Infliximab (anti-TNF-alpha) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to TNFSF2/TNFa, >95%, Human IgG1, INHIBITOR of TNF-alpha inhibitor, INHIBITOR of TNF-alpha inhibitor

CAS: 170277-31-3 Cat. No.: I412009

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human

Isotype

Human IgG1

Conjugation

Unconjugated

Overview

Infliximab (anti-TNF-alpha) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α, prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2), has the potential for treatment of Crohn's disease and rheumatoid arthritis.  

Specifications

Product Name

Infliximab (anti-TNF-alpha) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to TNFSF2/TNFa, >95%, Human IgG1, INHIBITOR of TNF-alpha inhibitor

Synonyms

Infliximab | Remicade | Remsima | Inflectra | Avakine | CT-P13 | APC1 antibody | APC1 protein antibody | Cachectin antibody | DIF antibody | Differentiation inducing factor antibody | Macrophage cytotoxic factor antibody | Tnf antibody | TNF superfamily m

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Biochemical and Physiological Mechanisms

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is i

Host species

Human

Specificity

TNFSF2/TNFa

Application

ELISA, Functional Assay, Flow cytometry, Kinetics (BLI), Kinetics (SPR)

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

INHIBITOR

Mechanism of action

INHIBITOR of TNF-alpha inhibitor

Antibody Type

Primary antibody

Clonality

Recombinant

Isotype

Human IgG1

Light Chain Type

kappa

SDS-PAGE

27.6 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 186.7 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Source

CHO supernatant

Concentration

See COA

CAS

170277-31-3

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

ELISA: Infliximab (anti-TNF-alpha) (I412009)

Infliximab (anti-TNF-alpha) (I412009) - ELISA
Immobilized Recombinant Human TNF-α protein (rp156007) at 1.0 μg/mL can bind Infliximab (anti-TNF-alpha) (I412009) with the EC50 of 22.22 ng/mL.

ELISA: Infliximab (anti-TNF-alpha) (I412009)

Infliximab (anti-TNF-alpha) (I412009) - ELISA
Immobilized Recombinant huTNF-alpha- ECD-His protein at 2.0 μg/mL can bind Infliximab (anti-TNF-alpha) (I412009) with the EC50 of 26.34 ng/mL.

SEC: Infliximab (anti-TNF-alpha) (I412009)

Infliximab (anti-TNF-alpha) (I412009) - SEC
The purity of Infliximab (anti-TNF-alpha) (I412009) is more than 95% verified by HPLC.

Associated Targets(Human)

TNF Tclin Tumor necrosis factor (0 Activities)

Discover Target: TNF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action