Triisopropylsilane(TIPS) - ≥98% , CAS No.6485-79-6

CAS: 6485-79-6 Cat. No.: T107280 Molecular Weight: 158.36 Beilstein Registry Number: 1733718 EC Number: 464-880-1

GRADE & PURITY ≥98%

Synonyms

EN300-117959 | J-525100 | tris(propan-2-yl)silane | PD118098 | AKOS006222744 | AS-19155 | Aksci Bulk ReagentTriisopropylsilane | Triisopropylsilane, 98% | A14931 | AKOS030228028 | Benzenesulfonic acid,5-[(4-amino-1-naphthalenyl)azo]-2-[2-[4-[(2-hydroxy-1-

Storage

Argon charged,Room temperature

Shipped In

Normal

Overview

Triisopropylsilane (TIPS) is an organosilicon compound that is low in toxicity, easy to handle, and capable of selectively reducing various functional groups, making it suitable as a reducing agent in organic synthesis. In the presence of Lewis acids (e.g., titanium tetrachloride), it can selectively reduce ketones and aldehydes to their corresponding alkanes, and epoxides to their corresponding alcohols.

Specifications

Synonyms

EN300-117959 | J-525100 | tris(propan-2-yl)silane | PD118098 | AKOS006222744 | AS-19155 | Aksci Bulk ReagentTriisopropylsilane | Triisopropylsilane, 98% | A14931 | AKOS030228028 | Benzenesulfonic acid, 5-[(4-amino-1-naphthalenyl)azo]-2-[2-[4-[(2-hydroxy-1-

Specifications & Purity

≥98%

Storage

Argon charged, Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504764056
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764056
• Canonical Smiles: CC(C)[Si](C(C)C)C(C)C
• InChIKey: ZGYICYBLPGRURT-UHFFFAOYSA-N
• INCHI: 1S/C9H21Si/c1-7(2)10(8(3)4)9(5)6/h7-9H,1-6H3
• Isomeric SMILES: CC(C)[Si](C(C)C)C(C)C
• WGK Germany: 3
• UN Number: 1993
• Molecular Weight: 158.36
• Beilstein: 1733718
• Reaxy-Rn: 1733718

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Hydrocarbon derivatives

• Kingdom: Organic compounds
• Superclass: Hydrocarbon derivatives
• Class: Not available
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydrocarbon derivatives
• Alternative Parents: Organosilicon compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Hydrocarbon derivative - Organosilicon compound - Organic metalloid moeity - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as hydrocarbon derivatives. These are derivatives of hydrocarbons obtained by substituting one or more carbon atoms by an heteroatom. They contain at least one carbon atom and heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Immiscible with water.
• Sensitivity: Moisture sensitive.
• Refractive Index: 1.434
• Flash Point(°F): 100.4 °F
• Flash Point(°C): 38 °C
• Boil Point(°C): 84-86 °C/35 mmHg (lit.)
• Molecular Weight: 157.350 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 3
• Exact Mass: 157.141 Da
• Monoisotopic Mass: 157.141 Da
• Topological Polar Surface Area: 0.000 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 65.700
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3

References

1. Gao-Feng Qi, Xin Cui, Xue-Feng Gong, Xu Cui, Huan-Ge Xu, Qi-Lin Liang, Kuo Zhang, Xiao-Ling Sha, Litao Li, Gui-Yuan Wang, Hong-Wen Liang, Lei Wang.  (2023)  A self-assembling peptide inhibits the growth and function of fungi via wrapping strategy.  Biomaterials Science,      [PMID:38193333] [10.1039/D3BM01845H]

2. Panpan Qi, Quankuo He, Junjie Zhang, Yuanyuan Lian, Ting Xie, Jianying Dong, Dongting Zhangsun, Yong Wu, Sulan Luo.  (2023)  Enhancing Stability and Albumin Binding Efficiency of α-Conotoxin GI through Fatty Acid Modification.  BIOCHEMISTRY,      [PMID:37967580] [10.1021/acs.biochem.3c00385]

