Nimodipine - Moligand™, ≥98% , Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4, CAS No.66085-59-4, Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4

CAS: 66085-59-4 Cat. No.: N129506 Molecular Weight: 418.44 EC Number: 266-127-0
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
Nimodipine ap | SPECTRUM1503600 | 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester | DTXCID0033
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
250mg
N129506-250mg
3
$9.90
1g
N129506-1g
3
$14.90
5g
N129506-5g
1
$29.90
25g
N129506-25g
3
$93.90
100g
N129506-100g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$229.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 13 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders.

Specifications

Synonyms
Nimodipine ap | SPECTRUM1503600 | 2-methoxyethyl propan-2-yl 2, 6-dimethyl-4-(3-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate | 3, 5-Pyridinedicarboxylic acid, 1, 4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester | DTXCID0033
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.L-type Ca 2+ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine.
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ACTIVATOR, ALLOSTERIC MODULATOR, ANTAGONIST, GATING INHIBITOR
Mechanism of action
Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%
Names and Identifiers
Pubchem Sid504750774
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750774
Canonical SmilesCC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
IUPAC Name3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKeyUIAGMCDKSXEBJQ-UHFFFAOYSA-N
INCHI1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
Isomeric SMILES CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
WGK Germany 1
RTECS US7975500
Molecular Weight 418.44
Reaxy-Rn 459792
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=459792&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassPyridines and derivatives
SubclassHydropyridines
Intermediate Tree Nodes Dihydropyridines
Direct ParentDihydropyridinecarboxylic acids and derivatives
Alternative Parents Nitrobenzenes  Nitroaromatic compounds  Dicarboxylic acids and derivatives  Vinylogous amides  Enoate esters  Amino acids and derivatives  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Dialkyl ethers  Dialkylamines  Enamines  Organic oxoazanium compounds  Carbonyl compounds  Organic zwitterions  Hydrocarbon derivatives  Organopnictogen compounds  Organic oxides  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Dihydropyridinecarboxylic acid derivative - Nitrobenzene - Nitroaromatic compound - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Benzenoid - Vinylogous amide - Enoate ester - Alpha,beta-unsaturated carboxylic ester - Amino acid or derivatives - Carboxylic acid ester - C-nitro compound - Organic nitro compound - Carboxylic acid derivative - Dialkyl ether - Secondary aliphatic amine - Enamine - Ether - Azacycle - Organic 1,3-dipolar compound - Organic oxoazanium - Secondary amine - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organic oxygen compound - Carbonyl group - Amine - Organopnictogen compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic zwitterion - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. These are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
External Descriptors C-nitro compound - diester - dihydropyridine
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CYP2C19 Tchem Cytochrome P450 2C19 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CFTR Tclin Cystic fibrosis transmembrane conductance regulator (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C2 Tclin Mineralocorticoid receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1F Tchem Voltage-dependent L-type calcium channel subunit alpha-1F (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1S Tclin Voltage-dependent L-type calcium channel subunit alpha-1S (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
P2RX4 Tchem P2X purinoceptor 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 (11476 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
F2612264Certificate of AnalysisJun 01, 2026 N129506
F2612268Certificate of AnalysisJun 01, 2026 N129506
F2625559Certificate of AnalysisJun 01, 2026 N129506
F2625560Certificate of AnalysisJun 01, 2026 N129506
F2625566Certificate of AnalysisJun 01, 2026 N129506
F2221291Certificate of AnalysisJan 20, 2026 N129506
F2221407Certificate of AnalysisJan 20, 2026 N129506
L2413670Certificate of AnalysisMar 27, 2024 N129506
L2413671Certificate of AnalysisMar 27, 2024 N129506
L2413672Certificate of AnalysisMar 27, 2024 N129506
G1524098Certificate of AnalysisFeb 06, 2023 N129506
F2118342Certificate of AnalysisJun 21, 2021 N129506

