Feladilimab (anti-ICOS) - Primary antibody, specific to ICOS, >95%, Human IgG4PE, AGONIST of Inducible T-cell costimulator agonist, AGONIST of Inducible T-cell costimulator agonist

CAS: 2252518-85-5 Cat. No.: Ab176561

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human

Isotype

Human IgG4PE

Conjugation

Unconjugated

Overview

Feladilimab (anti-ICOS) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab (anti-ICOS) binds to ICOS-expressing T cells. Feladilimab (anti-ICOS) has the potential for the research of cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Feladilimab (anti-ICOS) - Primary antibody, specific to ICOS, >95%, Human IgG4PE, AGONIST of Inducible T-cell costimulator agonist

Synonyms

Activation-inducible lymphocyte immunomediatory molecule

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

ICOS

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

AGONIST

Mechanism of action

AGONIST of Inducible T-cell costimulator agonist

Isotype

Human IgG4PE

Light Chain Type

kappa

SDS-PAGE

27.0 kDa (Light Chain) & 53.2 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Concentration

See COA

CAS

2252518-85-5

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Flow Cytometry: Feladilimab (anti-ICOS) (Ab176561)

Feladilimab (anti-ICOS) (Ab176561) - Flow Cytometry
Flow Cytometry analysis of 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated Jurkat cells (24h) labelling ICOS (red) with Feladilimab (anti-ICOS) (Ab176561). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Feladilimab (anti-ICOS) (Ab176561)

Feladilimab (anti-ICOS) (Ab176561) - SEC
The purity of Feladilimab (anti-ICOS) (Ab176561) is more than 95% verified by HPLC.

ELISA: Feladilimab (anti-ICOS) (Ab176561)

Feladilimab (anti-ICOS) (Ab176561) - ELISA
Immobilized hu-ICOS ECD-21-140-Fc at 2.0 μg/mL can bind Feladilimab (anti-ICOS) (Ab176561) with the EC₅₀ of 33.30 ng/mL.

Associated Targets(Human)

ICOS Tbio Inducible T-cell costimulator (0 Activities)

Discover Target: ICOS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action