3. Jiale Ma, Yiming Wu, Han Zou, Hongxun Wang, Min Zhou, Huajuan Wang.  (2023)  Acid-Responsive Aggregation of Gold Nanoparticles for the Photothermal Treatment of Bacterial Infections.  ACS Infectious Diseases,      [PMID:37963273] [10.1021/acsinfecdis.3c00389]

4. Jianchun Jiang, Qingmeng Pi, Jiahang Zhou, Yixuan Du, Yunbo Li.  (2023)  A simple preparation of ultrathin AuNWs-PEDOT:PSS bilayer Janus film for high performance chemiresistive ammonia gas sensor.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2023.134370]

5. Jiahang Zhou, Lingui Hu, Minqiang Xia, Yixuan Du, Yunbo Li.  (2023)  Nanometer-Thick Gold Nanowire Films with Spider-Web-Like Morphology as Transparent Conductors for Wearable Devices.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.3c02482]

6. Ruifang Li, Pu Hao, Kedong Yin, Qingpeng Xu, Shiming Ren, Yingyuan Zhao, Lan Zhang, Beibei Zhang.  (2023)  Activities of a broad-spectrum antimicrobial peptide analogue SAMP-A4-C8 and its combat against pneumonia in Staphylococcus aureus-infected mice.  JOURNAL OF PEPTIDE SCIENCE,  29  (11): (e3497).  [PMID:37088557] [10.1002/psc.3497]

7. Jing Li, Cailing Zhu, Wenjing Peng, Xiaoqing Cao, Hui Gao, Mengyuan Jiang, Zengqiang Wu, Chunmei Yu.  (2023)  Stretchable Electrochemical Sensor Based on a Gold Nanowire and Carbon Nanotube Network for Real-Time Tracking Cell-Released H2S.  ANALYTICAL CHEMISTRY,      [PMID:36669829] [10.1021/acs.analchem.2c04477]

8. Qing Hu, Yifei Wang, Lu Xu, Dawei Chen, Lifang Cheng.  (2023)  Transferrin Conjugated pH- and Redox-Responsive Poly(Amidoamine) Dendrimer Conjugate as an Efficient Drug Delivery Carrier for Cancer Therapy.  International Journal of Nanomedicine,      [PMID:32368053] [10.2147/IJN.S238536]

9. Liang Yan, Yongqi Ke, Yu Wang, Jingkui Yang, Yujian He, Li Wu.  (2022)  Effect of Mini-PEGs Modification on the Enzymatic Digestion of D-Amino Acid-Containing Peptides under the Action of PROK**.  CHEMISTRY-A EUROPEAN JOURNAL,  29  (16): (e202203524).  [PMID:36541269] [10.1002/chem.202203524]

10. Meng-Ru Ding, Qi-Lin Liang, Huan-Ge Xu, Xiang-Dan Li, Kuo Zhang, Zi-Jin Wei, Yong-Hong Gao, Qing-Shi Zhang, Rui Huang, Huai Yang, Lei Wang, Hao Wang.  (2022)  Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE against Allergic Rhinitis.  ACS Applied Materials & Interfaces,      [PMID:35749729] [10.1021/acsami.2c07092]

11. Xue-Li Liu, Yi-Fan Chen, Yi-Wen Chen, Wei-Kang Peng, Han-Chun Liu.  (2022)  Preparation of carbosilane quaternary ammonium surfactants and surface activity.  TENSIDE SURFACTANTS DETERGENTS,  59  (5): (424-432).  [PMID:] [10.1515/tsd-2022-2428]

12. Jianchun Jiang, Yongqing Zhang, Jiahang Zhou, Yizhou Jiang, Yunbo Li.  (2022)  Facile Surface Modification of Ultrathin Gold Nanowires Film with Hydrogen Sulfide for Improvement of Stability.  ADVANCED ENGINEERING MATERIALS,  24  (10): (2200509).  [PMID:] [10.1002/adem.202200509]

13. Xiao-Qin Yang, Li-Wen Bai, Yu Chen, Yue-Xiao Lin, Hua Xiang, Ting-Ting Xiang, Shuang-Xing Zhu, Li Zhou, Kai Li, Xinxiang Lei.  (2022)  Peptide probes with high affinity to target protein selection by phage display and characterization using biophysical approaches.  NEW JOURNAL OF CHEMISTRY,  46  (21): (10299-10307).  [PMID:] [10.1039/D2NJ00621A]