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Chemical and Physical Properties
SolubilitySoluble in methanol (62.5 mg/ml), DMSO (25 mg/ml), dioxane, water (24.3 mg/L) at 25 °C, and ethanol (10 mM). Insoluble in 2-hydroxypropyl-b-cyclodextrin.
Melt Point(°C)125°C
Molecular Weight418.400 g/mol
XLogP33.100
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass418.174 Da
Monoisotopic Mass418.174 Da
Topological Polar Surface Area120.000 Ų
Heavy Atom Count30
Formal Charge0
Complexity736.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Ting Ma, Geng Ou.  (2023)  Fabrication of a highly sensitive electrochemical sensor for the rapid detection of nimodipine.  International Journal of Electrochemical Science,      [PMID:] [10.1016/j.ijoes.2023.01.018]
2. Qiyao Wang, Difan Zhang, Jiani Lu, Jiaying Zhang, Zhenquan Xuan, Luyun Gong, Mengxiang Yang, Lingli Jin, Jingyang Le, An Zhu, Hongze Liang, C. Benjamin Naman, Jinrong Zhang, Li Zhao, Shan He, Qinwen Wang, Hao Liu, Xiaojun Yan, Lingling Zhao, Wei Cui.  (2022)  PLGA-PEG-fucoxanthin nanoparticles protect against ischemic stroke in vivo.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2022.105359]
3. Zhu-Jun Zhong, Zhong-Ping Yao, Zi-Qi Shi, Yang-Dan Liu, Li-Fang Liu, Gui-Zhong Xin.  (2021)  Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach.  ANALYTICAL CHEMISTRY,      [PMID:34107211] [10.1021/acs.analchem.1c01259]
4. Liu Wei, Wang Ruya, Hu Fan, Wu Pinping, Huang Tao, Fizir Meriem, He Hua.  (2018)  Novel mixed hemimicelles based on nonionic surfactant–imidazolium ionic liquid and magnetic halloysite nanotubes as efficient approach for analytical determination.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  410  (28): (7357-7371).  [PMID:30294762] [10.1007/s00216-018-1348-4]
5. Nani Wang, Qiaoyan Zhang, Hailiang Xin, Dan Shou, Luping Qin.  (2017)  Osteoblast cell membrane chromatography coupled with liquid chromatography and time-of-flight mass spectrometry for screening specific active components from traditional Chinese medicines.  JOURNAL OF SEPARATION SCIENCE,  40  (22): (4311-4319).  [PMID:28884956] [10.1002/jssc.201700688]
6. Jiale Liu, Kai Liu, Xinyuan Cui, Yujie Ji, Zhaoqi Ding, Zenghui Chang, Junshuo Zhang, Xinyi Wang, Yuanyuan Liu.  (2025)  From gut to brain: donepezil and nimodipine combination therapy improves cognitive deficits in Alzheimer's disease via gut microbiota and metabolites.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:40737743] [10.1016/j.bbrc.2025.152418]
7. Bowen Li, Wentao Yu, Lan Yang.  (2023)  Osmundacetone Alleviates Cerebral Ischemia–Reperfusion Injury in Rats.  BIOLOGICAL & PHARMACEUTICAL BULLETIN,  46  (11): (1527-1534).  [PMID:37673653] [10.1248/bpb.b23-00326]
8. Xingfang Zhang, Liang Gao, Jianv Wang, Wei Zhang, Dong Xu, Yanhua Wang, Tianlong Liu, Kai Gao, Zhen Ren, Yi Ding.  (2025)  Study of the ameliorative effect of β-Bisabolene on ischemic stroke via COX-2 with the Keap1/Nrf2 and MAPK pathways.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:40441590] [10.1016/j.ejphar.2025.177773]
9. Lang Liu, Jingyu Weng, Lei Yue, Yuanyuan Qin, Jia Yu, Yaqi Li, Shuming Li, Jiaofeng Wu, Yuangui Yang, Zhishu Tang, Hongbo Xu.  (2025)  Rosmarinic acid suppresses ferroptosis and confers neuroprotection in cerebral ischemia-reperfusion via direct KEAP1 inhibition and NRF2 activation.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:41167534] [10.1016/j.freeradbiomed.2025.10.291]
10. Lin Tang, Ao Wang, Hecheng Wu, Wenkai Liu, Feng Luo, Jiehua Li, Zhen Li, Hong Tan.  (2025)  Microphase Structure and Component Influence on Drug Sorption: Polyurethane-Drug Interaction Elucidation in Medical Catheter Systems.  ACS Applied Materials & Interfaces,      [PMID:41261068] [10.1021/acsami.5c15217]
11. Xiaofeng Wang, Jue Wang, Xia Zhao, Langui Xie, Rui Yang, Chunmeng Sun, Jiasheng Tu, Huimin Sun.  (2025)  Drug-Dependent Enhancement of Blood–Brain Barrier Permeation by Polysorbate 80 Minor Components.  Pharmaceutics,  17  (12): (1572).  [PMID:41471087] [10.3390/pharmaceutics17121572]
12. Li Anan, Lu Shijie, Shang Xueqing, Zhang He, Xie Min, Lu Qiao, Hu Yongjun.  (2026)  Visualizing xenobiotics and metabolites in zebrafish by VUV-laser desorption post-ionization mass spectrometry imaging.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:41586896] [10.1007/s00216-026-06344-1]
13. Pongsigeraxi Borjigin, Caixia Deng, Rilaga Su, Juan Li, Ying Ying, Yingsong Chen, Tegexibaiyin Wang.  (2026)  Pearl Powder Fluorescent Carbon Dots Alleviate Neuroinflammation in Cerebral Ischemia/Reperfusion Through Suppression of Anxa2/NF-κB Signaling Pathway.  International Journal of Nanomedicine,      [PMID:] [10.2147/IJN.S567974]
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