handle, and capable of selectively reducing various functional groups, making it suitable as a reducing agent in organic synthesis. In the presence of Lewis acids (e.g., titanium tetrachloride), it can selectively reduce ketones and aldehydes to their corresponding alkanes, and epoxides to their corresponding alcohols.
Triisopropylsilane can be used as a reducing agent:
In the synthesis of 4-pyrrolobenzoyl peptides during solid-phase peptide synthesis.
In the reaction of amides with hydrosilanes catalyzed by transition metal complexes.
For the selective reduction of C-a
This compound belongs to the class of organic compounds known as hydrocarbon derivatives. These are derivatives of hydrocarbons obtained by substituting one or more carbon atoms by an heteroatom. They contain at least one carbon atom and heteroatom.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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