14. Zhiqi Zhao, Qiujin Li, Yu Dong, Jixian Gong, Zheng Li, Jianfei Zhang.  (2022)  Washable Patches with Gold Nanowires/Textiles in Wearable Sensors for Health Monitoring.  ACS Applied Materials & Interfaces,      [PMID:35427121] [10.1021/acsami.2c01729]

15. Yong-Hong Gao, Kuo Zhang, Meng-Ru Ding, Xue-Feng Gong, Hui Cao, Lei Wang.  (2022)  Hydrophobicity regulates self-assembly behavior of binding-induced fibrillogenesis peptides.  Colloid and Interface Science Communications,      [PMID:] [10.1016/j.colcom.2022.100622]

16. Ke Li, Ruxiang Li, Pengfei Zou, Li Li, Huajun Wang, Deqian Kong, Guangying Zheng, Li-Li Li.  (2022)  Glycopeptide-nanotransforrs eyedrops with enhanced permeability and retention for preventing fundus neovascularization.  BIOMATERIALS,      [PMID:34991034] [10.1016/j.biomaterials.2021.121361]

17. Zhiqi Zhao, Qiujin Li, Yu Dong, Jixian Gong, Zheng Li, Xiran Qiao, Jianfei Zhang.  (2021)  A Wearable Sensor Based on Gold Nanowires/Textile and Its Integrated Smart Glove for Motion Monitoring and Gesture Expression.  Energy Technology,  9  (7): (2100166).  [PMID:] [10.1002/ente.202100166]

18. Kuo Zhang, Hui Zhang, Xiao-Ran Zou, Ying Hu, Da-Yong Hou, Jia-Qi Fan, Chao Yang, Zi-Ming Chen, Shi-Fang Wen, Hui Cao, Pei-Pei Yang, Lei Wang.  (2021)  An antibody-like peptidic network for anti-angiogenesis.  BIOMATERIALS,      [PMID:34051670] [10.1016/j.biomaterials.2021.120900]

19. Liang Bao, Wenqiang Liu, Yonghua Chen, Yanbo Zhang, Yang Zhang.  (2021)  Enhanced blue emission from CsPb(Br/Cl)3 perovskite nanocrystals by localized surface plasmon resonance of Au nanoparticles.  Journal of Materials Chemistry C,  9  (15): (5182-5189).  [PMID:] [10.1039/D0TC05535B]

20. He Jiaqi, Chen Guoqin, Zhao Peng, Ou Caiwen.  (2021)  Near-infrared light-controllable bufalin delivery from a black phosphorus-hybrid supramolecular hydrogel for synergistic photothermal-chemo tumor therapy.  Nano Research,  14  (11): (3988-3998).  [PMID:] [10.1007/s12274-021-3325-z]

21. Gao Tingting, Xing Shu, Xu Mengjia, Fu Pan, Yao Jiechen, Zhang Xiaokang, Zhao Yang, Zhao Chao.  (2020)  A peptide nucleic acid–regulated fluorescence resonance energy transfer DNA assay based on the use of carbon dots and gold nanoparticles.  MICROCHIMICA ACTA,  187  (7): (1-10).  [PMID:32518969] [10.1007/s00604-020-04357-w]

22. Huajuan Wang, Jin Zhang, Zhiyong Song, Yongli Mu, Mohamed F. Foda, Yang Wu, Heyou Han.  (2020)  An intelligent platform based on acidity-triggered aggregation of gold nanoparticles for precise photothermal ablation of focal bacterial infection.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.127076]

23. Jianan Xu, Zhen Zhang, Shiyu Gan, Han Gao, Huijun Kong, Zhongqian Song, Xiaoming Ge, Yu Bao, Li Niu.  (2020)  Highly Stretchable Fiber-Based Potentiometric Ion Sensors for Multichannel Real-Time Analysis of Human Sweat.  ACS Sensors,      [PMID:32854495] [10.1021/acssensors.0c00960]

24. Xiao-Pei Li, Kai-Yun Qu, Feng Zhang, Han-Ning Jiang, Ning Zhang, Cheraga Nihad, Chao-Ming Liu, Kai-Hong Wu, Xiao-Wei Wang, Ning-Ping Huang.  (2020)  High-aspect-ratio water-dispersed gold nanowires incorporated within gelatin methacrylate hydrogels for constructing cardiac tissues in vitro.  Journal of Materials Chemistry B,  8  (32): (7213-7224).  [PMID:32638823] [10.1039/D0TB00768D]

25. Kuo Zhang, Pei-Pei Yang, Ping-Ping He, Shi-Fang Wen, Xiao-Ran Zou, Yu Fan, Zi-Ming Chen, Hui Cao, Zhou Yang, Kai Yue, Xinxin Zhang, Hua Zhang, Lei Wang, Hao Wang.  (2020)  Peptide-Based Nanoparticles Mimic Fibrillogenesis of Laminin in Tumor Vessels for Precise Embolization.  ACS Nano,      [PMID:32407069] [10.1021/acsnano.0c02110]

26. Ying Tang, Yang Chen, Liyuan Huang, Fan Gao, Hualing Sun, Cui Huang.  (2020)  Intramembranous Ossification Imitation Scaffold with the Function of Macrophage Polarization for Promoting Critical Bone Defect Repair.  ACS Applied Bio Materials,      [PMID:35025227] [10.1021/acsabm.0c00233]

27. Fan Jing Hao, Fan Gui Ling, Yuan Ping, Deng Fu An, Liu Ling Shan, Zhou Xiang, Yu Xi Yong, Cheng Hong, Li Shi Ying.  (2019)  A Theranostic Nanoprobe for Hypoxia Imaging and Photodynamic Tumor Therapy.  Frontiers in Chemistry,      [PMID:31921785] [10.3389/fchem.2019.00868]

28. Hong Cheng, Ping Yuan, Guiling Fan, Linping Zhao, Rongrong Zheng, Bin Yang, Xiaozhong Qiu, Xiyong Yu, Shiying Li, Xianzheng Zhang.  (2019)  Chimeric peptide nanorods for plasma membrane and nuclear targeted photosensitizer delivery and enhanced photodynamic therapy.  Applied Materials Today,      [PMID:] [10.1016/j.apmt.2019.04.017]

29. Ai-Nv Zhang, Wei Wu, Chi Zhang, Qiu-Yang Wang, Ze-Nan Zhuang, Han Cheng, Xian-Zheng Zhang.  (2019)  A versatile bacterial membrane-binding chimeric peptide with enhanced photodynamic antimicrobial activity.  Journal of Materials Chemistry B,  7  (7): (1087-1095).  [PMID:32254776] [10.1039/C8TB03094D]

30. Juang Wang, Zilong Zhou, Fang Zhang, Hui Xu, Wenli Chen, Tingting Jiang.  (2018)  A novel nanocomposite based on fluorescent turn-on gold nanostars for near-infrared photothermal therapy and self-theranostic caspase-3 imaging of glioblastoma tumor cell.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:29936383] [10.1016/j.colsurfb.2018.06.021]

31. Yuping Wei, Jiandong Xu, Liang Zhang, Yankai Fu, Xia Xu.  (2015)  Development of novel small peptide ligands for antibody purification.  RSC Advances,  5  (82): (67093-67101).  [PMID:] [10.1039/C5RA07829F]

32. Sen Lin, Fangfang Deng, Ping Huang, Lingli Li, Lei Wang, Qing Li, Ling Chen, Hao Chen, Kaihui Nan.  (2015)  A novel legumain protease-activated micelle cargo enhances anticancer activity and cellular internalization of doxorubicin.  Journal of Materials Chemistry B,  3  (29): (6001-6012).  [PMID:32262656] [10.1039/C5TB00736D]

33. Ting Liu, Fan Yang, Yongfeng Li, Liang Ren, Liqiang Zhang, Kai Xu, Xian Wang, Chunming Xu, Jinsen Gao.  (2013)  Plasma synthesis of carbon nanotube-gold nanohybrids: efficient catalysts for green oxidation of silanes in water.  Journal of Materials Chemistry A,  2  (1): (245-250).  [PMID:] [10.1039/C3TA13693K]

34. Yuxuan Wei, Zuxiao Chen, Chuyu Huang, Hong Cheng, Xiaofeng Jiang, Shiying Li.  (2024)  A breast cancer targeted photodynamic degrader to activate immunotherapy through EGFR degradation mediated PD-L1 downregulation.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.150822]

35. Liangxi Zhu, Zixiu Shen, Xiaoyang Liu, Runqun Tang, Ziyi Zhang, Furong Zhao, Jue Wang, Wenjun Zhan, Lei Zhou, Gaolin Liang, Rui Wang.  (2025)  Acid and phosphatase-triggered release and trapping of a prodrug on cancer cell enhance its chemotherapy.  BIOMATERIALS,      [PMID:40088578] [10.1016/j.biomaterials.2025.123254]

36. Zhuo-Ran Yang, Huimin Qin, Jing-Wen Fan, Kehan Du, Liya Qi, Dandan Hou, Hao Jiang, Jintao Zhu.  (2024)  Acidity-activated aggregation and accumulation of self-complementary zwitterionic peptide-decorated gold nanoparticles for photothermal biofilm eradication.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:38331692] [10.1016/j.jcis.2024.02.018]

37. Zhang Weiqi, Zeng Yinghua, Xiao Qiuqun, Wu Yuanyuan, Liu Jiale, Wang Haocheng, Luo Yuting, Zhan Jie, Liao Ning, Cai Yanbin.  (2024)  An in-situ peptide-antibody self-assembly to block CD47 and CD24 signaling enhances macrophage-mediated phagocytosis and anti-tumor immune responses.  Nature Communications,  15  (1): (1-19).  [PMID:38971872] [10.1038/s41467-024-49825-6]

38. Zi-Wen Qiu, Ying-Tao Zhong, Zhen-Ming Lu, Ni Yan, Ren-Jiang Kong, Jia-Qi Huang, Zhuo-Feng Li, Jun-Mei Nie, Runqing Li, Hong Cheng.  (2024)  Breaking Physical Barrier of Fibrotic Breast Cancer for Photodynamic Immunotherapy by Remodeling Tumor Extracellular Matrix and Reprogramming Cancer-Associated Fibroblasts.  ACS Nano,      [PMID:38507590] [10.1021/acsnano.4c01499]

39. Ying-Tao Zhong, Zi-Wen Qiu, Ke-Yan Zhang, Zhen-Ming Lu, Zhuo-Feng Li, Jun-Mei Nie, Yi Cen, Hong Cheng, Shi-Ying Li, Xiaoyuan Chen.  (2025)  Chemotherapeutics-enabled apoptosis-pyroptosis switch to trigger adaptive and innate immunity for metastatic breast cancer immunotherapy.  Materials Today,      [PMID:] [10.1016/j.mattod.2025.01.009]

40. Rongrong Zheng, Ni Yang, Qiuyuan Li, Zuxiao Chen, Chuyu Huang, Linping Zhao, Xin Chen, Shiying Li.  (2024)  Chimeric peptide-engineered immunostimulant for endoplasmic reticulum targeted photodynamic immunotherapy against metastatic tumor.  JOURNAL OF CONTROLLED RELEASE,      [PMID:39151829] [10.1016/j.jconrel.2024.08.013]

41. Peng Ye, Yuan Yang, Mengzhe Liu, Jiaqi Meng, Jingyang Zhao, Jiawei Zhao, Jinghui Wang, Qianyun Lu, Jing Liu, Luying Wang, Jiandu Lei, Changlong Wang.  (2025)  Co-Delivery of Morphologically Switchable Au Nanowire and Hemoglobin-Resveratrol Nanoparticles in the Microneedle for Diabetic Wound Healing Therapy.  ADVANCED MATERIALS,      [PMID:40066484] [10.1002/adma.202419430]

42. Fengwei Li, Mengmeng Zhang, Chao Liu, Jie Cheng, Yawen Yang, Xiangda Peng, Zhifeng Li, Wenfeng Cai, Haipeng Yu, Junjie Wu, Yuyu Guo, Hongkun Geng, Yun Fa, Youming Zhang, Dalei Wu, Yizhen Yin.  (2025)  De novo discovery of a molecular glue–like macrocyclic peptide that induces MCL1 homodimerization.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,  122  (13): (e2426006122).  [PMID:40131955] [10.1073/pnas.2426006122]

43. Chaofan Nie, Tao Feng, Peiren Wang, Xueqing Jiang, Pandi Peng, Xue Yang, Junru Wang, Luofeng Yu, Yuxin Guo, Peng Li.  (2024)  Dual metabolic modification of tumor-targeted bacteria for synergistic chemo-photodynamic therapy and immunotherapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.154567]

44. Jiayi Bian, Yingjie Xu, Minghao Sun, Zerui Ma, Hao Li, Changrui Sun, Fei Xiong, Xiaopeng Zhao, Wenjing Yao, Yue Chen, Yuanyuan Ma, Xikuang Yao, Shenghong Ju, Wenpei Fan.  (2024)  Engineering AIEgens-Tethered Gold Nanoparticles with Enzymatic Dual Self-Assembly for Amplified Cancer-Specific Phototheranostics.  ACS Nano,      [PMID:39300974] [10.1021/acsnano.4c07403]

45. Yulu Ye, Jiahang Zhou, Minqiang Xia, Yunbo Li.  (2025)  Fabrication of Highly Efficient Nanogold Membrane Catalysts Utilizing Ultrathin Gold Nanowires in the Presence of Thiourea.  Journal of Physical Chemistry C,      [PMID:] [10.1021/acs.jpcc.4c07999]

46. Ke Ma, Meng Yin, Xiao-Xue Wang, Chen-Yu Wang, Ke-Zheng Chen, Sheng-Lin Qiao.  (2024)  Gold Nanocluster-Based Nanozyme for High-Throughput Colorimetric Detection of SARS-CoV-2.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.4c01049]

47. Jiahang Zhou, Minqiang Xia, Lingui Hu, Yunbo Li.  (2024)  In Situ Growth of Gold Nanofilms with Branched Structures in the Presence of Organosulfur for High-Performance Flexible Electronics.  LANGMUIR,      [PMID:39155670] [10.1021/acs.langmuir.4c01993]

48. Zhou Laicheng, Zhu Longchen, Wang Cong, Xu Tengyan, Wang Jing, Zhang Bin, Zhang Xin, Wang Huaimin.  (2025)  Multiphasic condensates formed with mono-component of tetrapeptides via phase separation.  Nature Communications,  16  (1): (1-14).  [PMID:40108179] [10.1038/s41467-025-58060-6]

49. Yeyang Wu, Yanmei Li, Ni Yan, Jiaqi Huang, Xinyu Li, Keyan Zhang, Zhenming Lu, Ziwen Qiu, Hong Cheng.  (2024)  Nuclear-targeted chimeric peptide nanorods to amplify innate anti-tumor immunity through localized DNA damage and STING activation.  JOURNAL OF CONTROLLED RELEASE,      [PMID:38580138] [10.1016/j.jconrel.2024.04.008]

50. Zhen-Ming Lu, Zi-Wen Qiu, Yan-Mei Li, Ke-Yan Zhang, Ye-Yang Wu, Ni Yan, Hong Cheng.  (2025)  PD-L1-Targeting Autophagy Modulator to Upregulate MHC-I and Activate Photo-Immunotherapy for Metastatic Tumor Eradication.  ACS Applied Materials & Interfaces,      [PMID:40132080] [10.1021/acsami.5c00029]

51. Ying-Tao Zhong, Zi-Wen Qiu, Ke-Yan Zhang, Zhen-Ming Lu, Zhuo-Feng Li, Yi Cen, Shi-Ying Li, Hong Cheng.  (2025)  Plasma Membrane Targeted Photodynamic Nanoagonist to Potentiate Immune Checkpoint Blockade Therapy by Initiating Tumor Cell Pyroptosis and Depleting Infiltrating B Cells.  ADVANCED MATERIALS,      [PMID:40012447] [10.1002/adma.202415078]

52. Kang Yang, Di Liu, Lei Feng, Liugen Xu, Yangang Jiang, Xiran Shen, Amjad Ali, Jianwei Lu, Li Guo.  (2024)  Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship.  Polymers,  16  (7): (990).  [PMID:38611248] [10.3390/polym16070990]

53. Jiamin Wang, Hao Lin, Mengli Liu, Bo Xiong, Dingyuan He, Jiasheng Tu, Dongsheng He.  (2024)  Tuning charge density and crosslinking of precise amphiphilic oligo(ethanamino)amides for efficient and biocompatible gene delivery.  NEW JOURNAL OF CHEMISTRY,      [PMID:] [10.1039/D3NJ05077G]

54. Wei Cheng, Jiaojiao Yang, Yuqing Pan, Haijing Qu, Zhiran Duan, Jie Wu, Han Chen, Chao Wang, Xiangdong Xue.  (2025)  Noninvasive Activation of Local and Systemic Immunity with a Sequential-Targeting Sonodynamic Nanovaccine to Treat Glioblastoma.  ACS Nano,      [PMID:40698543] [10.1021/acsnano.5c08928]

55. Haizhu Shi, Qian Chen, Shuling Yang, Chungu Zhang, Yu Wan, Shun Feng, Lian-Hai Shan.  (2025)  Biomimetic Epitope-Imprinted Nanogatekeepers on Mesoporous Silica for Tumor-Targeted Drug Delivery.  ACS Applied Bio Materials,      [PMID:40792690] [10.1021/acsabm.5c01295]

56. Lin Yi, Li Mengyao, Luo Zijin, Meng Yanan, Zong Yan, Ren Hongyu, Yu Xiaolu, Tan Xiaoqiong, Liu Fan, Wei Tuo, Cheng Qiang.  (2025)  Tissue-specific mRNA delivery and prime editing with peptide–ionizable lipid nanoparticles.  NATURE MATERIALS,      [PMID:40890498] [10.1038/s41563-025-02320-9]

57. Hua Cai, Rongrong Zheng, Ningxia Wu, Jiaman Hu, Ruixin Wang, Jianing Chi, Wei Zhang, Linping Zhao, Hong Cheng, Ali Chen, Shiying Li, Lin Xu.  (2023)  Chimeric Peptide Engineered Nanomedicine for Synergistic Suppression of Tumor Growth and Therapy-Induced Hyperlipidemia by mTOR and PCSK9 Inhibition.  Pharmaceutics,  15  (10): (2377).  [PMID:37896137] [10.3390/pharmaceutics15102377]

58. Tiantian Wei, Jingjing Wu, Xiran Shen, Zhifeng Qiu, Li Guo.  (2021)  Self-Assembled Membrane-like Nanomaterials from Sequence-Defined Peptoid Block Copolymers.  Polymers,  13  (15): (2389).  [PMID:34371992] [10.3390/polym13152389]

59. Hua Weiwen, Wang Yuanguang, Guo Cun-Yue, Wang Jianjun, Li Songjun, Guo Li.  (2020)  Ice Recrystallization Inhibition Activity of Protein Mimetic Peptoids.  Journal of Inorganic and Organometallic Polymers and Materials,  31  (1): (203-208).  [PMID:] [10.1007/s10904-020-01673-9]

60. Yinghao Ding, Xueying Zhu, Jian Wen, Junchao Xiong, Shengyi Zhang, Zhimou Yang, Zhi-Wen Hu.  (2025)  Tumor-Targeting Co-Delivery of T-Cell Antigen and Camptothecin Guided by Cascade-Responsive Peptide Self-Assembly to Reshape Tumor Antigenicity for Cancer Immunotherapy.  ADVANCED MATERIALS,      [PMID:41217090] [10.1002/adma.202516767]

61. Hong Cheng, Jing-Hao Fan, Lin-Ping Zhao, Gui-Ling Fan, Rong-Rong Zheng, Xiao-Zhong Qiu, Xi-Yong Yu, Shi-Ying Li, Xian-Zheng Zhang.  (2019)  Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy.  BIOMATERIALS,      [PMID:31078049] [10.1016/j.biomaterials.2019.05.004]

62. Jing Zhang, Biao Shen, Liqun Chen, Lingdong Chen, Yangsheng Meng, Jie Feng.  (2018)  A dual-sensitive mesoporous silica nanoparticle based drug carrier for cancer synergetic therapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:30522009] [10.1016/j.colsurfb.2018.11.071]

63. Hong Cheng, Gui-Ling Fan, Jing-Hao Fan, Ping Yuan, Fu-An Deng, Xiao-Zhong Qiu, Xi-Yong Yu, Shi-Ying Li.  (2019)  Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy.  BIOMATERIALS,      [PMID:31541935] [10.1016/j.biomaterials.2019.119497]

64. Sangshuang Li, Huayang Liu, Yu Fang, Yaoting Li, Laicheng Zhou, Dinghao Chen, Juan Liang, Huaimin Wang.  (2025)  Programming Two-component Peptides Self-assembly by Tuning the Hydrophobic Linker.  FARADAY DISCUSSIONS,      [PMID:40366063] [10.1039/D4FD00209A]

65. Shicheng Pei, Zhaohan Liu, Qishu Jiao, Qiling Jin, Xuan Luo, Yuanyuan Liu, Shuyao Zhou, Shuqin Pang, Xiaoxing Wu, Keming Xu, Wenying Zhong.  (2025)  Self-Reporting Ratiometric AIEgen-Peptide Nanoprobes for Activatable Chemotherapy and Noninvasive Imaging of Therapeutic Outcomes.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:40170557] [10.1021/acs.jmedchem.5c00372]

66. Haizhu Shi, Mengzhao Wen, Weige Dong, Chungu Zhang, Lian-Hai Shan, Ming-Yu Wu, Shun Feng.  (2025)  Orchestrated Molecularly Imprinted Nanoparticles for Tumor-Targeted and Chemo-Photothermal Therapy.  ACS Applied Materials & Interfaces,      [PMID:40327823] [10.1021/acsami.5c01212]

67. Jia-li Liu, Xin-xin Song, Xiao-Rong Li, Ping Chen, Zhipeng Cheng, Hui Zhong, Haiyan Qian.  (2025)  Gold-platinum bimetallic nanowires on graphene oxide nanosheets for oxygen reduction reaction.  NEW JOURNAL OF CHEMISTRY,      [PMID:] [10.1039/D5NJ00652J]

68. Lei Feng, Liugen Xu, Junhao Wen, Minghai Zhao, Amjad Ali, Naushad Ahmad, Jianwei Lu, Li Guo.  (2025)  Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids.  Biomimetics,  10  (6): (368).  [PMID:40558337] [10.3390/biomimetics10060368]

69. Fawei He, Yunfei Cui, Xue Tang, Dongting Zhangsun, Sulan Luo, Yong Wu.  (2025)  Synthesis of the plant cyclotide cyO14 via the hydrazide strategy and investigation of its antibacterial and insecticidal activities.  PEPTIDES,      [PMID:40543849] [10.1016/j.peptides.2025.171423]

70. Shiqi Li, Chao Sun, Meihui Gao, Haiyan Ma, Longbin Xu, Xinyu Li.  (2025)  Development and Electrochemical Performance of a PANI-PA-PVA Hydrogel-Based Flexible pH Fiber Sensor for Real-Time Sweat Monitoring.  Gels,  11  (11): (853).  [PMID:41294538] [10.3390/gels11110853]

71. Weiqi Zhang, Linjia Chen, Yahui Dong, Yinghua Zeng, Yongyu Chen, Yue Liu, Jingru Wang, Fujun Shi.  (2026)  In situ delivery of JPH203 via camptothecin-peptide conjugate nanoassemblies to trigger ferroptosis in triple-negative breast cancer.  JOURNAL OF CONTROLLED RELEASE,      [PMID:] [10.1016/j.jconrel.2026.114829]

72. Jiaxin Zhou, Juan Liu, Xilin Liu, Lixia Ren, Zhilin Yu, Zhen Zheng, Gongyu Li.  (2026)  Clinically relevant stereochemistry reprograms amyloid proteome for aggregation cross-talk–conferred neuroprotection.  Science Advances,  12  (13):   [PMID:] [10.1126/sciadv.aeb2729]